anti-Lysosomal Trafficking Regulator (LYST) Antibodies

LYST encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Additionally we are shipping LYST Kits (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LYST 1130 Q99698
Anti-Mouse LYST LYST 17101 P97412
Anti-Rat LYST LYST 85419  
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Top anti-LYST Antibodies at

Showing 4 out of 6 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged LYST is 0.03 ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
Human Mouse Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ICC, IF Immunocytochemistry/Immunofluorescence: LYST Antibody  - Staining of human cell line HEK 293 shows localization to nucleoplasm & microtubule organizing center. 100 μL Log in to see 10 to 13 Days
Human Mouse Un-conjugated ELISA (Capture), ELISA   100 μg Log in to see 6 to 8 Days

LYST Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,

Top referenced anti-LYST Antibodies

  1. Human Monoclonal LYST Primary Antibody for ELISA - ABIN514402 : Sánchez-Guiu, Antón, García-Barberá, Navarro-Fernández, Martínez, Fuster, Couselo, Ortuño, Vicente, Rivera, Lozano: Chediak-Higashi syndrome: description of two novel homozygous missense mutations causing divergent clinical phenotype. in European journal of haematology 2013 (PubMed)

More Antibodies against LYST Interaction Partners

Human Lysosomal Trafficking Regulator (LYST) interaction partners

  1. homozygous c.6077_6078insA (p.Tyr2026Terfs) mutation was detected in the LYST gene in both patients

  2. LYST mutations in sporadic chordoma

  3. Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (cg16962115, FDR = 1.24E-04), CADM1 (show CADM1 Antibodies) (cg21933078, FDR = 1.22E-02) and NFATC1 (show NFATC1 Antibodies) (cg06784563, FDR = 1.46E-02)

  4. Mutation in LYST gene is associated with hemophagocytic lymphohistiocytosis.

  5. Effects of LYST mutations in Chediak-Higashi syndrome show that LYST is involved in regulation of natural killer cell lytic activity, from lytic granule size to polarization and exocytosis, as well as endolysosomal compartment identity.

  6. Lack of LYST during endolysosomal biogenesis leads to the formation of enlarged hybrid organelles and blocks the terminal maturation of lytic granules into secretory granules.

  7. Lysosome degradation and traffcking of cargo via autophagy, endocytosis or retrograde transport are not affected by LYST depletion.

  8. involved in the regulation of phospholipase D (show PLD Antibodies) activity

  9. present an AR-HSP family with cerebellar ataxia and neuropathy with a novel homozygous missense mutation in the lysosomal trafficking regulator (LYST) gene. LYST is known as the causative gene for Chediak-Higashi syndrome.

  10. this is the first report of a severe early-onset Chediak-Higashi syndrome (CHS0 with a homozygous LYST/CHS1 missense mutation.

Mouse (Murine) Lysosomal Trafficking Regulator (LYST) interaction partners

  1. Lyst as a specific regulator of TLR3 (show TLR3 Antibodies)- and TLR4 (show TLR4 Antibodies)-mediated TRIF (show RNF138 Antibodies) signaling pathways reveals how the regulation of the intracellular membrane trafficking network is functionally linked to specific TLR signaling pathways.

  2. results identify an association between oxidative damage to lipid membranes and the severity of Lyst-mutant phenotypes, revealing a new mechanism that contributes to pathophysiology involving LYST

  3. the Lyst(Ing3618 )allele could represent a new model for adult Chediak-Higashi syndrome with neurological impairment

  4. Apolipoprotein E (ApoE (show APOE Antibodies))-deficient beige mice have markedly reduced development of atherosclerotic lesions when fed a chow diet; expression of the beige mutation in all cell types involved in lesion development contributes to atheroprotection.

  5. The upregulation of LYST/Beige in infected cells functions as a host innate response to limit parasite growth.

  6. These results demonstrated that mutation of the Lyst gene can produce ocular features of human XFS (show FST Antibodies) (exfoliation syndrome) and suggested that LYST or LYST-interacting genes may contribute to XFS (show FST Antibodies).

LYST Antigen Profile

Protein Summary

This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with LYST

  • lysosomal trafficking regulator (LYST) antibody
  • lysosomal trafficking regulator (lyst) antibody
  • lysosomal trafficking regulator (AaeL_AAEL005066) antibody
  • lysosomal trafficking regulator (CpipJ_CPIJ005368) antibody
  • lysosomal trafficking regulator (Lyst) antibody
  • Beige antibody
  • bg antibody
  • CHS antibody
  • CHS1 antibody
  • D13Sfk13 antibody

Protein level used designations for LYST

lysosomal trafficking regulator , lysosomal-trafficking regulator-like , Chediak-Higashi syndrome 1 , beige homolog , lysosomal-trafficking regulator , CHS1 homolog

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1130 Homo sapiens
17101 Mus musculus
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