anti-Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) Antibodies

The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Additionally we are shipping MST1 Kits (49) and MST1 Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MST1 4485 P26927
MST1 24566  
MST1 15235 P26928
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Top anti-MST1 Antibodies at antibodies-online.com

Showing 10 out of 100 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB Immunohistochemistry with Liver tissue at an antibody concentration of 5µg/ml using anti-MST1 antibody (ARP45724_P050) WB Suggested Anti-MST1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Host: Rabbit Target Name: MST1 Sample Type: Thymus Tumor lysates Antibody Dilution: 1.0ug/ml Rabbit Anti-MST1 Antibody Catalog Number: ARP45722_P050 Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue Observed Staining: Cytoplasm in hepatocytes Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB MST1 Antibody (C-term)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MST1 antibody detected the MST1 protein (arrow). MST1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MST1 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6270145 at 1/100 staining mouse heart tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6270145 at 1/100 staining rat heart tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-MST1 Pab (ABIN392427) in HL60 cell lysate. MST1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Western blot analysis of STK4 (arrow) using MST1 Antibody (C-term) (ABIN392427).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the STK4 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-CMST1 Polyclonal Antibody, Unconjugated (ABIN747308) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details
Dog Rabbit Un-conjugated IHC, IHC (p), WB Anti-MST1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN958312 concentration 5 ug/ml. Anti-MST1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms ... 100 μL Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated IHC, WB ABIN6267141 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of WEHI-231 cells treated with Staurosporine, using Phospho-MST1 (Thr183)/MST2 (Thr180) Antibody. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow cytometric analysis of NCI-H460 cells using MST1 Antibody (C-term) Cat.-No AP52761PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue reacted with MST1 Antibody (C-term) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining.This data demonstrates the use of MST1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of MST1 using 293 whole cell lysates ABIN6278391 at 1/100 staining Human pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details

Top referenced anti-MST1 Antibodies

  1. Human Polyclonal MST1 Primary Antibody for IHC (p), WB - ABIN392427 : Ren, Yan, You, Sun: Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells. in Cancer research 2008 (PubMed)
    Show all 2 Pubmed References

More Antibodies against MST1 Interaction Partners

Human Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) interaction partners

  1. Legionella pneumophila effector protein LegK7(lpg1924) hijacks the conserved Hippo signaling pathway by molecularly mimicking host Hippo kinase (MST1 in mammals), which is the key regulator of pathway activation.

  2. Mst1 has an important role in inhibiting the growth of NSCLC in vitro and in vivo; its antiproliferative effect is associated with induction of apoptosis.

  3. These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.

  4. Identify MST1/MSP as a mitogen for tracheal basal cells.

  5. MSP appears to promote the migration of fibroblasts, enhances collagen synthesis and remodeling, and effectively improves wound healing.

  6. Elevated serum levels of MST1 were found in subjects with excessive alcohol use.

  7. These results support the hypothesis that the alpha-chain of MSPalphabeta mediates RON dimerization.

  8. functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele

  9. Results suggest that the [AA] genotype of the common MST1 variant rs3197999 enhances genetic risk of sporadic extrahepatic cholangiocarcinoma irrespective of primary sclerosing cholangitis status.

  10. MSP may be one of the major determinants that affects the properties of tumor stroma and that produces a permissive microenvironment to promote cancer metastasis

  11. The present results refine the known genetic architecture in primary sclerosing cholangitis by confirming MST1 locus association.

  12. the missense SNP impairs MSP function by reducing its affinity to RON and perhaps through a secondary effect on in vivo concentration arising from reduced thermodynamic stability, resulting in down-regulation of the MSP/RON signaling pathway.

  13. HAT cleaves proMSP at the physiological activation site

  14. Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4).

  15. These findings suggest that the MSP/RON signaling pathway may be regulated by hepsin in tissue homeostasis and in disease pathologies, such as in cancer and immune disorders.

  16. considerable number of Merkel cell carcinoma cases expressed both RON and MSP, while Merkel cells do not express these molecules

  17. MSP-induced RSK2 activation is a critical determinant linking RON signaling to cellular EMT program.

  18. the oncogenic effect of BRAF(V600E) is associated with the inhibition of MST1 tumor suppressor pathways, and that the activity of RASSF1A-MST1-FoxO3 pathways determines the phenotypes of BRAF(V600E) tumors.

  19. results suggest that MSP induces uPAR expression via MAPK, AP-1 and NF-kappaB signaling pathways

  20. These results suggest that activation of RON by macrophage-stimulating protein inhibits LPS-induced macrophage Cox-2 expression.

Mouse (Murine) Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like) (MST1) interaction partners

  1. our results implicate Mst1 upregulation as a critical step in exacerbating HFD-mediated hepatic injury. Increased Mst1 blocks the AMPK pathway and thus diminishes Parkin expression, repressing mitophagy and consequently activating mitochondrial apoptosis in HFD-treated livers.

  2. data revealed that OSM alleviated postinfarction cardiac remodeling and dysfunction by enhancing cardiomyocyte autophagy. OSM holds promise as a therapeutic target in treating HF after MI through Obeta receptor by inhibiting Mst1 phosphorylation.

  3. The results identify Mst1 as a malefactor in the development of post-infarction cardiac injury and that it acts through the JNK-Drp1-mitochondrial fission pathway.

  4. The results suggest that melatonin alleviates cardiac remodeling and dysfunction in diabetic cardiomyopathy by upregulating autophagy, limiting apoptosis, and modulating mitochondrial integrity and biogenesis. The mechanisms are associated with Mst1/Sirt3 signaling.

  5. These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.

  6. kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.

  7. Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.

  8. Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 target genes and hepatocyte proliferation.

  9. The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation.

  10. Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes.

  11. these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect

  12. Results identify L-plastin as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein critical to T cell migration.

  13. MIST1 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architecture

  14. Mst1 deficiency diminishes atherosclerosis and stabilizes atherosclerotic plaques in ApoE(-/-) mice. Mst1 may participate in atherosclerosis progression through inhibition of macrophage autophagy and promotion of macrophage apoptosis.

  15. These results suggest that melatonin alleviates postinfarction cardiac remodeling and dysfunction by upregulating autophagy, decreasing apoptosis, and modulating mitochondrial integrity and biogenesis. The attributed mechanism involved, at least in part, Mst1/Sirt1 signaling

  16. TRAF2 functions as a key activator of MST1 in oxidative stress-induced intracellular signaling processes.

  17. Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.

  18. Mst1 enhances Foxp3 expression and Treg function at the post-translational level.

  19. our study demonstrates the existence of a direct crosstalk between mTORC2 and MST1 that is critical for cardiac cell survival and growth.

  20. Mst1 regulates Myosin IIa dynamics to organize high and low affinity LFA-1 to the anterior and posterior membrane during T cell migration.

MST1 Antigen Profile

Protein Summary

The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.

Gene names and symbols associated with MST1

  • macrophage stimulating 1 (MST1) antibody
  • macrophage stimulating 1 (Mst1) antibody
  • macrophage stimulating 1 (hepatocyte growth factor-like) (Mst1) antibody
  • macrophage stimulating 1 (hepatocyte growth factor-like) (MST1) antibody
  • macrophage stimulating 1 L homeolog (mst1.L) antibody
  • d3f15s2 antibody
  • D3F15S2h antibody
  • D9H3F15S2 antibody
  • dnf15s2 antibody
  • DNF15S2h antibody
  • E1A antibody
  • E2F2 antibody
  • HGF1/MSP antibody
  • hgfl antibody
  • msp antibody
  • mst1 antibody
  • nf15s2 antibody
  • XHL antibody

Protein level used designations for MST1

hepatocyte growth factor-like protein , hepatocyte growth factor-like protein homolog , macrophage-stimulating protein , D8h3f15s2 , E2F transcription factor 2 , MSP , macrophage stimulatory protein , hepatocyte growth factor-like/macrophage stimulating protein , macrophage stimulating 1 (hepatocyte growth factor-like) , 12S E1A , macrophage stimulating 1 L homeolog

GENE ID SPECIES
4485 Homo sapiens
24566 Rattus norvegicus
15235 Mus musculus
484768 Canis lupus familiaris
514667 Bos taurus
396135 Gallus gallus
100734937 Cavia porcellus
100512987 Sus scrofa
379214 Xenopus laevis
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