Malignant T Cell Amplified Sequence 1 Proteins (MCTS1)

The protein encoded by MCTS1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Additionally we are shipping Malignant T Cell Amplified Sequence 1 Antibodies (86) and Malignant T Cell Amplified Sequence 1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MCTS1 28985 Q9ULC4
MCTS1 68995 Q9DB27
MCTS1 302500 Q4G009
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Top Malignant T Cell Amplified Sequence 1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$860.20
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
$2,427.33
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,427.33
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,429.17
Details

MCTS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Malignant T Cell Amplified Sequence 1 (MCTS1) Interaction Partners

Human Malignant T Cell Amplified Sequence 1 (MCTS1) interaction partners

  1. DENR (show DENR Proteins) binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1 (show EIF1 Proteins)/eIF2 (show EIF2S1 Proteins)/eIF3 (show EIF3A Proteins) binding, thus operating in post-termination ribosome recycling and translation re-initiation

  2. Hypoxia-induced MCT1 (show CMA1 Proteins) supports glioblastoma glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness

  3. our finding that the expression of MCT1 (show CMA1 Proteins) and MCT4 (show SLC16A4 Proteins) is reduced in mutant IDH1 (show IDH1 Proteins) gliomas highlights the unusual metabolic reprogramming that occurs in mutant IDH1 (show IDH1 Proteins) tumors and has important implications for our understanding of these tumors and their treatment

  4. MCT1 (show CMA1 Proteins) expression, independent of transporter activity, is required for growth factor-induced tumor cell motility.

  5. TOMM20 (show TOMM20 Proteins), MCT1 (show CMA1 Proteins), and MCT4 (show SLC16A4 Proteins) expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of MCT1 (show CMA1 Proteins), while tumor associated macrophages have absent MCT1 (show CMA1 Proteins) expression. Tumor-infiltrating lymphocytes have absent MCT1 (show CMA1 Proteins) expression. Reactive lymph nodes in contrast to cHL (show CHRDL1 Proteins) tumors had low TOMM20 (show TOMM20 Proteins), MCT1 (show CMA1 Proteins), and MCT4 (show SLC16A4 Proteins) expression in lymphocytes and macrophages.

  6. TOMM20 (show TOMM20 Proteins) and MCT1 (show CMA1 Proteins) were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers.

  7. MCT1 (show CMA1 Proteins) inhibitor AZD3965 increased MCT4 (show SLC16A4 Proteins)-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.

  8. Silencing or genetic deletion of MCT1 (show CMA1 Proteins) in vivo inhibited migration, invasion, and spontaneous metastasis.

  9. The reversible H(+)/lactate(-) symporter MCT1 (show CMA1 Proteins) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.

  10. Reinitiation complexes involving initiation factors eIF2D (show EIF2D Proteins), MCT-1 (show CMA1 Proteins), and DENR (show DENR Proteins) controls the translation of a large fraction of mammalian cellular mRNAs.

Pig (Porcine) Malignant T Cell Amplified Sequence 1 (MCTS1) interaction partners

  1. Data suggest that expression of MCT1 in intestinal mucosa can be altered by diet; here, expression of MCT1 is down-regulated in colonic mucosa by high-protein diet and appears to be linked to fermentation of dietary proteins by intestinal microbes.

  2. MCT1-mRNA showed a higher expression in the ileum; feeding inulin-coated butyrate resulted in an increased ileal surface; delivery of butyrate to the colon requires a more resistant inulin-coating.

Malignant T Cell Amplified Sequence 1 (MCTS1) Protein Profile

Protein Summary

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with MCTS1

  • MCTS1, re-initiation and release factor (MCTS1)
  • solute carrier family 16 member 1 (SLC16A1)
  • malignant T cell amplified sequence 1 (Mcts1)
  • MCTS1, re-initiation and release factor (Mcts1)
  • malignant T cell amplified sequence 1 (mcts1)
  • malignant T-cell amplified sequence 1 (mcts1)
  • MCTS1, re-initiation and release factor (mcts1)
  • malignant T-cell amplified sequence 1 S homeolog (mcts1.S)
  • monocarboxylate transporter 1 (MCT1)
  • 1500019M23Rik protein
  • HHF7 protein
  • MCT protein
  • mct-1 protein
  • MCT-1A protein
  • mct1 protein
  • MCTS1 protein
  • MGC89874 protein
  • zgc:56242 protein

Protein level used designations for MCTS1

malignant T cell-amplified sequence 1 , malignant T-cell-amplified sequence 1 , multiple copies T-cell malignancies , MCT 1 , monocarboxylate transporter 1 , solute carrier family 16 (monocarboxylic acid transporters), member 1 , solute carrier family 16 member 1 , solute carrier family 16, member 1 (monocarboxylic acid transporter 1) , multiple copies T-cell malignancies 1 , MCT-1 , malignant T cell amplified sequence 1 , Malignant T cell amplified sequence 1-A , malignant T cell-amplified sequence 1-A , malignant T-cell-amplified sequence 1-A

GENE ID SPECIES
28985 Homo sapiens
6566 Homo sapiens
68995 Mus musculus
302500 Rattus norvegicus
394046 Danio rerio
422363 Gallus gallus
448679 Xenopus (Silurana) tropicalis
465836 Pan troglodytes
481038 Canis lupus familiaris
508412 Bos taurus
696543 Macaca mulatta
100528791 Ictalurus punctatus
503679 Xenopus laevis
780423 Sus scrofa
100714461 Cavia porcellus
100511797 Sus scrofa
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