anti-Melanoma Cell Adhesion Molecule (MCAM) Antibodies

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Additionally we are shipping MCAM Kits (41) and MCAM Proteins (28) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MCAM 4162 P43121
MCAM 78967 Q9EPF2
MCAM 84004 Q8R2Y2
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Top anti-MCAM Antibodies at antibodies-online.com

Showing 10 out of 653 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse FITC EIA, FACS, IHC (fro)   0.1 mg Log in to see 6 to 8 Days
$555.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- CD146 antibody, Western blotting All lanes: Anti CD146  at 0.5ug/ml Lane 1: A375 Whole Cell Lysate at 40ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: HEPG2 Whole Cell Lysate at 40ug Predicted bind size: 72KD Observed bind size: 100KD Anti- CD146 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: CD146 Antibody [NBP2-15778] - Sample (30 ug of whole cell lysate) A: HCT116 5% SDS PAGE gel, diluted at 1:1000. Immunohistochemistry-Paraffin: CD146 Antibody [NBP2-15778] - Immunohistochemical analysis of paraffin-embedded J5 xenograft, using antibody at 1:500 dilution. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Mouse Un-conjugated FACS, IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Mouse Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$430.10
Details
Human Rabbit Un-conjugated ELISA, ELISA (Detection), FACS, IF, IF/ICC, IHC (p) Flow cytometric analysis of anti-CD146 (10115-R044, 0.5 μg/test) on HeLa cells. HeLa cells were detached using 1X trypsin, washed, then stained with purified rabbit anti-CD146. Second step staining with goat anti-rabbit IgG FC polyclonal antibody. Immunohistochemical staining of formalin fixed, paraffin-embedded human lymphonode showing membrane staining of endothelial cells (red arrow) (5 μg/mL). 100 μg Log in to see 20 to 21 Days
$273.90
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Immunohistochemical staining of formalin fixed, paraffin-embedded human kidney showing membrane staining of endothelial cells (red arrow) (5 μg/mL). Immunohistochemical staining of formalin fixed, paraffin-embedded human lymphonode showing membrane staining of endothelial cells (red arrow), smooth muscle cells (black arrow) (5 μg/mL). 100 μg Log in to see 20 to 21 Days
$273.90
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image CD146 antibody detects CD146 protein by western blot analysis. Whole cell extracts (30 μg) was separated by 7.5 % SDS-PAGE, and blotted with CD146 antibody , diluted by 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human ovarian cancer, using CD146, antibody at 1:500 dilution. 100 μL Log in to see 1 to 2 Days
$358.60
Details

MCAM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MCAM Antibodies

  1. Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896788 : Fujinaga, Baker, Ryan, Markham, Seedorf, Balasubramaniam, Abman: Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants. in American journal of physiology. Lung cellular and molecular physiology 2009 (PubMed)
    Show all 4 Pubmed References

  2. Dog (Canine) Monoclonal MCAM Primary Antibody for IHC (f), ICC - ABIN2749196 : Solovey, Lin, Browne, Choong, Wayner, Hebbel: Circulating activated endothelial cells in sickle cell anemia. in The New England journal of medicine 1997 (PubMed)
    Show all 3 Pubmed References

  3. Dog (Canine) Monoclonal MCAM Primary Antibody for IHC (f), ICC - ABIN2749195 : Solovey, Gui, Chang, Enenstein, Browne, Hebbel: Identification and functional assessment of endothelial P1H12. in The Journal of laboratory and clinical medicine 2001 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal MCAM Primary Antibody for FACS, IF (p) - ABIN732143 : Hu, Zeng, Jiang, Hu, Meng, Zhu, Mao: The expression of marker for endometrial stem cell and fibrosis was increased in intrauterine adhesious. in International journal of clinical and experimental pathology 2015 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal MCAM Primary Antibody for IHC (fro), FACS - ABIN2478531 : Harper, MacInnes, Campbell, Hall: Increased birth weight in northerly islands: is fish consumption a red herring? in BMJ (Clinical research ed.) 1991 (PubMed)
    Show all 4 Pubmed References

  6. Human Monoclonal MCAM Primary Antibody for FACS - ABIN2478529 : Kuzu, Bicknell, Fletcher, Gatter: Expression of adhesion molecules on the endothelium of normal tissue vessels and vascular tumors. in Laboratory investigation; a journal of technical methods and pathology 1993 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal MCAM Primary Antibody for FACS - ABIN2478527 : Piriou-Guzylack, Salmon: Membrane markers of the immune cells in swine: an update. in Veterinary research 2008 (PubMed)
    Show all 4 Pubmed References

  8. Human Monoclonal MCAM Primary Antibody for FACS - ABIN4896790 : Pilz, Braun, Ulrich, Felka, Warstat, Ruh, Schewe, Abele, Larbi, Aicher: Human mesenchymal stromal cells express CD14 cross-reactive epitopes. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal MCAM Primary Antibody for FACS, IHC - ABIN1724844 : Wang, Yan: CD146, a multi-functional molecule beyond adhesion. in Cancer letters 2013 (PubMed)
    Show all 2 Pubmed References

  10. Human Monoclonal MCAM Primary Antibody for IHC, ELISA - ABIN1724898 : Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells. in The Journal of biological chemistry 2013 (PubMed)
    Show all 2 Pubmed References

More Antibodies against MCAM Interaction Partners

Human Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. CD146 suppresses BC progression as a target of CD44 (show CD44 Antibodies)-downstream signaling

  2. Cultured early passage ASCs contained low levels of CD146 mRNA, which was expressed in two different splicing variants, at a relatively high amount of the CD146-long form and at a relatively low amount of the CD146-short form. ASCs contained low levels of CD146 protein, which consisted predominantly long form and a small amount of short form.

  3. In summary, we have shown that MUC18/Muc18 may serve as a regulator of airway inflammation and mucus overproduction, two important features of type 2-high asthma. Our data suggest that MUC18/Muc18 or its downstream signaling mediators may be targets for potential therapeutic agents.

  4. CD146 promoter polymorphisms were not associated with the risk of clear cell renal carcinoma (show TSC2 Antibodies) in Chinese population. The rs3923594 was an independent predictor of recurrence in with localized ccRCC.

  5. We demonstrate that ER(+) breast cancers contain two CAF subtypes defined by CD146 expression. CD146(neg) CAFs suppress ER expression in ER(+) breast cancer cells, decrease tumor cell sensitivity to estrogen, and increase tumor cell resistance to tamoxifen therapy

  6. CD146 functions as a suppressor of tumorigenesis and cancer stemness in CRC (show CALR Antibodies) through inactivating the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) cascade

  7. These findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment.

  8. CD146 was expressed in all cases of Ph-positive B- cell acute lymphoblastic leukemia and in the vast majority of T-cell acute lymphoblastic leukemia

  9. Our results suggest that MCAM may serve as a novel therapeutic target to overcome chemoresistance in SCLC.

  10. Authors show that KDM3A (show KDM3A Antibodies) regulates MCAM expression both through a direct mechanism, involving modulation of H3K9 methylation at the MCAM promoter, and an indirect mechanism, via the Ets1 (show ETS1 Antibodies) transcription factor.

Mouse (Murine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. The dynamic expression of CD146 controls the behavior of ECs and pericyte.

  2. In summary, we have shown that MUC18/Muc18 may serve as a regulator of airway inflammation and mucus overproduction, two important features of type 2-high asthma. Our data suggest that MUC18/Muc18 or its downstream signaling mediators may be targets for potential therapeutic agents.

  3. These findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment.

  4. Activation of the proteolytic processing of short isoform CD146, in particular by soluble CD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases.

  5. Study shows that Mcam is upregulated in cells that have a migratory phenotype upon MEIS1 (show MEIS1 Antibodies) overexpression and identi fi ed a MEIS1 (show MEIS1 Antibodies) consensus site 113 kb upstream of the Mcam tran- scriptional start site.

  6. Different intrinsic co-factors in different K1735 sublines, which modulate the functions of MCAM/MUC18 in the cells that interact differently to the tumor microenvironment, may render sublines manifest differently in tumorigenicity and metastasis in vivo.

  7. Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro.

  8. Microphthalmia-associated transcription factor (show MITF Antibodies) regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule

  9. Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver.

  10. Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1 (show NTN1 Antibodies)-induced angiogenesis.

Pig (Porcine) Melanoma Cell Adhesion Molecule (MCAM) interaction partners

  1. expression of FLK1 (show KDR Antibodies), CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.

MCAM Antigen Profile

Protein Summary

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene names and symbols associated with MCAM

  • melanoma cell adhesion molecule (MCAM) antibody
  • melanoma cell adhesion molecule (Mcam) antibody
  • 1-gicerin antibody
  • AV025631 antibody
  • CD146 antibody
  • CD149 antibody
  • MCAM antibody
  • Muc18 antibody
  • s-endo antibody
  • s-gicerin antibody

Protein level used designations for MCAM

Gicerin , S-endo 1 endothelial-associated antigen , cell surface glycoprotein MUC18 , cell surface glycoprotein P1H12 , melanoma adhesion molecule , melanoma-associated antigen A32 , melanoma-associated antigen MUC18 , gicerin , l-gicerin , l-gicerin protein , HEMCAM , melanoma cell adhesion molecule , cell surface glycoprotein MUC18-like

GENE ID SPECIES
4162 Homo sapiens
78967 Rattus norvegicus
84004 Mus musculus
281301 Bos taurus
448832 Gallus gallus
489368 Canis lupus familiaris
733617 Sus scrofa
744688 Pan troglodytes
100071414 Equus caballus
100454353 Pongo abelii
100470323 Ailuropoda melanoleuca
100718224 Cavia porcellus
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