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May be involved in early meiosis (By similarity).. Additionally we are shipping MEIOB Antibodies (6) and many more products for this protein.
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MEIOB interacts with RPA and SPATA22.
we propose that RPA (show RPA1 Proteins) and this new single-strand DNA binding protein (show UBE2V1 Proteins) MEIOB, are essential to ensure the proper stabilization of recombinases which is required for successful homology search and meiotic recombination.
MEIOB and SPATA22 form an obligate complex and contain defined interaction domains. A single residue D383 in MEIOB is indispensable for the MEIOB-SPATA22 interaction. The MEIOB/SPATA22 complex interacts with the RPA heterotrimeric complex in a collaborative manner.
MEIOB is a meiosis-specific paralogue of RPA1 (show RPA1 Proteins). MEIOB colocalizes with RPA (show RPA1 Proteins) in foci on meiotic chromosomes. MEIOB binds to single-stranded DNA and exhibits 3'-5' exonuclease (show EXOSC10 Proteins) activity. MEIOB forms a complex with RPA (show RPA1 Proteins) and with SPATA22. Chromatin localization and stability of MEIOB depends on SPATA22 and vice versa. MEIOB is essential for meiotic recombination in both sexes.
May be involved in early meiosis (By similarity).
meiosis-specific with OB domain-containing protein
, protein expressed in male leptotene and zygotene spermatocytes 675