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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Additionally we are shipping Lysyl-tRNA Synthetase Antibodies (76) and Lysyl-tRNA Synthetase Proteins (10) and many more products for this protein.
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The studies showed that mutations in KARS lead to a newly defined subtype of leukoencephalopathy associated with sensorineural hearing impairment. The combined effect of reduced aminoacylation and release of LysRS from the multiple-synthetase complex (MSC (show MSC ELISA Kits)) likely underlies the pathogenesis of the KARS mutations identified in this study.
Using the TruSight One sequencing panel we identified two novel mutations in KARS. Both mutations, never reported previously, occur in a highly conserved region of the catalytic domain and displayed a dramatic effect on KARS stability
Caspase-8 (show CASP8 ELISA Kits) controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from colorectal cancer cells.
Results indicate that KRS can promote cell-cell and cellextracellular matrix adhesion for migration.
finding show that enzymatically active Shiga toxins trigger the dissociation of lysyl-tRNA synthetase (KRS) from the multi-aminoacyl-tRNA synthetase complex in human macrophage-like differentiated THP-1 (show GLI2 ELISA Kits) cells and its subsequent secretion.
KRS at the plasma membrane plays new roles in metastatic migration as a signaling inducer, and causes intracellular signaling for cancer dissemination
tRK1 (show NTRK1 ELISA Kits) forms a complex with human enolases and interacts with tRK1 (show NTRK1 ELISA Kits) and human pre-lysyl-tRNA synthetase (preKARS2)
structural characteristics of the KRS-LR interaction on the cell surface
Lysyl-tRNA synthetase plays essential role in HIV replication, transcriptional regulation, cytokine-like signaling. [review]
The KARS variant is identified in two families affected by DFNB89-associated autosomal-recessive nonsyndromic hearing impairment.
mitoKARS is the first described member of a group of mitochondrial proteins whose interaction with mutant SOD1 contributes to mitochondrial dysfunction in ALS
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, lysine--tRNA ligase
, lysyl-tRNA synthetase
, lysine tRNA ligase