Metal-Regulatory Transcription Factor 1 (MTF1) ELISA Kits

Zebrafish Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

1. The functional characterization of a complete zebrafish MTF-1, is reported.

2. MTF1 is a master regulator of gene expression during development.

Mouse (Murine) Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

1. Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

2. MTF1 mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.

3. the presence of SUMO moiety allows the MTF-1 protein to interact directly with metal-responsive element

4. nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 by antagonizing metal-responsive transcription factor-1.

5. MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc.

6. PTEN associates with MTF-1 in cells in response to oxidative stress and in zinc homeostasis.

7. Results reveal a novel repressive role for MTF-1 in the regulation of the Zip10 zinc transporter expression by pausing Pol II transcription.

8. Data show that disruption of nucleosome structure at the MT-I promoter is mediated by zinc-responsive recruitment of an active MTF-1-coactivator complex.

9. Zinc and cadmium can activate FPN1 transcription through the MTF-1.

10. mouse MTF-1 is polymorphic

11. Zinc finger domains 1, 3, and 6 of MTF1, in particular domains 1 and 6, show lower metal ion affinities and remain as the most likely candidates if the Cys2His2 metal ion-binding sites of MTF1 are, indeed, responsible for zinc sensing in vivo.

12. MTF1 plays a critical role in embryonic liver formation, heavy metal toxicity, and hematopoiesis.

13. MTF-1 enhances the ability of the developing tumor mass to evade fibrosis and scarring of the tumor, a critical step in tumor cell proliferation.

14. Highly inducible strains having Mtf-1 of proline type are refractory to radiation effects and hence are resistant to lymphoma development.

15. Zinc sensing by MTF-1 in eukaryotic cells involves multiple zinc fingers and occurs over a 100-fold or less range of accessible Zn(II) concentration.

16. Together, these novel findings define a role for MTF-1 in the regulation of HIF-1 activity.

17. New MTF-1 target genes with metal response elements motifs in the promoter region were identified.

18. Results suggest a mechanism by which physiological concentrations of accessible cellular zinc affect MTF-1 activity.

19. We also show that large thymocytes with higher ROS levels and a proliferation capacity were more numerous in the Mtf-1 susceptible mice than the resistant mice when examined at 7 days after irradiation.

20. Nuclear factor-1 acts synergistically with MTF-1 to activate the mouse metallothionein-1 promoter in response to metal ions

Human Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

1. MTF1 heads a hierarchy of zinc sensors, and through controlling the expression of a raft of metallothioneins and other key proteins involved in controlling intracellular zinc levels (e.g. ZnT1) alters zinc buffering capacity and total cellular zinc content.

2. MTF-1 has a role in regulating zinc dependent cellular processes at the molecular level [review]

3. Forty-one single nucleotide polymorphisms (SNPs) within the MTF1 gene region.

4. Human ZnT2 expression is regulated by MTF-1.

5. Zn-responsive proteome profiling and time-dependent expression of proteins are regulated by MTF-1 in human alveolar epithelial cells.

6. The zinc-sensing cytoplasmic transcription factor MTF-1 plays a key role in cellular zinc homoeostasis.

7. Results identify a cysteine cluster that mediates homodimerization of human MTF-1, and show that dimer formation in vivo is important for basal and especially metal-induced transcriptional activity.

8. Variations in the ability of LAT1/DMT1/MTF1/MT1a to process and transport Hg may not play a significant role in the etiology of autism.

9. It is concluded that SUMO conjugation and the SIM on MTF-1 do not play a critical role in suppressing transcriptional activity. Instead, MTF-1 forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm

10. Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.

11. Zinc and cadmium can activate FPN1 transcription through the MTF-1.

12. Data show that hepcidin transcription involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1.

13. Genetic regulation via sequences downstream of promoters highlights a new direction for identifying previously unrecognized target genes for MTF-1.

14. Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in intrahepatic cholangiocarcinoma

15. role in regulating metallothionein transcription

16. MTF1 transactivation potential is affected by chromium levels

17. mediates transcriptional hyperactivation along with heat and heavy metal stress

18. MTF-1 contains a cysteine-rich cluster, -632Cys-Gln-Cys-Gln-Cys-Ala-Cys638-, which appears to be specifically required for MTF-1 to activate transcription in the presence of inducing heavy metal ions.

19. The MTF-1 serves targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration and under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene PIGF.

20. SP1 and MTF-1 represent new targets in the development of key therapeutics toward modulating the expression of the cellular prion protein and ultimately the prevention of prion disease