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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antibodies (432) and Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (162) and many more products for this protein.
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MMP3 contributes to the pathogenesis of ARDS by affecting the pulmonary inflammatory response in female mice in relevant models of lung injury.
endogenously secreted chemerin (show RARRES2 Proteins) plays an autocrine/paracrine role in white adipose tissue, identifying chemerin (show RARRES2 Proteins) as a therapeutic target to modulate adipose remodelling.
Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 (show TIMP4 Proteins) may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.
Matrix metalloprotease (show ADAMTS7 Proteins) 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF (show CSF2 Proteins), and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.
These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.
Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 (show CPT1B Proteins) and (C-X-C motif) ligand 1 (CXCL1 (show CXCL1 Proteins)).
Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.
NMP4 (show ZNF384 Proteins) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL (show TNFSF11 Proteins) and MMP-3 mRNA.
MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (show MAPK14 Proteins) activation and proNGF production
genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice
studies establish a molecular imaging reporter for diagnosing early-stage EOC. Additional studies are required to confirm the early-stage activity of MMP-3 in EOC and its diagnostic and prognostic significance
among Chinese males, MMP-3 rs650108 and MMP-8 (show MMP8 Proteins) rs2012390 decrease alcohol-induced ONFH risk and MMP-8 (show MMP8 Proteins) rs11225394 increases it.
The present results suggested that Icariin may have a chondroprotective effect, exerted through the inhibition of MMP1 (show MMP1 Proteins), MMP3 and MMP13 (show MMP13 Proteins) via MAPK (show MAPK1 Proteins) pathways. Therefore, Icariin may have potential as a novel therapeutic strategy for the treatment of osteoarthritis.
Report an association between the MMP-3 rs3025058 and subclinical markers of carotid and coronary atherosclerosis at the time of recruitment. MMP-3 rs3025058 on affects carotid artery disease progression in the 3.8-year follow-up in patients with T2DM.
results suggest that MMP1 (show MMP1 Proteins)-1607 1G/2G, MMP3-1171 5A/6A and MMP9 (show MMP9 Proteins)-1562 C/T gene polymorphisms have synergistic effect on breast cancer. The interactions of MMPs clinical risk factors such as lymph node involvement has shown a strong correlation and might influence the 5-years survival rate, suggesting their potential role in the breast carcinogenesis
mRNA levels of HSP family members (HSP70B', HSP72 (show HSPA1A Proteins), HSP40/DNAJ (show DNAJB1 Proteins), and HSP20 (show HSPB6 Proteins)/CRYAB (show CRYAB Proteins)) are upregulated by the intracellular MMP3 overload.
IL-21 (show IL17C Proteins) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 (show MMP1 Proteins) and MMP-3.
The genetic polymorphism of MMP-1 and MMP-3 is associated with rotator cuff tear. Individuals with haplotype 2G/5A were more susceptible to rotator cuff tears in the population studied.
Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10 (show ATG10 Proteins), Wnt5a (show WNT5A Proteins), alpha1 integrin (show ITGA1 Proteins), and matrix metalloproteinase-3 in GS/BMP-4 (show BMP4 Proteins)-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1 (show FGF1 Proteins)/fibroblast growth factor receptor 4 (show FGFR4 Proteins) signaling in the progression of ovarian cancer. the expression level of Snail1 (show SNAI1 Proteins) and MMP3 was reduced, while the expression level of E-cadherin (show CDH1 Proteins) increased
The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1 (show TGFB1 Proteins)) and collagen type X alpha I (COL10A1 (show COL10A1 Proteins)) gene polymorphisms with traits related to leg weakness in pigs.
the identification of MMP1 (show MMP1 Proteins) and MMP10 (show MMP10 Proteins) genes in swine is reported.
contribution of MMPs to the inflammatory breakdown of the blood-CSF (show CSF2 Proteins) barrier in vitro
Results indicate that leukemia inhibitory factor (LIF (show LIF Proteins)) and Oncostatin M (show OSM Proteins) increase the expression of MMP-1 (show MMP1 Proteins), MMP-3, and TIMP-1 (show TIMP1 Proteins) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Proteins) antagonist MH35-BD.
Compromised autophagy may be related to the osteoarthritis progression; JNK (show MAPK8 Proteins) and p38 (show MAPK14 Proteins) MAPKs up-regulate MMP3 and down-regulate autophagy.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Ulinastatin (show AMBP Proteins) effectively inhibited the increased expression of MMP-2 (show MMP2 Proteins), MMP-3, and iNOS (show NOS2 Proteins) in degenerated NP cells induced by IL-1beta (show IL1B Proteins) in vitro.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma (show PPARG Proteins) in atherosclerotic rabbits.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
, matrix metalloproteinase 3
, matrix metalloproteinase-3
, stromelysin 1
, PTR1 protein
, matrix metalloproteinase 3 (stromelysin 1, progelatinase)
, metalloproteinase 3 receptor
, matrix metallopeptidase 3 (stromelysin 1, progelatinase)
, matrix metalloproteinase 10 (stromelysin 2)