anti-Matrix Gla Protein (MGP) Antibodies

Human Matrix Gla Protein (MGP) interaction partners

1. This study concluded that diabetes coexisting with renal disease leads to extreme vascular calcification expressed by elevated MGP levels, resulting in higher frequency of cardiovascular disease in comparison to CKD patients without diabetes.

2. Increased desphospho-uncarboxylated matrix Gla protein, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

3. Our results indicate that the association between the matrix Gla protein variant and increased risk for hand Osteoarthritis is caused by a lower expression of matrix Gla protein, which may increase the burden of hand Osteoarthritis by decreased inhibition of cartilage calcification.

4. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.

5. MGP is significantly repressed by miR (show MLXIP Antibodies)-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness.

6. ectopic expression of Mgp in murine and human osteosarcoma cells led to a marked increase in lung metastasis. Abrogation of Mgp prevented lung metastatic activity, an effect that was rescued by forced expression. Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo

7. MGP rs4236 [A/G] gene polymorphism was not to be associated with subgingival dental calculus. Also, that GCF (show GUCY2F Antibodies) MGP levels were detected higher in patients with subgingival dental calculus than those without subgingival dental calculus independently of polymorphism, may be the effect of adaptive mechanism to inhibit calculus formation.

8. The substitution of threonine by alanine due to MGP exon 4 Thr83Ala polymorphism is related to a decrease in the likelihood of arterial calcification in female persons in the Ukrainian population

9. Correlations of plasma desphosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) with vascular calcification and vascular stiffness in chronic kidney disease. Plasma dp-ucMGP was positively associated with vascular calcification and might be utilized as an early marker for vascular calcification in CKD patients.

10. It is assumed that Lp-PLA2 (show Lp-PLA2 Antibodies) is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 (show Lp-PLA2 Antibodies) itself.

Mouse (Murine) Matrix Gla Protein (MGP) interaction partners

1. We propose MGP as a strong candidate for the regulation of stiffness in glaucoma. MGP further illustrates the presence of a common function affecting key glaucomatous parameters in the front and back of the eye, and thus offers the possibility for a sole therapeutic target for the disease.

2. the nasal septum to be abnormally mineralized and shortened in Mgp(-/-) mice. Transgenic restoration of Mgp expression in chondrocytes fully corrected the craniofacial anomalies caused by MGP deficiency, suggesting a local role for MGP in the developing nasal septum.

3. loss of MGP causes dysregulation of early endothelial differentiation.

4. Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 (show ACVRL1 Antibodies) deficiency.

5. expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels.

6. Elastin (show ELN Antibodies) haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.

7. The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice.

8. Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (show TGM2 Antibodies) and elastin (show ELN Antibodies) fragmentation associated with induction of adipsin (show CFD Antibodies).

9. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

10. Mgp gene deletion may have a role in arteriovenous malformations

Cow (Bovine) Matrix Gla Protein (MGP) interaction partners

1. Selective CaSR (show CASR Antibodies) activation, either by extracellular calcium or AMG (show AMELX Antibodies) 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.

2. the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2 (show BMP2 Antibodies)

3. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF (show VEGFA Antibodies) expression

4. MGP has a novel binding activity for vitronectin (show VTN Antibodies)

5. Heat shock protein 70 (show HSP70 Antibodies) enhances vascular bone morphogenetic protein-4 (show BMP4 Antibodies) signaling by binding matrix Gla protein.

Xenopus laevis Matrix Gla Protein (MGP) interaction partners

1. Usefulnees of nonmammalian model systems to elucidate the complex regulation of MGP gene transcription.

2. These data also indicate that MGP is under dual regulation by runx2 (show RUNX2 Antibodies) through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Matrix Gla Protein (MGP) interaction partners

1. High DNA methylation (show HELLS Antibodies) resulting in the down regulation of matrix Gla protein is associated with osteochondrosis.

Zebrafish Matrix Gla Protein (MGP) interaction partners

1. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

2. In contrast with results obtained for previously studied marine fishes, in zebrafish and Senegal sole Mgp accumulates in both calcified tissues and non-mieralized vessel walls of the vascular system.