Midline 1 Proteins (MID1)

The protein encoded by MID1 is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins.

list all proteins Gene Name GeneID UniProt
Human MID1 MID1 4281 O15344
Mouse MID1 MID1 17318 O70583
Rat MID1 MID1 54252 P82458
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Top MID1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Mouse His tag   1 mg Log in to see 60 to 71 Days
$2,200.00
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,936.17
Details
Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg Log in to see 15 to 18 Days
$720.00
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$582.75
Details

More Proteins for Midline 1 (MID1) Interaction Partners

Human Midline 1 (MID1) interaction partners

  1. Data show that protein phosphatase-2A (PP2A (show PPP2R4 Proteins)) was upregulated in lung adenocarcinoma cell lines that were transfected with midline 1 E3 ubiquitin-protein ligase (show UBE2K Proteins) (MID1)-siRNA, suggesting MID1 negatively regulates PP2A (show PPP2R4 Proteins) in lung adenocarcinoma.

  2. identified four miRNAs, miR (show MLXIP Proteins)-19, miR (show MLXIP Proteins)-340, miR (show MLXIP Proteins)-374 and miR (show MLXIP Proteins)-542 that bind to the 3'-UTR of the MID1 mRNA. These miRNAs not only regulate MID1 expression but also mTOR (show FRAP1 Proteins) signaling and translation of disease associated mRNAs and could therefore serve as potential drugs for future therapy development

  3. Our data reveal a novel role for MID1 and for atypical ubiquitination in balancing BRAF35 (show HMG20B Proteins) presence, and likely its activity, within nuclear and cytoplasmic compartments

  4. P151L MID1 mutation is associated with X-linked Opitz Syndrome.

  5. the coiled-coil and COS domain (CC-COS) bind to microtubules, demonstrating for the first time that MID1 can directly associate with the microtubules

  6. Osx is upregulated in patients with Ossification of the posterior longitudinal ligament.

  7. A130T/V mutations within the MID1 zinc-binding Bbox1 (show BBOX1 Proteins) domain affects protein folding.

  8. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 (show BBOX1 Proteins) domain disrupt polyubiquitination of alpha4 but not of PP2Ac (show PPP2CA Proteins) in X-linked Opitz syndrome.

  9. TRAIL regulates MID1 and TSLP (show TSLP Proteins), inflammation, fibrosis, smooth muscle hypertrophy, and expression of inflammatory effector chemokines and cytokines in experimental eosinophilic esophagitis.

  10. These studies provide insight into the mechanism by which mutations observed in X-linked Opitz G syndrome affect the structure and function of the MID1 Bbox1 (show BBOX1 Proteins) domain

Mouse (Murine) Midline 1 (MID1) interaction partners

  1. we show that MID1 controls exocytosis of lytic granules and cytotoxicity in murine cytotoxic lymphocytes

  2. X-linked microtubule-associated protein (show SPAG5 Proteins), Mid1, regulates axon development.

  3. MID1 inhibition also limited rhinovirus-induced exacerbation of allergic airway disease

  4. Thus, lack of Mid1 causes a misspecification of the midbrain/cerebellar boundary that results in an abnormal development of the most anterior cerebellar lobes.

  5. Analysis of Mid1, Hccs (show HCCS Proteins), Arhgap6 (show ARHGAP6 Proteins), and Msl3l1 (show MSL3 Proteins) in X-linked polydactyly (Xpl) and Patchy-fur (Paf (show PAF Proteins)) mutant mice

Xenopus laevis Midline 1 (MID1) interaction partners

  1. SHH (show SHH Proteins)-dependent E-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 (show PAX6 Proteins) during visual system development.

MID1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing\; however, the full-length nature of some of the variants has not been determined.

Gene names and symbols associated with Midline 1 Proteins (MID1)

  • midline 1 (MID1)
  • midline 1 (Mid1)
  • midline 1 (mid1)
  • midline 1 L homeolog (mid1.L)
  • 61B3-R protein
  • bbbg1 protein
  • DXHXS1141 protein
  • fxy protein
  • gbbb1 protein
  • midin protein
  • Midline1 protein
  • ogs1 protein
  • OS protein
  • osx protein
  • rnf59 protein
  • trim18 protein
  • xprf protein
  • znfxy protein

Protein level used designations for Midline 1 Proteins (MID1)

RING finger protein 59 , midline 1 RING finger protein , midline-1 , putative transcription factor XPRF , tripartite motif protein TRIM18 , tripartite motif-containing protein 18 , zinc finger on X and Y, mouse, homolog of , midin , Finger on X and Y (in rat only on X) , E3 ubiquitin-protein ligase Midline-1 , midline 1 (Opitz/BBB syndrome)

GENE ID SPECIES
4281 Homo sapiens
17318 Mus musculus
54252 Rattus norvegicus
373920 Gallus gallus
100330952 Danio rerio
100463496 Xenopus laevis
491737 Canis lupus familiaris
534604 Bos taurus
100524415 Sus scrofa
100716416 Cavia porcellus
100049999 Equus caballus
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