Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) ELISA Kits

Human Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. MMP-13 plays a critical role in the shedding/cleavage of PD-L1 (show CD274 ELISA Kits) in the human head and neck squamous cell carcinoma.

2. MMP-2 (show MMP2 ELISA Kits) promoted and MMP-13 disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR (show EGFR ELISA Kits) signal activation.

3. Data suggest that matrix metalloproteinase 13 (MMP-13) and its regulatory networks are suitable targets for the development of effective early treatment strategies for osteoarthritis (OA).

4. our results indicated that IL-1beta (show IL1B ELISA Kits) treatment resulted in a significant increase in expression of the transcriptional factor interferon regulatory factor-1 (IRF-1 (show IRF1 ELISA Kits)) at both the mRNA and protein levels, which was significantly ameliorated by treatment with Nebivolol. The combination of these findings suggests that Nebivolol can potentially be applied in human osteoarthritis treatment

5. High Expressions of MMP-13 is associated with degenerative knee osteoarthritis.

6. One important finding of the present study was that MMP-3 (show MMP3 ELISA Kits) appears to be involved solely in early-onset preeclampsia, but not in late-onset preeclampsia. Higher levels of MMP-2 (show MMP2 ELISA Kits) and MMP-13 and lower levels of MMP-9 (show MMP9 ELISA Kits) seem to be related to both early- and late-onset severe preeclampsia.

7. Transfection of cells with either miR (show MLXIP ELISA Kits)-100 or miR (show MLXIP ELISA Kits)-125b negated the induction of MMP13 release. Additionally, AR activation induced a morphological alteration of MDA-MB-453 cells, which was blocked by miR (show MLXIP ELISA Kits)-125b only.

8. ATM (show ATM ELISA Kits) could be activated by lung cancer-associated TNF-alpha (show TNF ELISA Kits), up-regulate MMP-13 expression and thereby augment tumor metastasis

9. The Sp1 (show PSG1 ELISA Kits)-mediaded allelic regulation of MMP13 expression by an esophageal squamous cell carcinoma susceptibility SNP rs2252070 has been demonstrated.

10. MMP-13 IRS (show IARS ELISA Kits) represents a suitable method to assess pathologic grade of precancerous and cancerous colorectal lesions. MMP-13 has been identified as an excellent marker of high grade IEN and CRC (show CALR ELISA Kits), and may thus be applied for prognostic stratification.

Mouse (Murine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. MMP-2 (show MMP2 ELISA Kits) promoted and MMP-13 disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR (show EGFR ELISA Kits) signal activation.

2. The data demonstrate that MMP13 and CTGF (show CTGF ELISA Kits) play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.

3. CXCL10 (show CXCL10 ELISA Kits) has strong inhibitory effects on neovascularization, whereas MMP13 is required for neovascularization in C. albicans-infected corneas.

4. that MMP-13 is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

5. the phenotype seen in the Hdac4 (show HDAC5 ELISA Kits)(-/-) mice is partially derived from elevation in MMP-13 and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

6. MEF2C (show MEF2C ELISA Kits) is necessary for Mmp13 gene expression at the transcriptional level and participates in PTH (show PTH ELISA Kits)-stimulated Mmp13 gene expression by increased binding to c-FOS at the AP-1 (show JUN ELISA Kits) site in the Mmp13 promoter.

7. data reveal a novel involvement of MMP-13 in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (show CCL1 ELISA Kits) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (show CD8A ELISA Kits)(+) T-cell response in vitro; MMP-13 might be a promising target for therapeutic intervention in inflammatory diseases

8. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (show DDR2 ELISA Kits)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (show DDR2 ELISA Kits) and matrix metalloproteinase 13.

9. Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 ELISA Kits) with an inducible Col2a1 (show COL2A1 ELISA Kits)-Cre caused premature production of pErk1/2 and Mmp13 in the growth plate.

10. Mmp13 is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH ELISA Kits), and Osterix (show SP7 ELISA Kits) through distal enhancers.

Cow (Bovine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. p38 (show MAPK14 ELISA Kits) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

2. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

3. MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (show FMOD ELISA Kits) fragments

4. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (show MMP1 ELISA Kits) and MMP-13 (follicular apex (show APEX1 ELISA Kits) vs. base) for the preovulatory collagenolysis required for follicle rupture

5. involvement of p38 MAP kinase (show MAPK14 ELISA Kits) in the hyaluronan oligosaccharide induction of MMP-13

6. MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (show COL2A1 ELISA Kits)

7. At high but naturally occurring concentrations the collagen peptide CB12-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (show COL2A1 ELISA Kits) by collagenase in the mid zone and also in the superficial zone.

Xenopus laevis Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. XCL3 and XCL4 can be differentially induced by prolactin (show PRL ELISA Kits) and thyroid hormone (show PTH ELISA Kits)(3)

Zebrafish Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (show MMP9 ELISA Kits) and Mmp13.

2. Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.

3. JNK (show MAPK8 ELISA Kits)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Rabbit Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. These results suggest that PEP-1-SIRT2 (show SIRT2 ELISA Kits) promotes matrix metalloproteinases-induced dedifferentiation via ERK (show MAPK1 ELISA Kits) signaling in articular chondrocytes.

2. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (show MMP3 ELISA Kits) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

3. Leptin (show LEP ELISA Kits) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (show TNF ELISA Kits) in rabbit articular chondrocytes in vitro.

Horse (Equine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.

Pig (Porcine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) interaction partners

1. TNF-alpha (show TNF ELISA Kits) induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.