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MARK2 Products

(MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Categories

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009].

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Featured MARK2 Categories

MARK2 Antibodies

High quality antibodies with extensive validation data.

MARK2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MARK2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
  • (5)
Cat. No. ABIN560734
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC, ELISA, WB
Validations
  • (5)
Cat. No. ABIN3031689
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, ICC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN6258272
Quantity 100 μL
Datasheet Datasheet

Recommended MARK2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6219503
Quantity 96 tests
Datasheet Datasheet

Recommended MARK2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (2)
Cat. No. ABIN5570630
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093720
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134830
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MARK2 products

Parker, Krantz, Kwak, Barker, Deer, Lee, Mouneimne, Langlais: "Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-end Tracking Protein Network in Adipocytes." in: Molecular & cellular proteomics : MCP, Vol. 18, Issue 7, pp. 1363-1381, (2019) (PubMed).

Kruse, Krantz, Barker, Coletta, Rafikov, Luo, Højlund, Mandarino, Langlais: "Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein." in: Molecular & cellular proteomics : MCP, Vol. 16, Issue 10, pp. 1718-1735, (2017) (PubMed).

Yoshiike, Yamashita, Mizoroki, Maeda, Murayama, Kimura, Sahara, Soeda, Takashima: "Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes." in: Aging cell, Vol. 11, Issue 1, pp. 51-62, (2012) (PubMed).

Hezel, Gurumurthy, Granot, Swisa, Chu, Bailey, Dor, Bardeesy, Depinho: "Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2414-25, (2008) (PubMed).

Depasquale, Thompson: "Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF." in: Histopathology, Vol. 52, Issue 4, pp. 500-9, (2008) (PubMed).

Hurov, Watkins, Piwnica-Worms: "Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity." in: Current biology : CB, Vol. 14, Issue 8, pp. 736-41, (2004) (PubMed).

Hueso, Beltran, Moreso, Ciriero, Fulladosa, Grinyó, Serón, Navarro et al.: "Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of ..." in: Biochimica et biophysica acta, Vol. 1689, Issue 1, pp. 58-65, (2004) (PubMed).

Cantrell: "Phosphoinositide 3-kinase signalling pathways." in: Journal of cell science, Vol. 114, Issue Pt 8, pp. 1439-45, (2001) (PubMed).

Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, (2001) (PubMed).

Sun, Lu, Feng, Reinhard, Jan, Fantl, Williams: "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling." in: Nature cell biology, Vol. 3, Issue 7, pp. 628-36, (2001) (PubMed).

Synonyms and alternative names related to MARK2

microtubule affinity regulating kinase 2 (MARK2), MAP/microtubule affinity regulating kinase 2 (Mark2), microtubule affinity regulating kinase 2 (Mark2), AU024026, Emk, EMK-1, EMK1, mKIAA4207, PAR-1, Par-1, Par-1b, Par1b

Protein level used designations for MARK2

  • ELKL motif kinase 1
  • PAR1 homolog b
  • Ser/Thr protein kinase PAR-1B
  • serine/threonine protein kinase EMK
  • serine/threonine-protein kinase MARK2
  • EMK-1
  • EMK1
  • serine/threonine kinase
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