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Mitochondrial Transcription Termination Factor Proteins (MTERF)

MTERF encodes a mitochondrial transcription termination factor. Additionally we are shipping Mitochondrial Transcription Termination Factor Antibodies (49) and Mitochondrial Transcription Termination Factor Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTERF 85261 Q9EPI8
Mouse MTERF MTERF 545725 Q8CHZ9
MTERF 7978 Q99551
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Top Mitochondrial Transcription Termination Factor Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,911.33
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human MTERF Protein. 100 μg Log in to see 11 to 18 Days
$582.75
Details

MTERF Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
, ,

More Proteins for Mitochondrial Transcription Termination Factor (MTERF) Interaction Partners

Mouse (Murine) Mitochondrial Transcription Termination Factor (MTERF) interaction partners

  1. MTERF1 does not regulate heavy-strand transcription, but rather acts to block transcription on the opposite strand of mtDNA to prevent transcription interference at the light-strand promoter.

Human Mitochondrial Transcription Termination Factor (MTERF) interaction partners

  1. MTERF1 has the ability to accommodate alternate active conformations.

  2. It has been demonstrated that MTERF1 arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE.

  3. Studies indicate that the structure of the mitochondrial transcription termination factor (MTERF1) provides insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination.

  4. Single nucleotide polymorphism in MTERF gene is associated with epithelial ovarian cancer.

  5. Data show that mTERF protein levels materially affect the amount of readthrough transcription on the antisense strand of mtDNA, whilst the effects on sense-strand transcripts are complex, and suggest the influence of compensatory mechanisms.

  6. Presented are the crystal structures of human mitochondrial regulator MTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence.

  7. The structure indicates that upon sequence recognition MTERF1 unwinds the DNA molecule, promoting eversion of three nucleotides.

  8. mTERF mRNA levels were higher in elite athletes compared with moderately active subjects

  9. mTERF exists in mitochondria in two forms, an active monomer and an inactive large size complex

  10. monomeric human mTERF is fully active in its non-phosphorylated form and that the protein does not require additional cellular factors to terminate mitochondrial transcription in vitro

Fruit Fly (Drosophila melanogaster) Mitochondrial Transcription Termination Factor (MTERF) interaction partners

  1. mTerf5 knockdown led to enhanced replication pausing at mTTF binding sites, a decrease in fragile replication intermediates containing single-stranded segments, and the disappearance of species containing segments of RNA/DNA hybrid

  2. The first ever-obtained evidence for an in vivo role of an animal mitochondrial transcription termination factor.

  3. DmTTF might play multiple roles in the mtDNA transcription process, for which different levels of the protein with respect to mtRNApol are required.

Mitochondrial Transcription Termination Factor (MTERF) Protein Profile

Protein Summary

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome\; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding.

Gene names and symbols associated with MTERF

  • mitochondrial transcription termination factor 1 (MTERF1)
  • mitochondrial transcription termination factor (MTERF)
  • mitochondrial transcription termination factor 1 (Mterf1)
  • mitochondrial transcription termination factor 1a (Mterf1a)
  • mitochondrial transcription termination factor 1 (mterf1)
  • mitochondrial transcription termination factor (mTTF)
  • 4931431L11Rik protein
  • 9230106K09Rik protein
  • BG:DS01068.4 protein
  • CG18124 protein
  • Dmel\\CG18124 protein
  • DmTTF protein
  • DS01068.4 protein
  • Mterf protein
  • Mterf1 protein

Protein level used designations for MTERF

mitochondrial transcription termination factor , Transcription termination factor, mitochondrial , mitochondrial transcription termination factor 1 , transcription termination factor, mitochondrial , CG18124-PA , mTTF-PA , transcription termination factor 1, mitochondrial

GENE ID SPECIES
703725 Macaca mulatta
472439 Pan troglodytes
100172789 Pongo abelii
85261 Rattus norvegicus
522191 Bos taurus
545725 Mus musculus
549783 Xenopus (Silurana) tropicalis
7978 Homo sapiens
34837 Drosophila melanogaster
100355865 Oryctolagus cuniculus
100716389 Cavia porcellus
100516386 Sus scrofa
100684053 Canis lupus familiaris
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