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Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton.
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One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin (show DBN1 Proteins) and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 (show CDK5 Proteins) phosphorylation of drebrin (show DBN1 Proteins) but the upstream elements in the pathway have yet to be identified.
EB1 (show MAPRE2 Proteins) and EB3 thus affect multiple interphase processes and have a major impact on microtubule minus end organization.
Findings show that co-ordination of dynamic microtubules and actin filaments by the drebrin (show DBN1 Proteins)/EB3 pathway drives prostate cancer cell invasion and is therefore implicated in disease progression.
Aptamers binding to human EB1 (show MAPRE2 Proteins) and EB3, which have sequence requirements similar to but distinct from each other and from Drosophila EB1 (show MAPRE2 Proteins), were identified.
EB1 (show MAPRE2 Proteins) and EB3 proteins are obligatory dimers.
Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 (show IRX3 Proteins) genes may play an important role in a pathogenic effect of TGF-beta (show TGFB1 Proteins) on RASFs.
Daughter cell adhesion and cytokinesis completion are spatially regulated by distinct states of EB3 phosphorylation on serine 176 by Aurora B (show AURKB Proteins).
decreasing the drebrin E (show DBN1 Proteins) levels disrupted the normal subapical F-actin-myosin-IIB-betaII-spectrin network and the apical accumulation of EB3, a microtubule-plus-end-binding protein
VE-cadherin (show CDH5 Proteins) outside-in signaling regulates cytosolic calcium homeostasis and EB3 phosphorylation.
Data indicated that EB1 (show MAPRE2 Proteins) and EB3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that EB1 (show MAPRE2 Proteins) and EB3 promote ciliogenesis by facilitating such trafficking.
EB3 binds to IP3 receptors, promotes IP3R (show ITPR1 Proteins) clustering and Ca2 (show CA2 Proteins)+ signals in endothelial cells.
MAP1B (show MAP1B Proteins) interacts directly with EB1 (show MAPRE1 Proteins) and EB3 (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.
DDA3 (show PSRC1 Proteins) is a novel microtubule-associated protein (show SPAG5 Proteins) that binds to EB3, and results implicate DDA3 (show PSRC1 Proteins) and EB3 in the beta-catenin (show CTNNB1 Proteins)-mediated growth signaling.
Two +TIPs, CLIP-170 and end-binding protein 3 (EB3), turn over rapidly on MT ends. Diffusion of CLIP-170 and EB3 appears to be rate limiting for their binding to MT plus ends.
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
microtubule-associated protein, RP/EB family, member 3
, APC binding protein
, EB1 protein family member 3
, end-binding protein 3
, microtubule-associated protein RP/EB family member 3