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Acts as a transcriptional coactivator for NOTCH proteins. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal MAML3 Primary Antibody for ICC, IF - ABIN151567
Köchert, Ullrich, Kreher, Aster, Kitagawa, Jöhrens, Anagnostopoulos, Jundt, Lamprecht, Zimber-Strobl, Stein, Janz, Dörken, Mathas: High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas. in Oncogene 2011
Show all 2 Pubmed References
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
RBPJ and MAML3 could be new therapeutic targets for SCLC.
PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2.
These findings indicate that the miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical role in GC metastasis.
Results show that overexpression of MAML3 confers resistance to retinoic acid in multiple neuroblastoma cell lines.
These results suggest that PSK suppresses Hedgehog signaling through down-regulation of MAML3 and RBPJ transcription under hypoxia, inhibiting the induction of a malignant phenotype in pancreatic cancer. Our results may lead to development of new treatments for refractory pancreatic cancer using PSK as a Hedgehog inhibitor
The present study further expands the genetic spectrum of small blue round cell tumors, with 2 novel fusions, BCOR-MAML3 and ZC3H7B-BCOR, identified
Suggest that hypoxia promotes SMO transcription through upregulation of MAML3 and RBPJ to induce proliferation, invasiveness and tumorigenesis in pancreatic cancer.
Identification of new human proteins defines a family that consists of positive regulators for notch signaling
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
, mastermind-like 3
, glutamine repeat protein 1
, mastermind-like protein 3
, CAG repeat containing (glia-derived nexin I alpha)
, CAG repeat domain
, expanded repeat domain, CAG/CTG 3
, polyglutamine rich
, trinucleotide repeat containing 3
, mastermind-like protein 3-like