Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Proteins (MMP3)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antibodies (366) and Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (164) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MMP3 4314 P08254
MMP3 17392 P28862
MMP3 171045  
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Top Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Proteins at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
HEK-293 Cells Mouse Un-conjugated   10 μg Log in to see 10 to 12 Days
$226.22
Details
HEK-293 Cells Human Un-conjugated   10 μg Log in to see 10 to 12 Days
$226.22
Details
Escherichia coli (E. coli) Human Un-conjugated 10 μg Log in to see 6 to 7 Days
$482.80
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$717.00
Details
Human Cells Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Escherichia coli (E. coli) Human Un-conjugated Validation with Western Blot 10 μg Log in to see 8 to 11 Days
$218.90
Details
Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$733.00
Details

MMP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
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Mouse (Murine) ,
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Rat (Rattus) ,
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More Proteins for Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) Interaction Partners

Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. study to explore the relationship between 2 polymorphisms (MMP-1 (show MMP1 Proteins)-755 T/G [rs498186] and MMP-3 A/C [rs632478]) and disc degeneration; a significant association was found between the MMP-3 polymorphism and disc degeneration; the homozygote CC was associated with an increased risk of disc degeneration compared with the AA genotype

  2. Higher serum MMP-3 levels in knee osteoarthritis reflect disease "generalization".

  3. Report a positive correlation between glomerular filtration rate and MMP-3 activity in diabetic patients.

  4. The maternal and fetal MMP3 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.

  5. 2G allele of MMP-1 (show MMP1 Proteins), C allele of MMP-2 (show MMP2 Proteins) and 5A/6A genotype of MMP-3 are associated with susceptibility and disease progression of type 2 diabetic nephropathy

  6. MMP-1 (show MMP1 Proteins) genotype may accelerate the development of HIV-associated neurocognitive disorder (HAND) whereas MMP3 -1612 5A5A genotype may reduce the risk of pathogenesis of HAND.

  7. Preliminary studies indicate that baseline MMP3 and TIMP3 (show TIMP3 Proteins) concentrations are associated with patient survival and disease-free time

  8. MMP-3 (Lys45Glu) polymorphisms associate with obesity risk and its severity.

  9. Data suggest that serum matrix metalloproteinase-3 (MMP-3) and the 7-joint ultrasound score (US7) scores could both effectively reflect disease activity and therapeutic responses in patients with moderate to severe rheumatoid arthritis (RA).

  10. results demonstrated that measurement of MMP-3 could become a marker of disease activity in rheumatoid arthritis patients

Mouse (Murine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. Estrogen-related receptor gamma (ERRgamma (show ESRRG Proteins)) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 and MMP13 (show MMP13 Proteins), which are known to play crucial roles in cartilage destruction in osteoarthritis (OA).

  2. MMP3 contributes to the pathogenesis of ARDS by affecting the pulmonary inflammatory response in female mice in relevant models of lung injury.

  3. endogenously secreted chemerin (show RARRES2 Proteins) plays an autocrine/paracrine role in white adipose tissue, identifying chemerin (show RARRES2 Proteins) as a therapeutic target to modulate adipose remodelling.

  4. Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 (show TIMP4 Proteins) may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.

  5. Matrix metalloprotease (show ADAMTS7 Proteins) 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF (show CSF2 Proteins), and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.

  6. These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.

  7. Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) and (C-X-C motif) ligand 1 (CXCL1 (show CXCL1 Proteins)).

  8. Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.

  9. NMP4 (show ZNF384 Proteins) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL (show TNFSF11 Proteins) and MMP-3 mRNA.

  10. MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (show MAPK14 Proteins) activation and proNGF production

Pig (Porcine) Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1 (show TGFB1 Proteins)) and collagen type X alpha I (COL10A1 (show COL10A1 Proteins)) gene polymorphisms with traits related to leg weakness in pigs.

  2. the identification of MMP1 (show MMP1 Proteins) and MMP10 (show MMP10 Proteins) genes in swine is reported.

  3. contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Proteins) barrier in vitro

  4. Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1 (show MMP1 Proteins), MMP-3, and TIMP-1 (show TIMP1 Proteins) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.

Rabbit Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) interaction partners

  1. Compromised autophagy may be related to the osteoarthritis progression; JNK (show MAPK8 Proteins) and p38 (show MAPK14 Proteins) MAPKs up-regulate MMP3 and down-regulate autophagy.

  2. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

  3. Ulinastatin (show AMBP Proteins) effectively inhibited the increased expression of MMP-2 (show MMP2 Proteins), MMP-3, and iNOS (show NOS2 Proteins) in degenerated NP cells induced by IL-1beta (show IL1B Proteins) in vitro.

  4. Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma (show PPARG Proteins) in atherosclerotic rabbits.

Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) (MMP3) Protein Profile

Protein Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Gene names and symbols associated with MMP3

  • matrix metallopeptidase 3 (MMP3)
  • matrix metallopeptidase 3 (Mmp3)
  • matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3)
  • matrix metallopeptidase 3 L homeolog (mmp3.L)
  • chds6 protein
  • mmp-3 protein
  • mmp3 protein
  • MMP10 protein
  • mmp13 protein
  • sl-1 protein
  • SLN-1 protein
  • SLN1 protein
  • stmy protein
  • stmy1 protein
  • STR-1 protein
  • str1 protein

Protein level used designations for MMP3

matrix metalloproteinase 3 (stromelysin 1, progelatinase) , matrix metalloproteinase-3 , proteoglycanase , stromelysin-1 , transin-1 , EMS-2 , MMP-3 , SL-1 , matrix metalloproteinase 3 , progelatinase , stromelysin 1 , PTR1 protein , stromelysin , metalloproteinase 3 receptor , matrix metallopeptidase 3 (stromelysin 1, progelatinase) , matrix metallopeptidase 3 L homeolog , matrix metalloproteinase 13 (collagenase 3)

GENE ID SPECIES
4314 Homo sapiens
17392 Mus musculus
171045 Rattus norvegicus
396769 Sus scrofa
100009111 Oryctolagus cuniculus
100034195 Equus caballus
403445 Canis lupus familiaris
281309 Bos taurus
101118895 Ovis aries
446898 Xenopus laevis
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