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associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane [RGD, Feb 2006].. Additionally we are shipping MAGI3 Antibodies (14) and many more products for this protein.
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The altered mRNA isoform, called MAGI3(pPA (show PPA1 Proteins)), produces a truncated protein that acts in a dominant-negative manner to prevent full-length MAGI3 from interacting with the YAP (show YAP1 Proteins) oncoprotein, thereby relieving YAP (show YAP1 Proteins) inhibition and promoting malignant transformation of human mammary epithelial cells.
Results identify MAGI3 as a novel tumor suppressor and provide insight into the pathogenesis of glioma.
Expression levels of MAGI3 and PTEN were significantly downregulated in gliomas.
MAGI-3 competes with NHERF-2 (show SLC9A3R2 Proteins) to negatively regulate LPA2 (show LPAR2 Proteins) receptor signaling in colon cancer cells.
Oncogenic human papillomavirus E6 proteins target the MAGI-2 (show MAGI2 Proteins) and MAGI-3 proteins for degradation [MAGI-2 (show MAGI2 Proteins), MAGI-3]
In epithelial cells, MAGI-3 was localized with ZO-1 (show TJP1 Proteins) and cingulin at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin (show CDH1 Proteins)-based cell-cell contacts and in focal adhesion sites.
These results demonstrate that MAGI-3 interacts directly with LPA(2 (show LPAR2 Proteins)) and regulates the ability of LPA(2 (show LPAR2 Proteins)) to activate Erk (show EPHB2 Proteins) and RhoA (show RHOA Proteins).
All of the E6 genes from different HPV types displayed similar abilities to mediate the degradation of both p53 (show TP53 Proteins) and MAGI-3
MAGI-3 has a role in efficient trafficking of TGFalpha to the cell surface in polarized epithelial cells.
associates with tyrosine-phosphorylated proteins to link the receptor with its substrate in the plasma membrane
, membrane-associated guanylate kinase inverted 3
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
, membrane-associated guanylate kinase-related (MAGI-3)
, scaffolding protein SLIPR
, scaffolding-like protein
, membrane-associated guanylate kinase-related 3