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The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Additionally we are shipping MST1 Kits (45) and MST1 Proteins (15) and many more products for this protein.
Showing 10 out of 101 products:
Human Monoclonal MST1 Primary Antibody for IF, WB - ABIN968344
Creasy, Chernoff: Cloning and characterization of a human protein kinase with homology to Ste20. in The Journal of biological chemistry 1995
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Human Polyclonal MST1 Primary Antibody for IHC (p), WB - ABIN392427
Ren, Yan, You, Sun: Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells. in Cancer research 2008
Show all 2 Pubmed References
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1/2)/YAP (show YAP1 Antibodies) signaling, and that inhibition of miR (show MLXIP Antibodies)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (show SOX2 Antibodies) and SALL4 (show SALL4 Antibodies).
These data suggest that MSP (show MSMB Antibodies) is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP (show MSMB Antibodies) has a key regulatory role in non-alcoholic steatohepatitis.
Study found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin (show INS Antibodies) secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1 (show PDX1 Antibodies)), which is critical for insulin (show INS Antibodies) production.
deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA) manner in promotion of breast cancer growth.
TNFAIP8 (show TNFAIP8 Antibodies) regulates Hippo (MST1/2) signaling through its interaction with LATS1 (show LATS1 Antibodies).
Data suggest that Hippo (MST1/2 protein kinases) - Yes associated protein 1 (YAP (show YAP1 Antibodies)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
our results identified that mammalian sterile 20-like kinase 1 (show STK4 Antibodies) is a novel downstream target of pyruvate kinase M2, and knockdown of pyruvate kinase M2 contributes apoptosis via promoting nuclear translocation of mammalian sterile 20-like kinase 1 (show STK4 Antibodies) by enhancing Caspase-3 (show CASP3 Antibodies)-dependent cleavage.
H-ras (show HRAS Antibodies), via an Erk (show EPHB2 Antibodies)-dependent mechanism, downregulates Mst1/Mst2 (show STK3 Antibodies) activity by inducing the formation of inactive Mst1/Mst2 (show STK3 Antibodies) heterodimers.
Mst1 as a novel physiological negative regulator of IRF3 (show IRF3 Antibodies) activation provides mechanistic insights into innate antiviral defense and potential antiviral prevention strategies.
Mst1 increases the (show FOXP3 Antibodies)acetylation of Foxp3 by inhibiting Sirt1 activity, which requires the Mst1 kinase activity.
These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.
kinases, including Slk (show SLK Antibodies), Lok (show STK10 Antibodies) and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 (show LATS1 Antibodies) increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 Antibodies) target genes and hepatocyte proliferation.
The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation (show BLNK Antibodies).
Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes.
these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect
Results identify L-plastin (show LCP1 Antibodies) as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein (show PFN1 Antibodies) critical to T cell migration.
MIST1 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architecture
Mst1 deficiency diminishes atherosclerosis and stabilizes atherosclerotic plaques in ApoE (show APOE Antibodies)(-/-) mice. Mst1 may participate in atherosclerosis progression through inhibition of macrophage autophagy and promotion of macrophage apoptosis.
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, hepatocyte growth factor-like protein
, hepatocyte growth factor-like protein homolog
, macrophage-stimulating protein
, E2F transcription factor 2
, macrophage stimulatory protein
, hepatocyte growth factor-like/macrophage stimulating protein
, macrophage stimulating 1 (hepatocyte growth factor-like)
, 12S E1A
, macrophage stimulating 1 L homeolog