Major Intrinsic Protein of Lens Fiber (MIP) ELISA Kits

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. Additionally we are shipping MIP Antibodies (57) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MIP 4284 P30301
MIP 17339 P51180
MIP 25480  
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Top MIP ELISA Kits at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
Mouse 0.469 ng/mL 0.781-50 ng/mL Typical standard curve 96 Tests 12 to 14 Days
$630.00
Details
Rabbit 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Guinea Pig 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Human 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Rat 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Dog 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Monkey 1.0 ng/mL 5.0-100 ng/mL   96 Tests 15 to 18 Days
$707.14
Details
Pig
  96 Tests 15 to 18 Days
$707.14
Details
Goat
  96 Tests 15 to 18 Days
$707.14
Details
Cow
  96 Tests 15 to 18 Days
$707.14
Details

More ELISA Kits for MIP Interaction Partners

Human Major Intrinsic Protein of Lens Fiber (MIP) interaction partners

  1. The novel missense mutation c.572C>Gp.P191Rat exon 3 of the MIP gene was identified in a Chinese family of congenital cataract. The mutation affects the traffic of MIP protein in the cells and reduces the expression level of MIP protein in the cell membrane.

  2. Our study generated genetic and primary functional evidence for a novel c.682_683delAA mutation in MIP that expands the variant spectrum of MIP and help us better understand the molecular basis of cataract.

  3. Study presented genetic and functional evidence for a novel major intrinsic protein mutation of G212R, which leads to congenital progressive cortical punctate with or without Y suture.

  4. In summary, whole-exome sequencing identifies a novel heterozygous missense variant (c.402G > T) in rarely reported cataract gene of MIP in an unconsanguineous marriage of three-generation Chinese family with congenital cataracts.

  5. The data evidence a broad lipidation profile of AQP0 that is both species and site independent, suggesting a chemical-based ester aminolysis mechanism to explain such modifications.

  6. A novel MIP frame-shift mutation in familial congenital nuclear cataract patient

  7. defects in AQP-0 permeability may be a cause for presbyopia.

  8. the p.D150H mutation is a novel disease-causing mutation in MIP, which leads to congenital progressive cortical punctate cataract by impairing the trafficking mechanism of AQP0.

  9. Authors identified a novel nonsense mutation in MIP (c.657 C>G; p.Y219*) (major intrinsic protein gene) that segregates with congenital posterior polar cataract in a Chinese family.

  10. Functional evidence linking the new MIP mutation of G215D to autosomal dominant congenital cataracts.

  11. A novel donor splice-site mutation (c.606+1G>A) in the MIP gene causes congenital cataract in a Chinese family.

  12. the first nonsense mutation of MIP identified in autosomal dominant congenital cataracts

  13. Mutation of this conserved glycine residue leads to improper trafficking of AQP0-G165D and loss of water channel function.

  14. Aquaporin 0 R233K mutation did not affect the expression, location and trafficking of the protein but did influence the interaction between AQP0 and CaM.

  15. Direct tissue analysis led to the detection of aging-related AQP0 modifications including carbamylation, acetylation, and oleoylation.

  16. Major intrinsic protein (MIP) polymorphism is associated with age-related cataract in Chinese.

  17. Cerulean cataract has been mapped to chromosome 12q13 and associated with a novel initiation codon mutation in MIP.

  18. A novel mutation in the MIP gene is associated with autosomal dominant congenital nuclear cataract in a Chinese family.

  19. analysis of a novel disease-causing mutation p.R187C in MIP in a Chinese cataract family

  20. AQP-0 gene expression was 3.4-fold higher in rat retinas. AQP-0 was predominantly expressed in the bipolar cells of the non-diabetic rat retinas, whereas it was also expressed in the retinal nerve fibers of diabetic rat retinas

Mouse (Murine) Major Intrinsic Protein of Lens Fiber (MIP) interaction partners

  1. positively charged amino acids in the AQP0 extracellular loop domains interact with the negatively charged lipids in the plasma membrane to promote cell-to-cell adhesion for compaction of fiber cells.

  2. Cataractogenesis in Mip(Nat) mutants are caused by defects in MIP expression.

  3. These data suggest that while relatively few genes ( approximately 1.5% of the transcriptome) were differentially regulated >2-fold in the Mip-/- lens, calpain hyper-activation acts as a terminal pathogenic event during lens fiber cell death and cataract formation.

  4. hypothesize that AQP0, with its prolific expression at the fiber cell membrane, could provide anchorage for cytoskeletal structures like BFs and together they help to confer fiber cell shape, architecture and integrity

  5. In summary, lens transparency, CTCA and compact packing of fiber cells were affected due to the loss of 50% AQP0 leading to larger extracellular space, more water content and SA, possibly due to alteration in RING.

  6. Post-translational truncation of N- or C-terminal end amino acids does not alter the basal water permeability of AQP0 or its adhesive functions.

  7. Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46.

  8. The additional negative charge introduced by phosphoserine 235 perturbs electrostatic interactions between aquaporin-0 and calmodulin to favour water influx through the channel.

  9. increased water permeability through AQP1 does not compensate for loss of AQP0 expression in TgAQP1(+/+)/AQP0(-/-) mice. Fiber cell AQP0 expression is required to maintain their organization, which is a requisite for lens transparency

  10. Kynurenine might inhibit FGF2-mediated fiber cell differentiation by preventing expression of crystallins and MIP26.

  11. MIP has essential roles in the establishment and maintenance of uniform fiber structure, and the organization of fibers, and as such is essential for lens function.

  12. study provides the first evidence that calcium regulation of AQP0 water permeability may be crucial for maintaining normal lens homeostasis and development

Cow (Bovine) Major Intrinsic Protein of Lens Fiber (MIP) interaction partners

  1. The data evidence a broad lipidation profile of AQP0 that is both species and site independent, suggesting a chemical-based ester aminolysis mechanism to explain such modifications.

  2. In the presence of alpha-crystallin, this conversion to beta-sheet is minimized, suggesting that the protein structure that binds to the molecular chaperone is mostly the alpha-helical structure of AQP0.

  3. Determined the pseudoatomic structure of full-length aquaporin-0 (AQP0) in complex with calmodulin, using electron microscopy to elucidate how this signaling protein modulates water-channel function.

  4. Tyr23 is a dominate factor leading to the low water permeability in AQP0.

  5. AQP-0 and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 homo-oligomerization

  6. determination of the x-ray structure of bovine aquaporin 0 to a resolution of 2.2 A; structure aids the analysis of the interaction of the extracellular domains and the possibility of a cell-cell adhesion role for AQP0

  7. The crystal packing was determined by molecular replacement and shows that, within the cubic lattice, AQP0 tetramers are associated head-to-head along their 4-fold axes.

Xenopus laevis Major Intrinsic Protein of Lens Fiber (MIP) interaction partners

  1. The proposed schematic models illustrate that cell-to-cell adhesion elicited by AQP0 is vital for lens transparency and homeostasis.

  2. A concentration signal could trigger a regulatory change in AQP0 water permeability.

Zebrafish Major Intrinsic Protein of Lens Fiber (MIP) interaction partners

  1. These results suggest that Aqp0a is the primary water channel of the lens and that Aqp0b, though possibly a secondary water channel, has an unidentified function in the lens.

MIP Antigen Profile

Antigen Summary

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.

Gene names and symbols associated with MIP

  • major intrinsic protein of lens fiber (MIP) antibody
  • major intrinsic protein of lens fiber (Mip) antibody
  • major intrinsic protein of lens fiber L homeolog (mip.L) antibody
  • major intrinsic protein of lens fiber (mip) antibody
  • major intrinsic protein of lens fiber a (mipa) antibody
  • aqp0 antibody
  • Cat antibody
  • CTRCT15 antibody
  • Hfi antibody
  • lim1 antibody
  • Lop antibody
  • MIP antibody
  • mip1 antibody
  • mip26 antibody
  • MP22 antibody
  • mp26 antibody
  • shrivelled antibody
  • Svl antibody
  • zgc:100858 antibody

Protein level used designations for MIP

aquaporin 0 , lens fiber major intrinsic protein , MP26 , aquaporin-0 , dominant cataract , hydropic fibers , lens opacity , MIP26 , major intrinsic protein of lens fiber , Aquaporin-0 , aquaporin , AQP0 , major intrinsic protein of eye lens fiber , aqp0a , aquaporin-0a , major intrinsic protein of lens fiber 1

GENE ID SPECIES
4284 Homo sapiens
17339 Mus musculus
280859 Bos taurus
495140 Xenopus laevis
100037914 Xenopus (Silurana) tropicalis
100135575 Cavia porcellus
100294602 Ovis aries
607104 Canis lupus familiaris
100101574 Oryctolagus cuniculus
374124 Gallus gallus
712901 Macaca mulatta
747083 Pan troglodytes
25480 Rattus norvegicus
445140 Danio rerio
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