MID1 Proteins

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing\; however, the full-length nature of some of the variants has not been determined.

Gene names and symbols associated with Midline 1 Proteins (MID1)

• midline 1 (MID1) antibody
• midline 1 (Mid1) antibody
• midline 1 (mid1) antibody
• midline 1 L homeolog (mid1.L) antibody

• 61B3-R antibody
• bbbg1 antibody
• DXHXS1141 antibody
• fxy antibody
• gbbb1 antibody
• Show all synonym aliases
• midin antibody
• Midline1 antibody
• ogs1 antibody
• OS antibody
• osx antibody
• rnf59 antibody
• trim18 antibody
• xprf antibody
• znfxy antibody

Protein level used designations for Midline 1 Proteins (MID1)

RING finger protein 59 , midline 1 RING finger protein , midline-1 , putative transcription factor XPRF , tripartite motif protein TRIM18 , tripartite motif-containing protein 18 , zinc finger on X and Y, mouse, homolog of , midin , Finger on X and Y (in rat only on X) , E3 ubiquitin-protein ligase Midline-1 , midline 1 (Opitz/BBB syndrome)