anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) Antibodies

MARK2 encodes a member of the Par-1 family of serine/threonine protein kinases. Additionally we are shipping MAP/microtubule Affinity-Regulating Kinase 2 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MARK2 2011 Q7KZI7
MARK2 13728 Q05512
MARK2 60328 O08679
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Top anti-MAP/microtubule Affinity-Regulating Kinase 2 Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN334431 (0.3µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of MARK2 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of MARK2 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Cow Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$533.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from COS7 cells, using MARK2 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of A549 cells, using MARK2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged MARK2 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IP, WB Western Blot: MARK2 Antibody [NBP1-71890] - Whole cell lysate from 293T (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and Jurkat (J; 50 mcg) cells. Affinity purified rabbit anti-MARK2 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. MARK2 was also immunoprecipitated by rabbit anti-MARK2 antibody NBP1-71889, which recognizes an upstream epitope. 100 μL Log in to see 7 to 9 Days
$556.31
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MARK2 (Ab-596) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using MARK2 (Ab-596) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-EMK Antibody (C-term)(ABIN392538) in mouse thymus tissue lysates (35 µg/lane). EMK(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB   200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details

MARK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MAP/microtubule Affinity-Regulating Kinase 2 Antibodies

  1. Human Polyclonal MARK2 Primary Antibody for ELISA, WB - ABIN314316 : Depasquale, Thompson: Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF. in Histopathology 2008 (PubMed)

  2. Human Monoclonal MARK2 Primary Antibody for ELISA, WB - ABIN560734 : Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. in Molecular and cellular biology 2008 (PubMed)

  3. Human Polyclonal MARK2 Primary Antibody for IP, WB - ABIN4332738 : Kruse, Krantz, Barker, Coletta, Rafikov, Luo, Højlund, Mandarino, Langlais: Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein. in Molecular & cellular proteomics : MCP 2017 (PubMed)

  4. Human Polyclonal MARK2 Primary Antibody for IHC (p), WB - ABIN392538 : Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001 (PubMed)
    Show all 2 Pubmed References

More Antibodies against MAP/microtubule Affinity-Regulating Kinase 2 Interaction Partners

Human MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) interaction partners

  1. In this study, through quantitative analysis of the complex formation between CagA (show S100A8 Antibodies) and PAR1b, the authors found that several CagA (show S100A8 Antibodies) species have acquired elevated PAR1b-binding activity via duplication of the CagA (show S100A8 Antibodies) multimerization motifs, while others have lost their PAR1b-binding activity.

  2. In the modeled structure of inactive MARK2, activation segment occludes the enzyme active site and assumes a relatively stable position.

  3. In conclusion, baicalin and DDP (show TIMM8A Antibodies) were synergistic at inhibiting proliferation and invasion of human lung cancer cells at appropriate dosages and incubation time in the presence or absence of DDP (show TIMM8A Antibodies) resistance. The attenuation of DDP (show TIMM8A Antibodies) resistance was associated with downregulation of MARK2 and p-Akt (show AKT1 Antibodies).

  4. MARK2 plays a role in promoting malignant phenotypes of lung cancer.

  5. Phosphorylation of RNF41 (show RNF41 Antibodies) by Par-1b regulates basolateral membrane targeting of laminin-111 receptors.

  6. induces asymmetric inheritance of plasma membrane domains via LGN (show GPSM2 Antibodies)-dependent mitotic spindle orientation in proliferating hepatocytes

  7. Perturbation of PAR1b and SHP2 (show PTPN11 Antibodies) by CagA (show S100A8 Antibodies) underlies the oncogenic potential of CagA (show S100A8 Antibodies).

  8. The MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.

  9. Hepatocyte Par1b defines lumen position in concert with the position of the astral microtubule anchoring complex LGN (show GPSM2 Antibodies)-NuMA (show NUMA1 Antibodies) to yield the distinct epithelial division phenotypes.

  10. automated image analysis of MT assembly dynamics identified MARK2 as a target regulated downstream of Rac1 that promotes oriented MT growth in the leading edge to mediate directed cell migration.

Mouse (Murine) MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) interaction partners

  1. These results indicate that the basal localization of Par-1b in the outer epithelial cells is required for myoepithelial cell compression, and Par-1b is required for myoepithelial differentiation, regardless of its localization.

  2. data suggest ectopic PAR1 (show F2R Antibodies) expression is not tolerated in mouse platelets and indicate a different approach is required to develop a small animal model for the purpose of any future preclinical testing of PAR (show AFG3L2 Antibodies) antagonists as anti-platelet drugs

  3. a model whereby MARK2 negatively regulates insulin (show INS Antibodies) sensitivity in peripheral tissue through inhibition of KSR1 (show KSR1 Antibodies)

  4. ROCK1 (show ROCK1 Antibodies)/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.

  5. PAR1b plays a novel role in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of p140Cap (show SRCIN1 Antibodies) in dendritic spines.

  6. Par-1b is a regulator of glucose metabolism and adiposity in the whole animal

  7. Interaction of MARK2 with CaMKI (show CAMK1 Antibodies) results in a novel, calcium-dependent pathway that plays an important role in neuronal differentiation.

  8. Akt (show AKT1 Antibodies) enhances the activity of PAR1 (show F2R Antibodies) to promote tau hyperphosphorylation at S262/S356, a tau species that is not recognized by the CHIP/Hsp90 (show HSP90 Antibodies) complex

  9. Coreduction of MARK2 and DCX (show DCX Antibodies) resulted in a partial restoration of the normal neuronal migration phenotype in vivo. The kinetic behavior of the centrosomes reflected the different molecular mechanisms activated when either protein was reduced.

MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) Antigen Profile

Protein Summary

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MARK2

  • microtubule affinity regulating kinase 2 (MARK2) antibody
  • MAP/microtubule affinity regulating kinase 2 (Mark2) antibody
  • microtubule affinity regulating kinase 2 (Mark2) antibody
  • AU024026 antibody
  • Emk antibody
  • EMK-1 antibody
  • EMK1 antibody
  • mKIAA4207 antibody
  • Par-1 antibody
  • Par-1b antibody
  • Par1b antibody

Protein level used designations for MARK2

ELKL motif kinase 1 , PAR1 homolog b , Ser/Thr protein kinase PAR-1B , serine/threonine protein kinase EMK , serine/threonine-protein kinase MARK2 , EMK-1 , EMK1 , serine/threonine kinase

GENE ID SPECIES
100049882 Equus caballus
2011 Homo sapiens
13728 Mus musculus
483769 Canis lupus familiaris
535197 Bos taurus
60328 Rattus norvegicus
100737238 Sus scrofa
100731733 Cavia porcellus
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