Metastasis Suppressor 1 Proteins (MTSS1)

May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.. Additionally we are shipping MTSS1 Antibodies (69) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTSS1 9788 O43312
MTSS1 211401 Q8R1S4
Rat MTSS1 MTSS1 362918  
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Top MTSS1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Escherichia coli (E. coli) Human MBP tag,His tag 50 μg Log in to see 14 to 16 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

MTSS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Metastasis Suppressor 1 (MTSS1) Interaction Partners

Human Metastasis Suppressor 1 (MTSS1) interaction partners

  1. In vitro data suggests MTSS1 regulates lung adenocarcinoma through augmentation of cell invasion and migration.

  2. MTSS1 is stabilized by the protein phosphatase activity of the tumor suppressor PTEN. Our data show that PTEN loss in PDAC cells results in both increased metastatic potential and decreased MTSS1 expression. Furthermore, we show that ectopic MTSS1 expression rescues this effect.

  3. These data suggested that miR-411 played as oncogene in the osteosarcoma partly by inhibiting the MTSS1 expression. .

  4. Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.

  5. Data identify MTSS1 as a new Akt2-regulated gene, and point to suppression of MTSS1 as a key step in the metastasis-promoting effects of Akt2 in CRC cells.

  6. Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1.

  7. Overexpression of MTSS1 in PDAC cell lines leads to a loss of migratory potential in vitro and an increase in overall survival in vivo. Data provide insight into an important role for MTSS1 in suppressing tumor cell invasion and migration driven by the tumor microenvironment.

  8. Overexpression of MTSS1 reduced BUCC cell proliferation, cell-cycle progression and colony formation, but had no influence on BUCC cell apoptosis.

  9. in contrast to MIM, which is a prototype of I-BAR proteins and does not contain an SH3 domain, IRTKS promoted serum-induced cell migration along with enhanced phosphorylation of mitogen activated kinases Erk1/2 and p38

  10. this study shows a previously unknown property of MIM that establishes the linkage of protein ubiquitylation with Rab-guided trafficking of CXCR4 in endocytic vesicles

  11. MTSS1 suppressed H1299 cell migration and invasion, and its expression level can be used as a new independent factor for determining the prognosis of non-small cell lung cancer.

  12. MTSS1 is a new authentic target of miR-96 in prostate carcinoma.

  13. Down-regulation of MTSS1 expression is associated with lymph node metastasis in Pancreatic Cancer.

  14. Low expression of Mtss1 is associated with Chronic myeloid leukemia.

  15. MTSS1 plays an essential inhibitory role in the development and progression of ovarian cancers

  16. human breast tumors data sets the MTSS1/p63 co-expression is a negative prognostic factor on patient survival, suggesting that the MTSS1/p63 axis might be functionally important to regulate breast tumor progression

  17. our findings suggest that MTSS1 might have a context-dependent function and could act as a tumor suppressor, which is pharmacologically targetable in AML patients.

  18. EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer.

  19. These results implicate that the role of MTSS1 suppresses cell migration and invasion by inhibiting expression of CTTN and as a prognosis biomarker in Glioblastomas

  20. Data shows that MTSS1 is highly expressed in non-small-cell lung carcinomas compared with non-neoplastic lung tissues and may serve as an independent prognostic factor.

Mouse (Murine) Metastasis Suppressor 1 (MTSS1) interaction partners

  1. Mtss1(CSC156) mutant mice fail to display efficient Mtss1 protein depletion.

  2. Mtss1 is a key linker between the actin cytoskeleton and the cell membrane, for the development and maintenance of a paradigmatic neuronal circuit, the cerebellar cortex.

  3. Study showed that MTSS1 regulates neurite outgrowth and dendritic arborization in primary neurons in vitro, possibly through a Rac1- and PIP-dependent pathway.

  4. role of MIM in the homeostasis of BM cells, including HSPCs, through modulation of the CXCR4/SDF-1 axis and interactions of BM leukocytes with their microenvironments.

  5. Identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of dendritic spines. MIM accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protrusion via its I-BAR domain.

  6. The data demonstrated for the first time an important role for missing-in-metastasis protein in B-cell development. There was a predisposition of missing-in-metastasis-null mice to develop diffuse large B lymphomas.

  7. MTSS1 might be involved in shaping neuronal membranes in vivo.

  8. endogenous MIM protein regulates globally the cell architecture and endocytosis that ultimately influence a variety of cellular behaviors, including cell polarity, motility, receptor signaling and membrane ruffling

  9. MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.

  10. Results suggest that MIM promotes ciliogenesis by antagonizing Src-dependent phosphorylation of Cortactin and describe a mechanism linking regulation of the actin cytoskeleton with ciliogenesis and Shh signaling during tissue regeneration.

  11. tissue-specific regulator of cytoskeletal dynamics that interacts with ATP-actin monomers through its C-terminal WH2 domain

  12. Hedgehog-responsive gene MIM cooperates with receptor protein tyrosine phosphatase-delta to induce cytoskeletal remodeling.

  13. Mtss1 represents a novel signaling pathway from PDGF receptor to the actin cytoskeleton via Src-related kinases.

  14. The crystal structures of MIM's IMD and that of its WH2 bound to actin was determined.

  15. potential role of Mtss1 for cytoskeletal dynamics in developing and mature cerebellar neurons

Xenopus laevis Metastasis Suppressor 1 (MTSS1) interaction partners

  1. morphogenetic pathway involving Daam1 and MIM that transduces non-canonical Wnt signaling for the cytoskeletal changes and membrane dynamics required for vertebrate neural tube closure

MTSS1 Protein Profile

Protein Summary

May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

Gene names and symbols associated with MTSS1

  • MTSS1, I-BAR domain containing (MTSS1)
  • transmembrane protein 65 (TMEM65)
  • metastasis suppressor protein 1 (LOC100547471)
  • MTSS1, I-BAR domain containing (mtss1)
  • metastasis suppressor 1 (Mtss1)
  • MTSS1, I-BAR domain containing (Mtss1)
  • metastasis suppressor 1, gene 2 L homeolog (mtss1.2.L)
  • 2310003N14Rik protein
  • BC024131 protein
  • D130001D01Rik protein
  • mim protein
  • mima protein
  • mimb protein
  • mKIAA0429 protein
  • mtss1 protein

Protein level used designations for MTSS1

metastasis suppressor 1 , metastasis suppressor protein 1 , metastasis suppressor protein 1-like , metastasis suppressor YGL-1 , missing in metastasis protein , actin monomer-binding protein

711465 Macaca mulatta
100080535 Ornithorhynchus anatinus
100157797 Sus scrofa
100174755 Pongo abelii
100355361 Oryctolagus cuniculus
100410891 Callithrix jacchus
100467780 Ailuropoda melanoleuca
100547471 Meleagris gallopavo
100559325 Anolis carolinensis
100582996 Nomascus leucogenys
464381 Pan troglodytes
9788 Homo sapiens
482037 Canis lupus familiaris
100067482 Equus caballus
523498 Bos taurus
211401 Mus musculus
362918 Rattus norvegicus
420336 Gallus gallus
447209 Xenopus laevis
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