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Meningioma 1 (MN1) contains two sets of CAG repeats.
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The data obtained show that normal cells consistently express low levels of MN1 transcript. In contrast, high levels of MN1 expression are present in 47% of patients with normal karyotype and in all cases with inv (show INVS Proteins)(16).
Patients with t(12;22)/MN1-EVT6 oncogene (show RAB1A Proteins), are frequently associated with myeloid neoplasms, poor response to chemotherapy, and inferior outcome.
MN1 gene expression in acute myeloid leukemia (show BCL11A Proteins).
MN1 deletion is associated with Craniofacial Abnormalities.
Chromosome 22q12.1 microdeletions involving the MN1 gene confirm it as a candidate gene for cleft palate.
MLL1 and DOT1L (show DOT1L Proteins) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).
genotype-phenotype correlation among our patients and those previously reported with overlapping 22q12 deletions, we identified a 560 kb critical region containing the MN1 gene that is implicated in human cleft palate formation
these results suggest that deregulated MN1 expression contributes to the pathogenesis of pediatric B-ALL.
identified potential driver mutations in NF2 (neurofibromatosis type 2) and MN1 (meningioma 1).
cotransduction of an activated HOX (show MSH2 Proteins) gene (NUP98HOXD13) with MN1 induces a serially transplantable acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)).
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4\\;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis.
meningioma (translocation balanced)
, meningioma chromosome region 1
, probable tumor suppressor protein MN1