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MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of MSR1.
Showing 9 out of 24 products:
Human Macrophage Scavenger Receptor 1 ELISA Kit for Sandwich ELISA - ABIN417678
Zuo, Yu, Guo, Wang, Qian, Yi, Lu, Lv, Subjeck, Zhou, Sanyal, Chen, Wang: Scavenger receptor A restrains T-cell activation and protects against concanavalin A-induced hepatic injury. in Hepatology (Baltimore, Md.) 2013
Decreased expression by OxLDL in PMA-differentiated THP-1 (show GLI2 ELISA Kits) macrophages. Increased expression in plaque vs. nonplaque lesion areas in human carotid endarterectomy specimens (correlated with CD36 (show CD36 ELISA Kits) expression).
Cytokine abnormality induced by SRA(+) cells playS an role in tissue injury, and platelet emboli or contraction band necrosis might have been the leading cause of death in our SUDI cases.
TGM2 (show TGM2 ELISA Kits) has a role in macrophage differentiation via mechanisms involving CD14 and SR-AI receptors.
study demonstrates the elevated SR-A expression on cell surface contributes to increased susceptibility to Adenovirus serotype 5 (Ad5 (show PSEN2 ELISA Kits)) infection into CD14+ monocytes; SR-A-mediated Ad5 (show PSEN2 ELISA Kits) entry, TLR3 (show TLR3 ELISA Kits) signaling activation and acLDL accumulation in monocytes/ macrophages synergistically trigger the inflammatory responses and innate immunity against Ad5 (show PSEN2 ELISA Kits) infection
SR-A1 expression in 136 human gliomas was positively correlated with tumor grade (P<0.01), but not prognosis or tumor recurrence
The results reveal marked differences between afferent and efferent ymphatic endothelial cells and identify molecules on lymphatic vessels. Further characterizations of Siglec-1 (CD169 (show SIGLEC1 ELISA Kits)) and macrophage scavenger receptor 1 (MSR1/CD204), show that they are discriminatively expressed on lymphatic endothelium of the subcapsular sinus but not on lymphatic vasculature of the lymphatic sinus
SR-A1 suppresses lung cancer metastasis by downregulating SAA1 (show SAA1 ELISA Kits) production in tumor-associated macrophages (TAM (show CCNA1 ELISA Kits)).
PTX2 (show APCS ELISA Kits) was identified PTX2 (show APCS ELISA Kits) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
we found that higher percentages of circulating CD14+CD204+, CD14+CD163+CD204+ M2-like monocytes were significantly associated with TNM stage, lymph node metastasis, and histological differentiation.
Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO (show MARCO ELISA Kits).
TMP upregulated the protein stability of ABCA1 (show ABCA1 ELISA Kits) without affecting ABCG1 (show ABCG1 ELISA Kits). Accordingly, TMP regulated the expression of SR-A, CD36 (show CD36 ELISA Kits), ABCA1 (show ABCA1 ELISA Kits) and ABCG1 (show ABCG1 ELISA Kits) in aortas of ApoE (show APOE ELISA Kits)-/- mice, which resembled the findings observed in macrophages.
LPS (show TLR4 ELISA Kits) may increase Ac-LDL uptake and enhance CD204 expression through MAPK/ERK (show MAPK1 ELISA Kits) activation in bone marrow-derived macrophages.
The low magnitude of opsonin-independent phagocytosis of Escherichia coli and unimpaired phagocytosis of Staphylococcus aureus in SR-A- or CD36 (show CD36 ELISA Kits)-deficient macrophages indicate that the defect in this process might not be responsible for the reported impaired bacteria clearance in mice deficient in these receptors.
Data (including data from studies conducted in cells from knockout mice) suggest that signaling via Lpar1 (show LPAR1 ELISA Kits), Cd14 (show CD14 ELISA Kits), and Scara1 mediates uptake of oxidized LDL by macrophages leading to foam cell formation; lysophosphatidic acid (LPA (show LPA ELISA Kits)) induces expression of Cd14 (show CD14 ELISA Kits) and Scara1 in macrophages. (Lpar1 (show LPAR1 ELISA Kits) = LPA receptor 1 (show LPAR1 ELISA Kits); Cd14 (show CD14 ELISA Kits) = monocyte differentiation antigen CD14 (show CD14 ELISA Kits); Scara1 = scavenger receptor class A type I)
Common damage-associated molecular patterns (DAMPs) were internalized through the class A scavenger receptors MSR1 and MARCO (show MARCO ELISA Kits) in vitro. In ischemic murine brain, DAMP (show AMPH ELISA Kits) internalization was largely mediated by MSR1. Combined deficiency for Msr1 and Marco (show MARCO ELISA Kits) in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
PTX2 (show PITX2 ELISA Kits) was identified PTX2 (show PITX2 ELISA Kits) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
this study shows that Msr1 functions as co-receptor along with TLRs for HMGB1 (show HMGB1 ELISA Kits) in M1-type inflammatory macrophages
Our findings demonstrated that ClC-3 (show CLCN3 ELISA Kits) deficiency inhibits atherosclerotic lesion development, possibly via suppression of JNK (show MAPK8 ELISA Kits)/p38 MAPK (show MAPK14 ELISA Kits) dependent SR-A expression and foam cell formation
FAP (show FAP ELISA Kits)-cleaved collagen is a substrate for SR-A-dependent macrophage adhesion.
Macrophages regulate FX plasma levels in an SR-AI-dependent manner.
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
macrophage acetylated LDL receptor I and II
, macrophage scavenger receptor type III
, macrophage scavenger receptor types I and II
, scavenger receptor class A member 1
, scavenger receptor class A, member 1
, scavenger receptor type A
, macrophage scavenger receptor 1
, macrophage scavenger receptor type I
, macrophage scavenger receptor types I and II-like