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The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Additionally we are shipping MST1 Antibodies (102) and MST1 Kits (48) and many more products for this protein.
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Mst1 has an important role in inhibiting the growth of NSCLC in vitro and in vivo; its antiproliferative effect is associated with induction of apoptosis.
These data suggest that MSP (show MSMB Proteins) is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP (show MSMB Proteins) has a key regulatory role in non-alcoholic steatohepatitis.
Identify MST1/MSP as a mitogen for tracheal basal cells.
MSP (show MSMB Proteins) appears to promote the migration of fibroblasts, enhances collagen synthesis and remodeling, and effectively improves wound healing.
Elevated serum levels of MST1 were found in subjects with excessive alcohol use.
These results support the hypothesis that the alpha-chain (show FCGRT Proteins) of MSPalphabeta mediates RON (show MST1R Proteins) dimerization.
functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele
Results suggest that the [AA] genotype of the common MST1 variant rs3197999 enhances genetic risk of sporadic extrahepatic cholangiocarcinoma irrespective of primary sclerosing cholangitis status.
MSP (show MSMB Proteins) may be one of the major determinants that affects the properties of tumor stroma and that produces a permissive microenvironment to promote cancer metastasis
The present results refine the known genetic architecture in primary sclerosing cholangitis by confirming MST1 locus association.
data revealed that OSM (show OSM Proteins) alleviated postinfarction cardiac remodeling and dysfunction by enhancing cardiomyocyte autophagy. OSM (show OSM Proteins) holds promise as a therapeutic target in treating HF after MI through Obeta receptor by inhibiting Mst1 phosphorylation.
The results identify Mst1 as a malefactor in the development of post-infarction cardiac injury and that it acts through the JNK (show MAPK8 Proteins)-Drp1 (show CRMP1 Proteins)-mitochondrial fission pathway.
The results suggest that melatonin alleviates cardiac remodeling and dysfunction in diabetic cardiomyopathy by upregulating autophagy, limiting apoptosis, and modulating mitochondrial integrity and biogenesis. The mechanisms are associated with Mst1/Sirt3 (show SIRT3 Proteins) signaling.
These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.
kinases, including Slk (show SLK Proteins), Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 Proteins) target genes and hepatocyte proliferation.
The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation (show BLNK Proteins).
Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes.
these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
hepatocyte growth factor-like protein
, hepatocyte growth factor-like protein homolog
, macrophage-stimulating protein
, E2F transcription factor 2
, macrophage stimulatory protein
, hepatocyte growth factor-like/macrophage stimulating protein
, macrophage stimulating 1 (hepatocyte growth factor-like)
, 12S E1A
, macrophage stimulating 1 L homeolog