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Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. Additionally we are shipping MDH2 Antibodies (85) and MDH2 Proteins (23) and many more products for this protein.
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Med24 and Mdh2 are required for Drosophila larval salivary gland cell death
his study suggests that MDH2 pathogenic variants may play a role in pheochromocytoma/paraganglioma (PPGL) susceptibility and that they might be responsible for less than 1% of PPGLs in patients without pathogenic variants in other major PPGL driver genes, a prevalence similar to the one recently described for other PPGL genes
these data suggest that MDH2, functioning as an RNA-binding protein, is involved in the posttranscriptional downregulation of SCN1A expression under seizure condition.
loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children
Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms.
Segregation of the mutation with disease and absence of MDH2 in mutated tumors revealed MDH2 as a novel pheochromocytoma/paraganglioma susceptibility gene.
L-2-hydroxyglutarate accumulates as a result of a deficiency in FAD-linked L-2-hydroxyglutarate dehydrogenase. mitochondrial L-malate dehydrogenase is responsible for the excretion of L-2-hydroxyglutarate in this condition.
Macromolecular crowding effects on MDH depend on the isozyme, reaction direction, and crowding agent. Crowding increases Km of mitochondrial MDH for malate oxidation.
The acetylation of MDH2 was affected by the cellular energy state and subsequently regulated adipogenic differentiation.
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.
mitochondrial malate dehydrogenase 2b
, mitochondrial malate dehydrogenase
, mitochondrial malate dehydrogenase 2, NAD
, malate dehydrogenase, mitochondrial
, malate dehydrogenase 2, mitochondrial