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The protein encoded by MCTS1 is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Additionally we are shipping Malignant T Cell Amplified Sequence 1 Antibodies (86) and Malignant T Cell Amplified Sequence 1 Kits (9) and many more products for this protein.
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Hypoxia-induced MCT1 (show CMA1 Proteins) supports glioblastoma glycolytic phenotype, being responsible for lactate efflux and an important mediator of cell survival and aggressiveness
our finding that the expression of MCT1 (show CMA1 Proteins) and MCT4 (show SLC16A4 Proteins) is reduced in mutant IDH1 (show IDH1 Proteins) gliomas highlights the unusual metabolic reprogramming that occurs in mutant IDH1 (show IDH1 Proteins) tumors and has important implications for our understanding of these tumors and their treatment
DENR (show DENR Proteins) binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1 (show EIF1 Proteins)/eIF2 (show EIF2S1 Proteins)/eIF3 (show EIF3A Proteins) binding, thus operating in post-termination ribosome recycling and translation re-initiation
MCT1 (show CMA1 Proteins) expression, independent of transporter activity, is required for growth factor-induced tumor cell motility.
TOMM20 (show TOMM20 Proteins), MCT1 (show CMA1 Proteins), and MCT4 (show SLC16A4 Proteins) expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of MCT1 (show CMA1 Proteins), while tumor associated macrophages have absent MCT1 (show CMA1 Proteins) expression. Tumor-infiltrating lymphocytes have absent MCT1 (show CMA1 Proteins) expression. Reactive lymph nodes in contrast to cHL (show CHRDL1 Proteins) tumors had low TOMM20 (show TOMM20 Proteins), MCT1 (show CMA1 Proteins), and MCT4 (show SLC16A4 Proteins) expression in lymphocytes and macrophages.
TOMM20 (show TOMM20 Proteins) and MCT1 (show CMA1 Proteins) were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers.
MCT1 (show CMA1 Proteins) inhibitor AZD3965 increased MCT4 (show SLC16A4 Proteins)-dependent accumulation of intracellular lactate, inhibiting monocarboxylate influx and efflux.
Silencing or genetic deletion of MCT1 (show CMA1 Proteins) in vivo inhibited migration, invasion, and spontaneous metastasis.
The reversible H(+)/lactate(-) symporter MCT1 (show CMA1 Proteins) cotransports lactate and proton, leading to the net extrusion of lactic acid in glycolytic tumors. A model of its role in pH control in tumor cells is described. Review.
Reinitiation complexes involving initiation factors eIF2D (show EIF2D Proteins), MCT-1 (show CMA1 Proteins), and DENR (show DENR Proteins) controls the translation of a large fraction of mammalian cellular mRNAs.
Data indicate that monocarboxylate transporters (MCTs1-4) were all found to be expressed in brains of embryos, and were localized in both neurons and astrocyte.
This study confirmed age-dependent changes of MCT1 expression in the rumen epithelium of newborn calves and showed that its expression might be affected by liquid feed type.
These findings show that MCT 1 increases with the development of rumen function and also in adult animals MCT 1 may change with the feeding.
The expression and distribution of monocarboxylate transporter 1 along the gastrointestinal tract of calves suggest it may play a role in transport of short chain fatty acids and their metabolites.
The results show that monocarboxylate transporter 1 (MCT1) is a major route for short chain fatty acids (SCFA) efflux across the basolateral membrane of bovine large intestine and that it could play a role in the regulation of intracellular pH.
Data suggest that expression of MCT1 in intestinal mucosa can be altered by diet; here, expression of MCT1 is down-regulated in colonic mucosa by high-protein diet and appears to be linked to fermentation of dietary proteins by intestinal microbes.
MCT1-mRNA showed a higher expression in the ileum; feeding inulin-coated butyrate resulted in an increased ileal surface; delivery of butyrate to the colon requires a more resistant inulin-coating.
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.
malignant T cell-amplified sequence 1
, malignant T-cell-amplified sequence 1
, multiple copies T-cell malignancies
, multiple copies T-cell malignancies 1
, malignant T cell amplified sequence 1
, Malignant T cell amplified sequence 1-A
, malignant T cell-amplified sequence 1-A
, malignant T-cell-amplified sequence 1-A