MTSS1 Protein (AA 1-250) (His tag,MBP tag)

Catalog No. ABIN7317313

Product Details

Target: MTSS1 (Metastasis Suppressor 1 (MTSS1))

Protein Type: Recombinant

Protein Characteristics: AA 1-250

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This MTSS1 protein is labelled with His tag,MBP tag.

Purpose: Recombinant Human MTSS1 Protein (aa1-250, His & MBP Tag)

Sequence: Met 1-Ser 250

Characteristics: A DNA sequence encoding the human MTSS1 (EAW92073.1) N-terminal fragment (Met 1-Ser 250) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus.

Purity: > 80 % as determined by reducing SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: MTSS1 (Metastasis Suppressor 1 (MTSS1))

Alternative Name: MTSS1 (MTSS1 Products)

Synonyms: MTSS1 Protein, MIM Protein, MIMA Protein, MIMB Protein, 2310003N14Rik Protein, BC024131 Protein, D130001D01Rik Protein, Mim Protein, mKIAA0429 Protein, mim Protein, mima Protein, mimb Protein, mtss1 Protein, MTSS1, I-BAR domain containing Protein, transmembrane protein 65 Protein, metastasis suppressor protein 1 Protein, metastasis suppressor 1 Protein, metastasis suppressor 1, gene 2 L homeolog Protein, MTSS1 Protein, TMEM65 Protein, LOC100547471 Protein, mtss1 Protein, Mtss1 Protein, mtss1.2.L Protein

Background:

Background: MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer. The down-regulation of MTSS1 that may be caused by DNA methylation was also observed in many other types of cancer.Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. MTSS1 as a multiple functional molecular player and has an important role in development, carcinogenesis and metastasis.

Synonym: MIM,MIMA,MIMB

Molecular Weight: 71.8 kDa