Midline 1 Proteins (MID1)

The protein encoded by MID1 is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. Additionally we are shipping MID1 Antibodies (62) and MID1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MID1 4281 O15344
MID1 17318 O70583
MID1 54252 P82458
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Top MID1 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
Details
Yeast Mouse His tag   1 mg 60 to 71 Days
$2,200.00
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$3,936.17
Details
Escherichia coli (E. coli) Mouse T7 tag,His tag 100 μg 15 to 18 Days
$720.00
Details

MID1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Midline 1 (MID1) Interaction Partners

Human Midline 1 (MID1) interaction partners

  1. TRAIL in serum and MID1 protein levels in biopsies from Idiopathic pulmonary fibrosis patients were increased compared to controls. TRAIL signalling through MID1 deactivates protein phosphatase 2A and promotes fibrosis with corresponding lung function decline.

  2. Data show that protein phosphatase-2A (PP2A) was upregulated in lung adenocarcinoma cell lines that were transfected with midline 1 E3 ubiquitin-protein ligase (MID1)-siRNA, suggesting MID1 negatively regulates PP2A in lung adenocarcinoma.

  3. identified four miRNAs, miR-19, miR-340, miR-374 and miR-542 that bind to the 3'-UTR of the MID1 mRNA. These miRNAs not only regulate MID1 expression but also mTOR signaling and translation of disease associated mRNAs and could therefore serve as potential drugs for future therapy development

  4. Our data reveal a novel role for MID1 and for atypical ubiquitination in balancing BRAF35 presence, and likely its activity, within nuclear and cytoplasmic compartments

  5. P151L MID1 mutation is associated with X-linked Opitz Syndrome.

  6. the coiled-coil and COS domain (CC-COS) bind to microtubules, demonstrating for the first time that MID1 can directly associate with the microtubules

  7. Osx is upregulated in patients with Ossification of the posterior longitudinal ligament.

  8. A130T/V mutations within the MID1 zinc-binding Bbox1 domain affects protein folding.

  9. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac in X-linked Opitz syndrome.

  10. TRAIL regulates MID1 and TSLP, inflammation, fibrosis, smooth muscle hypertrophy, and expression of inflammatory effector chemokines and cytokines in experimental eosinophilic esophagitis.

  11. These studies provide insight into the mechanism by which mutations observed in X-linked Opitz G syndrome affect the structure and function of the MID1 Bbox1 domain

  12. A familial c.1102C>T (p.R368X) mutation in the MID1 gene, is reported.

  13. Results revealed S422 as a novel phosphorylation site of Osx and GSK-3b played an important role in regulating the protein stability and transactivational activity of Osx.

  14. Fu ubiquitination and cleavage is one of the key elements connecting the MID1-PP2A protein complex with GLI3 activity control

  15. Promotion of AR, in addition to enhancement of the Akt-, NFkappaB-, and Hh-pathways by sustained MID1-upregulation during androgen deprivation therapy provides a powerful proliferative scenario for PCa progression into castration resistance

  16. In prostate cancer cells the inhibitory effect of metformin was mimicked by disruption of MID1 translational regulator complex.

  17. Two patients with underdeveloped arcuate fasciculus had novel, nonsynonymous variants in MID1 and EN2 genes regulating axon guidance pathway.

  18. for the first time within the MID1 gene, a complex rearrangement composed of two deletions, an inversion and a small insertion that may suggest the involvement of concurrent non-homologous mechanisms in the generation of the observed structural variant.

  19. expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase.

  20. found that MID1 was upregulated in primary human bronchial epithelial cells

Mouse (Murine) Midline 1 (MID1) interaction partners

  1. MID1 levels were inversely associated while PP2A activity levels correlated with DLco. Tnfsf10(-/-) and mice treated with the protein phosphatase 2A (PP2A) activator AAL(s) were largely protected against bleomycin-induced reductions in lung function and fibrotic changes. TRAIL signalling through MID1 deactivates PP2A and promotes fibrosis with corresponding lung function decline.

  2. Study shows that pharmacological disruption of the MID1/alpha4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.

  3. we show that MID1 controls exocytosis of lytic granules and cytotoxicity in murine cytotoxic lymphocytes

  4. X-linked microtubule-associated protein, Mid1, regulates axon development.

  5. MID1 inhibition also limited rhinovirus-induced exacerbation of allergic airway disease

  6. Thus, lack of Mid1 causes a misspecification of the midbrain/cerebellar boundary that results in an abnormal development of the most anterior cerebellar lobes.

  7. Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf) mutant mice

Xenopus laevis Midline 1 (MID1) interaction partners

  1. SHH-dependent E-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development.

MID1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing\; however, the full-length nature of some of the variants has not been determined.

Gene names and symbols associated with Midline 1 Proteins (MID1)

  • midline 1 (MID1)
  • midline 1 (Mid1)
  • midline 1 (mid1)
  • midline 1 L homeolog (mid1.L)
  • 61B3-R protein
  • bbbg1 protein
  • DXHXS1141 protein
  • fxy protein
  • gbbb1 protein
  • midin protein
  • Midline1 protein
  • ogs1 protein
  • OS protein
  • osx protein
  • rnf59 protein
  • trim18 protein
  • xprf protein
  • znfxy protein

Protein level used designations for Midline 1 Proteins (MID1)

RING finger protein 59 , midline 1 RING finger protein , midline-1 , putative transcription factor XPRF , tripartite motif protein TRIM18 , tripartite motif-containing protein 18 , zinc finger on X and Y, mouse, homolog of , midin , Finger on X and Y (in rat only on X) , E3 ubiquitin-protein ligase Midline-1 , midline 1 (Opitz/BBB syndrome)

GENE ID SPECIES
4281 Homo sapiens
17318 Mus musculus
54252 Rattus norvegicus
373920 Gallus gallus
100330952 Danio rerio
100463496 Xenopus laevis
491737 Canis lupus familiaris
534604 Bos taurus
100524415 Sus scrofa
100716416 Cavia porcellus
100049999 Equus caballus
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