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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP12 Antibodies (196) and MMP12 Proteins (31) and many more products for this protein.
Showing 10 out of 67 products:
Demedts, Morel-Montero, Lebecque, Pacheco, Cataldo, Joos, Pauwels, Brusselle: Elevated MMP-12 protein levels in induced sputum from patients with COPD. in Thorax 2006
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Margheri, Serratì, Lapucci, Chillà, Bazzichi, Bombardieri, Kahaleh, Calorini, Bianchini, Fibbi, Del Rosso: Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12. in Arthritis and rheumatism 2010
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Human MMP12 ELISA Kit for Sandwich ELISA - ABIN457032
Proietta, Tritapepe, Cifani, Ferri, Taurino, Del Porto: MMP-12 as a new marker of Stanford-A acute aortic dissection. in Annals of medicine 2014
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Mouse (Murine) MMP12 ELISA Kit for Sandwich ELISA - ABIN415783
Lenglet, Montecucco, Mach, Schaller, Gasche, Copin: Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke. in Thrombosis and haemostasis 2014
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Mouse (Murine) MMP12 ELISA Kit for Sandwich ELISA - ABIN1672891
Houghton, Hartzell, Robbins, Gomis-Rüth, Shapiro: Macrophage elastase kills bacteria within murine macrophages. in Nature 2009
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Human MMP12 ELISA Kit for Sandwich ELISA - ABIN414972
Toumpanakis, Noussia, Sigala, Litsiou, Loverdos, Zacharatos, Karavana, Michailidou, Magkou, Zhou, Theocharis, Vassilakopoulos: Inspiratory resistive breathing induces MMP-9 and MMP-12 expression in the lung. in American journal of physiology. Lung cellular and molecular physiology 2015
Rat (Rattus) MMP12 ELISA Kit for Sandwich ELISA - ABIN416465
Krarup, Eld, Heinemeier, Jorgensen, Hansen, gren: Expression and inhibition of matrix metalloproteinase (MMP)-8, MMP-9 and MMP-12 in early colonic anastomotic repair. in International journal of colorectal disease 2013
findings define a novel physiological function of Shp2 (show PTPN11 ELISA Kits) in TGF-beta1 (show TGFB1 ELISA Kits)/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder.
Mmp12 is expressed early following corneal epithelial injury with highest expression levels at 8 h after injury and lower expression levels at 4 and 8 days after injury. We investigated whether MMP12 has an effect on the rate of epithelial repair and cell migration using in vivo and in vitro scratch assays performed on WT and Mmp12(-/-) mice
MMP-12 produced by macrophages infiltrating into glomeruli contributed to the degradation of collagen type IV (show COL4 ELISA Kits) and fibronectin (show FN1 ELISA Kits).
MMP12 causes arterial stiffening in mice and suggest that it functions similarly in humans.
These results suggest that MMP-12 production during emphysema exacerbation results in increased mortality and disease progression.
study found significant increases of MMP-3 (show MMP3 ELISA Kits) and MMP-12 mRNA levels and MMP12 zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection
The results suggest that pulmonary C fiber involvement in long-term airway inflammation and airway hyperresponsiveness occurred at least partially via modulating MMP-12, and the activation of PAR2 (show F2RL1 ELISA Kits) might be related to MMP-12 production.
MMP-12 up-regulation mediated by SARM-TRIF (show RNF138 ELISA Kits) signaling pathway contributes to IFN-gamma (show IFNG ELISA Kits)-independent airway inflammation and AHR (show AHR ELISA Kits) post RSV infection in nude mice.
MMP-12 and MMP-13 (show MMP13 ELISA Kits) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Post-MI, MMP-12i impaired CD44 (show CD44 ELISA Kits)-HA interactions to suppress neutrophil apoptosis and prolong inflammation, which worsened LV function.
M4 macrophages are a possible source for HDAC9 (show HDAC9 ELISA Kits) and MMP12 expression in advanced human carotid plaques.
MMP12 levels were increased in gingival tissue of periodontitis patients. MMP12-producing monocyte-derived cells also had reduced CD200R (show CD200R1 ELISA Kits) surface levels. MMP12 production by these cells was induced by CSF2 (show CSF2 ELISA Kits), and treatment with a CD200R (show CD200R1 ELISA Kits) ligand reduced CSF2 (show CSF2 ELISA Kits)-induced MMP12 production. This novel association of the CD200 (show CD200 ELISA Kits)/CD200R (show CD200R1 ELISA Kits) pathway with MMP12 production by monocyte-derived cells may play a key role in PD progression.
G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD (show ARCN1 ELISA Kits) in Bulgarian population
Data indicate that MMP1 (show MMP1 ELISA Kits), MMP12 and PPARG (show PPARG ELISA Kits) and hsa (show CD24 ELISA Kits)-miR (show MLXIP ELISA Kits)-31-5p, hsa (show CD24 ELISA Kits)-miR (show MLXIP ELISA Kits)-224-5p, and hsa (show CD24 ELISA Kits)-miR (show MLXIP ELISA Kits)-223-3p were able to distinguish tumors from NPT with high sensitivity and specificity.
Increased levels of MMP1 (show MMP1 ELISA Kits) and MMP12 on tumor-associated macrophages in the peripheral areas of dermatofibrosarcoma protuberance might contribute to local invasion
Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3 (show MMP3 ELISA Kits), MMP9 (show MMP9 ELISA Kits), MMP12, and MMP13 (show MMP13 ELISA Kits) were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B (show IL1B ELISA Kits)) expression.
We also found that MMP12 facilitated type I collagen induced platelet aggregation, adhesion and alpha granule secretion. Similarly, one short peptide, WYKG, facilitated type I collagen induced platelet alpha granule secretion. We conclude that platelet express MMP12 may facilitate platelet activation through shedding of CEACAM1 (show CEACAM1 ELISA Kits).
There were no statistically significant differences in the distribution of MMP7 (show MMP7 ELISA Kits) -181 A/G and MMP12 -82 A/G genotype, allele, or haplotype frequencies between IRSA patients and controls, as well as patients' primary and secondary idiopathic recurrent spontaneous abortion
To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 and MMP-13 (show MMP13 ELISA Kits) expression, which is further controlled by NF-kappaB (show NFKB1 ELISA Kits) signaling.
This study demonstrated that the MMP-12 levels was significantly higher in patients with atheromatous plaques than in those without plaques.
Gene expression profiling performed on tissues obtained from pulmonary sarcoidosis patients identified MMP12 as a potential pathogenic mediator of lung damage and/or remodeling and may serve as a marker for this disease.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metallopeptidase 12 (macrophage elastase)
, matrix metalloproteinase 12
, macrophage elastase
, macrophage metalloelastase
, matrix metalloproteinase-12
, matrix metalloproteinase 12 (macrophage elastase)
, macrophage metalloelastase MMP-12