MDS1 and EVI1 Complex Locus Proteins (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (125) and MDS1 and EVI1 Complex Locus Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Rat MECOM MECOM 294924  
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Top MDS1 and EVI1 Complex Locus Proteins at antibodies-online.com

Showing 4 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,984.89
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag 0.5 mg Log in to see 13 to 16 Days
$953.85
Details

MECOM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for MDS1 and EVI1 Complex Locus (MECOM) Interaction Partners

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. The relationship between EVI1 and microRNAs in human malignancies. [review]

  2. Fisher's exact SubID was used to reveal EVI1 as a transcriptional regulator of INPP4B in AML; a finding which was validated in vitro. Next, we used CoxPH SubID to conduct a pan-cancer analysis of INPP4B's prognostic significance

  3. Letter/Case Report: ETV6 (show ETV6 Proteins)/MECOM gene fusion in therapy-related acute myeloid leukemia (show BCL11A Proteins) with t(3;12) and monosomy 7.

  4. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  5. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (show ETS1 Proteins)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  6. The expression of EVI1 and SOX9 (show SOX9 Proteins) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (show FRAP1 Proteins) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (show FRAP1 Proteins) targeting failure

  7. EVI1 contributes to PCa (show FLVCR1 Proteins) progression by regulating different oncogenic functions. EVI1 regulates the PCa (show FLVCR1 Proteins) stem cell compartment responsible for disease initiation and also development of CRPC.

  8. oncogenic potential for EVI1 in modulating genomic stability

  9. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  10. EVI1 overexpression alters cellular metabolism. EVI1 promotes CKMT1 (show CKMT1B Proteins) expression by repressing the myeloid differentiation regulator RUNX1 (show RUNX1 Proteins).

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  2. Gata2 (show GATA2 Proteins) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  3. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  4. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (show CEBPA Proteins) from EVI1-induced suppression.

  5. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Proteins), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Proteins) levels.

  6. Survivin (show BIRC5 Proteins) partially regulates HSC (show FUT1 Proteins) function by modulating the Evi-1 transcription factor and its downstream targets

  7. Thrombopoietin (show THPO Proteins)/MPL (show MPL Proteins) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  8. Prdm16 (show PRDM16 Proteins) and Prdm3 control postnatal BAT (show BAAT Proteins) identity and function.

  9. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  10. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Proteins)) fusion protein (MFP) leukemia

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Proteins) signaling

  2. Prdm3 and prdm16 (show PRDM16 Proteins) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi-1 (show RUNX1 Proteins) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) Protein Profile

Protein Summary

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (Mecom)
  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus L homeolog (mecom.L)
  • AML1-EVI-1 protein
  • D630039M04Rik protein
  • evi-1 protein
  • evi1 protein
  • im:7140716 protein
  • Jbo protein
  • Mds protein
  • Mds1 protein
  • Mds1-Evi1 protein
  • mecom protein
  • mecom-a protein
  • mecom-b protein
  • prdm3 protein
  • xEvi-1 protein
  • Znfpr1b1 protein

Protein level used designations for MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPECIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
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