anti-Mannose Receptor, C Type 2 (MRC2) Antibodies

MRC2 encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. Additionally we are shipping MRC2 Kits (31) and MRC2 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MRC2 498011 Q4TU93
MRC2 9902 Q9UBG0
MRC2 17534 Q64449
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Top anti-MRC2 Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Western blot analysis in NCI-H460 cell line lysates (35ug/lane) using CD280 / MRC2 Antibody . This demonstrates this antibody detected the MRC2 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis on 293 cell lysate using MRC2 Antibody,The lane on the left is treated with the antigen-specific peptide. ABIN6266864 at 1/100 staining human lymph node tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from 293 cells, using MRC2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using MRC2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Mrc2 Antibody [NBP1-85768] - Staining of human small intestine shows moderate cytoplasmic positivity in glandular cells. Immunohistochemistry-Paraffin: Mrc2 Antibody  - Staining of human liver shows low expression as expected. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse Brain, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of MRC2 using HeLa whole  lysates. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated WB MRC2 Antibody (Center)  western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MRC2 antibody detected the MRC2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Human 293T cell lysate; Primary Ab: 2µg/ml Rabbit Anti-Human MRC2 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant protein. 100 μg Log in to see 13 to 16 Days
$316.00
Details

More Antibodies against MRC2 Interaction Partners

Cow (Bovine) Mannose Receptor, C Type 2 (MRC2) interaction partners

  1. A second loss-of-function mutation in the bovine mannose receptor C (MRC2) gene causes illegitimate receptor oligomerization, which is predicted to impair function of the MRC2 encoded protein, Endo180.

  2. The positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked Tail Syndrome in cattle, isdescribed.

Human Mannose Receptor, C Type 2 (MRC2) interaction partners

  1. Endo180 knockdown in pancreatic stellate cells (PSCs) attenuated the invasive abilities of PSCs and co-cultured pancreatic cancer cells, and decreased the expression level of phosphorylated myosin light chain 2 (MLC2).

  2. results provide a molecular mechanism to support the structural flexibility of uPARAP, and shed light on the structural flexibility of other members of the MR family

  3. A model of the ligand-binding region of uPARAP was obtained by molecular replacement.

  4. The positive correlation between suPLAUR expression and body mass index, suggests that leukocyte recruitment in obese tissue may be regulated, at least in part, through the splicing of the PLAUR transcript.

  5. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma

  6. Study identifies the interaction between lectin domain in Endo180 and CD147 as an Epithelial-to-mesenchymal transition suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates.

  7. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.

  8. MRC2 is downregulated by UVA irradiation and reduces collagen internalization; this can be recovered by all-trans retinoic acid

  9. Our findings correlate for the first time impaired collagen uptake via Endo180 with the pericellular accumulation of collagen fragments during photoaging.

  10. TGFbeta1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis.

  11. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.

  12. Our present study suggests that uPARAP may be involved in glioma cell invasiveness through actin cytoskeletal rearrangement

  13. fibrillar collagen deposition and the collagen internalization receptor endo180 have roles in glioma invasion

  14. Endo180 is a novel regulator of membrane-bound matrix metalloproteinase (MT1-MMP) activity, MT1-MMP-dependent MMP-2 activation and urokinase plasminogen activator (uPA) activity.

  15. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor

  16. Endo180 was found to be distinct within the mannose receptor family in that the tyrosine-based motif is not required for efficient delivery to and recycling from early endosomes

  17. Mannose receptor activity is up-regulated by surfactant protein A on monocyte-derived macrophages.

  18. characterization of the monosaccharide binding sites

  19. Approximately 60% of the initial association of HIV with macrophages that lack expression of DC-SIGN (a dendritic cell-specific ICAM-3 receptor/HIV-1-binding protein) is mediated by the macrophage mannose receptor.

  20. Results suggest that Endo180 is a crucial link between urokinase-type plasminogen activator and its receptor and setting of the internal cellular compass.

Mouse (Murine) Mannose Receptor, C Type 2 (MRC2) interaction partners

  1. uPARAP controlVEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.

  2. Findings show that under in vivo conditions, uPARAP does not play a role in the phagocytic uptake of collagen fibrils by fibroblasts.

  3. Our findings identify sarcoma cell-resident uPARAP/Endo180 as a central player in the bone degeneration of advanced osteosarcoma

  4. AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed prostate epithelial cells via Endo180 pathway linked to cancer progression.

  5. uPARAP function in cutaneous wound repair

  6. Both uPARAP and MMP-2 take part in matrix turnover processes important for bone growth.

  7. Genetic ablation of the Mrc2 impaired the intracellular collagen degradation pathway.

  8. This function of uPARAP/Endo180 defines a novel role of intracellular collagen turnover in fibrosis protection.

  9. uPARAP is highly expressed in the murine lung, and loss of uPARAP leads to differences in lung mechanics, lung permeability, and collagen content after injury

  10. data establish an important fibrosis-attenuating role for Mrc2-expressing renal interstitial cells and suggest the involvement of a lysosomal collagen turnover pathway

  11. A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uparap/ENDO180.

  12. targeted deletion of Endo180 exons 2-6 results in cells that have a defect in collagen binding and internalization and an impaired migratory phenotype

  13. Deletion of uPARAP/Endo180 impaired collagen turnover critical to tumor expansion, as evidenced by abrogation of collagen uptake, tumor fibrosis, and blunted tumor growth. uPARAP/Endo180 mediates collagen turnover in a pathophysiological context.

  14. The mannose receptor is the main candidate for being the endocytic denatured collagen receptor on liver sinusoidal endothelial cells

  15. fibroblast-mediated collagen degradation proceeds preferentially as a sequential mechanism in which extracellular collagenolysis is followed by uPARAP/Endo180-mediated endocytosis of large collagen fragments.

  16. we demonstrate extensive uPARAP expression in the mesenchyme throughout murine lung development.

MRC2 Antigen Profile

Protein Summary

This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease.

Gene names and symbols associated with MRC2

  • mannose receptor C type 2 (MRC2) antibody
  • mannose receptor, C type 2 (mrc2) antibody
  • mannose receptor C type 2 (mrc2) antibody
  • mannose receptor, C type 2 (Mrc2) antibody
  • CD280 antibody
  • CLEC13E antibody
  • ENDO180 antibody
  • mKIAA0709 antibody
  • MRC2 antibody
  • uPARAP antibody

Protein level used designations for MRC2

mannose receptor, C type 2 , C-type mannose receptor 2 , C-type mannose receptor 2-like , collagen-binding factor Endo180 , endocytic receptor 180 , macrophage mannose receptor 2 , C-type lectin domain family 13 member E , UPAR-associated protein , endocytic receptor (macrophage mannose receptor family) , urokinase-type plasminogen activator receptor-associated protein , lectin lambda , novel lectin

GENE ID SPECIES
454788 Pan troglodytes
529049 Bos taurus
100004793 Danio rerio
100036697 Xenopus (Silurana) tropicalis
100406333 Callithrix jacchus
100541638 Meleagris gallopavo
498011 Rattus norvegicus
9902 Homo sapiens
17534 Mus musculus
100688560 Canis lupus familiaris
100516106 Sus scrofa
419950 Gallus gallus
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