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LOXL1 encodes a member of the lysyl oxidase gene family. Additionally we are shipping LOXL1 Antibodies (81) and LOXL1 Proteins (16) and many more products for this protein.
Showing 3 out of 19 products:
Human LOXL1 ELISA Kit for Sandwich ELISA - ABIN421169
Coral, Madhavan, Pukhraj, Angayarkanni: High glucose induced differential expression of lysyl oxidase and its isoform in ARPE-19 cells. in Current eye research 2013
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high lysyl oxidase (show LOX ELISA Kits) activity is associated with ischemic hearts.
the rs11638944:C>G transversion exerts a cis-acting effect on the expression levels of LOXL1, mediated by differential binding of the transcription factor retinoid X receptor alpha (show RXRA ELISA Kits) and by modulating alternative splicing of LOXL1, eventually leading to reduced levels of LOXL1 mRNA in cells and tissues of risk allele carriers for pseudoexfoliation syndrome
LOXL1/LOXL2 (show LOXL2 ELISA Kits) gene expression and protein levels were increased in Idiopathic pulmonary fibrosis (IPF) versus non-IPF.
This study focused on the relationship between lysyl oxidase (LOX (show LOX ELISA Kits)), LOX (show LOX ELISA Kits)-like protein 1 (LOXL1), and LOXL2 (show LOXL2 ELISA Kits) and pulmonary emphysema pathogenesis.
These findings provide evidence for a functional role of alternative splicing coupled to NMD in the posttranscriptional regulation of LOXL1 gene expression and suggest this mechanism to represent a dynamic mode of adapting LOXL1 expression to PEX (show PHEX ELISA Kits)-associated environmental and nutritional cues.
remenopausal and postmenopausal women with Pelvic Organ Prolapse (POP (show PREP ELISA Kits)) exhibit differential expression of LOXL1 suggesting different pathways in the pathogenesis of POP (show PREP ELISA Kits). The role of biopsy location on LOXL1 expression requires further investigation.
In this study, we found no significant association between allele and genotype frequencies of APOE (show APOE ELISA Kits); the intronic SNP rs2165241 and the non-synonymous SNP rs3825942 in exon 1 of LOXL1 are significantly associated with pseudoexfoliation syndrome and exfoliation glaucoma in the Turkish population.
The LOXL1 SNPs, rs1048661 and rs3825942, are associated with PXF in the South Indian population correlating with lowered LOX (show LOX ELISA Kits) activity in the aqueous humor. The increased level of total TGF-beta (show TGFB1 ELISA Kits) in the aqueous humor of PXF cases is possibly associated with LOX (show LOX ELISA Kits) regulation which needs further investigation.
A rare protective allele at LOXL1,Tyr407Phe, was identified. It is found exclusively in the Japanese population. It confers 25-fold resistance to XFS (show FST ELISA Kits). It segregated with the common rs3825942[A] (p.Asp153) in all but 2 patients examined. In spheroids, this haplotype conferred a significant increase in the strength of cellular adhesion in comparison to 3 haplotypes with the wild-type allele.
Findings of this current study indicate a different LOXL1 gene expression pattern compared with a recent study that was also performed in the Turkish population.
LOXL1 transcriptional activity was dramatically reduced when a recombinant DNMT3A (show DNMT3A ELISA Kits) was concomitantly overexpressed.
findings strongly suggested that elastin (show ELN ELISA Kits) crosslinking and LOXL1 were co-associated with liver cirrhosis, while selective inhibition of LOXL1 arrested disease progression by reducing crosslinking of elastin (show ELN ELISA Kits).
LOXL1-/- mutant mice develop appendicular and axial skeletal phenotypes characterized by decreased bone volume fraction and compromised trabecular microstructure, predominantly in females
Elimination of LOXL1 in mice impairs the blood-aqueous humor barrier in the ocular anterior segment and causes lens abnormalities consistent with cataract formation, but does not result in deposition of macromolecular material or glaucoma.
There is a possible fundamental role of LOXL-1 in cardiac hypertrophy.
loxl appears non-allelic to rough coat in mice; heart- and skin-specific downregulation of LOXL in rough coat mice, however, may contribute to the extracellular matrix alterations and the rough coat phenotype
Data report that cells in the hippocampal granule cell layer of LOXL -/- mice have significantly smaller somas and muted long-term potentiation compared to LOXL +/+ mice.
pro-regions of lysyl oxidase (show LOX ELISA Kits) and lysyl oxidase-like 1 are required for deposition onto elastic fibers
LOXL1 deficiency caused failure of elastic fiber homeostasis leading to pelvic floor disorders
LOXL1 (lysyl oxidase-like 1) mutation results in a global defect in connective tissues and correlates with altered biomechanical behavior of the vagina and supportive tissues
LOXL1-KO lower urogenital tract anatomical and functional phenotype resembles female pelvic floor dysfunction in humans. Elastin (show ELN ELISA Kits) disorganization may lead to such functional abnormalities.
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
lysyl oxidase-like 1
, lysyl oxidase homolog 1-like
, lysyl oxidase homolog 1
, lysyl oxidase-like protein 1
, lysyl oxidase 2