MCTS1 Protein (AA 1-181, full length) (His-SUMO Tag)

Catalog No. ABIN5711965

Product Details

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Protein Type: Recombinant

Protein Characteristics: full length, AA 1-181

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This MCTS1 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV KIVRCHEHIE ILTVNGELLF FRQREGPFYP TLRLLHKYPF ILPHQQVDKG AIKFVLSGAN IMCPGLTSPG AKLYPAAVDT IVAIMAEGKQ HALCVGVMKM SAEDIEKVNK GIGIENIHYL NDGLWHMKTY K

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Alternative Name: MCTS1 (MCTS1 Products)

Synonyms: MCT-1 Protein, MCT1 Protein, MCT1a Protein, cb517 Protein, zgc:55682 Protein, 1500019M23Rik Protein, zgc:56242 Protein, mcts1 Protein, MGC89874 Protein, MCTS1 Protein, MCT-1A Protein, mct-1 Protein, mct1 Protein, MCT-1B Protein, mcts1-a Protein, mcts1-b Protein, MCTS1, re-initiation and release factor Protein, solute carrier family 16 (monocarboxylate transporter), member 1b Protein, malignant T cell amplified sequence 1 Protein, malignant T-cell amplified sequence 1 Protein, solute carrier family 16 member 1 Protein, malignant T-cell amplified sequence 1 S homeolog Protein, monocarboxylate transporter 1 Protein, malignant T-cell amplified sequence 1 L homeolog Protein, MCTS1 Protein, slc16a1b Protein, Mcts1 Protein, mcts1 Protein, SLC16A1 Protein, mcts1.S Protein, MCT1 Protein, mcts1.L Protein

Background: Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels rains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits

Molecular Weight: 36.54 kDa

UniProt: Q9ULC4