Matrix Gla Protein (MGP) ELISA Kits

Human Matrix Gla Protein (MGP) interaction partners

1. the MGP gene rs1800801 polymorphism is significantly associated with vascular calcification and atherosclerotic disease, especially in the Caucasian population.

2. This study observed increased expression of MGP in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines at both mRNA and protein level.

3. Dp-ucMGP was high preoperatively, and further increased postoperatively in cardiovascular risk patients.

4. Study found an association between diastolic left ventricular function with circulating inactive desphospho-uncarboxylated MGP in two cohorts; undertook histological studies confirming the presence of MGP in the heart and determining its exact localization in healthy and diseased hearts, using conformation-specific MGP antibodies.

5. Studied serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) in patients who were admitted to emergency department with the diagnosis of acute coronary syndrome (ACS) and underwent primary percutaneous coronary intervention. MGP and BMP-4 levels were significantly elevated when compared to subjects with normal coronary arteries.

6. genetic association studies in population in Greece: Data suggest that an SNP in promoter region of matrix Gla protein (rs1,800,802; T-138C) is associated with diabetic angiopathy (as indicated by carotid intima media thickness) in patients with type 2 diabetes and diabetic nephropathy.

7. This study concluded that diabetes coexisting with renal disease leads to extreme vascular calcification expressed by elevated MGP levels, resulting in higher frequency of cardiovascular disease in comparison to CKD patients without diabetes.

8. Increased desphospho-uncarboxylated matrix Gla protein, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

9. Our results indicate that the association between the matrix Gla protein variant and increased risk for hand Osteoarthritis is caused by a lower expression of matrix Gla protein, which may increase the burden of hand Osteoarthritis by decreased inhibition of cartilage calcification.

10. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.

11. MGP is significantly repressed by miR-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness.

12. ectopic expression of Mgp in murine and human osteosarcoma cells led to a marked increase in lung metastasis. Abrogation of Mgp prevented lung metastatic activity, an effect that was rescued by forced expression. Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo

13. MGP rs4236 [A/G] gene polymorphism was not to be associated with subgingival dental calculus. Also, that GCF MGP levels were detected higher in patients with subgingival dental calculus than those without subgingival dental calculus independently of polymorphism, may be the effect of adaptive mechanism to inhibit calculus formation.

14. The substitution of threonine by alanine due to MGP exon 4 Thr83Ala polymorphism is related to a decrease in the likelihood of arterial calcification in female persons in the Ukrainian population

15. Correlations of plasma desphosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) with vascular calcification and vascular stiffness in chronic kidney disease. Plasma dp-ucMGP was positively associated with vascular calcification and might be utilized as an early marker for vascular calcification in CKD patients.

16. circulating dp-ucMGP and dp-cMGP may have a role in increasing risk of all-cause and cardiovascular mortality

17. It is assumed that Lp-PLA2 is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 itself.

18. Data shoed increased GAS6 and decreased MGP levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification.

19. Altering NOTCH1 levels affected MGP mRNA and protein.

20. Uncarboxylated MGP in synovial fluid might serve as a novel biomarker for assessing knee osteoarthritis progression.

Mouse (Murine) Matrix Gla Protein (MGP) interaction partners

1. We propose MGP as a strong candidate for the regulation of stiffness in glaucoma. MGP further illustrates the presence of a common function affecting key glaucomatous parameters in the front and back of the eye, and thus offers the possibility for a sole therapeutic target for the disease.

2. the nasal septum to be abnormally mineralized and shortened in Mgp(-/-) mice. Transgenic restoration of Mgp expression in chondrocytes fully corrected the craniofacial anomalies caused by MGP deficiency, suggesting a local role for MGP in the developing nasal septum.

3. loss of MGP causes dysregulation of early endothelial differentiation.

4. Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency.

5. expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels.

6. Matrix Gla's restricted expression to glaucoma-associated tissues from anterior and posterior segments suggests its involvement in the development of the disease.

7. Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.

8. The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice.

9. Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin.

10. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

11. Mgp gene deletion may have a role in arteriovenous malformations

12. role in vascular calcification in vivo

13. MGP is a known inhibitor of mineralization, and mice deficient in Mgp show severe vascular calcification and premature bone mineralization.

14. Inorganic phosphate(Pi) regulates MGP expression in growth plate chondrocytes, thereby suggesting a key role for Pi and ERK1/2 in the regulation of bone formation.

15. PTH regulates MGP via both PKA- and ERK-dependent pathways.

16. Matrix GLA protein is an inhibitory morphogen in pulmonary vascular development

17. MGP in Abcc6-/- mice is largely in inactive form and is unable to prevent the unwanted mineralization of connective tissues in PXE.

18. Extensive hypomineralization was observed in dentin and alveolar bone from transgenic mice expressing matrix Gla protein when compared with that in wild-type tissues. Mineralization was virtually absent in tooth root dentin and cellular cementum.

19. Oral anticoagulant treatment decreased local expression of MGP.

20. Inorganic phosphate regulates MGP expression in osteoblasts through the ERK1/2-Fra-1 pathway.

Cow (Bovine) Matrix Gla Protein (MGP) interaction partners

1. Selective CaSR activation, either by extracellular calcium or AMG 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.

2. the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2

3. MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression

4. MGP has a novel binding activity for vitronectin

5. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.

Xenopus laevis Matrix Gla Protein (MGP) interaction partners

1. Usefulnees of nonmammalian model systems to elucidate the complex regulation of MGP gene transcription.

2. These data also indicate that MGP is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Matrix Gla Protein (MGP) interaction partners

1. High DNA methylation resulting in the down regulation of matrix Gla protein is associated with osteochondrosis.

Zebrafish Matrix Gla Protein (MGP) interaction partners

1. MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways

2. In contrast with results obtained for previously studied marine fishes, in zebrafish and Senegal sole Mgp accumulates in both calcified tissues and non-mieralized vessel walls of the vascular system.