anti-Motor Neuron and Pancreas Homeobox 1 (MNX1) Antibodies

MNX1 encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Additionally we are shipping MNX1 Kits (7) and MNX1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MNX1 3110 P50219
MNX1 15285  
MNX1 682076  
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Top anti-MNX1 Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-MNX1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Mnx1 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Testis 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of MNX1 Antibody (Center) in mouse liver tissue lysates (35ug/lane). This demonstrates the MNX1 antibody detected the MNX1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of MNX1 using LOVO whole  lysates. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Chicken Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB MNX1 Antibody (Center)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MNX1 antibody detected the MNX1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis in mouse liver tissue lysates (35ug/lane). 400 μL Log in to see 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB 100 μg Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$293.00
Details

Top referenced anti-MNX1 Antibodies

  1. Mouse (Murine) Polyclonal MNX1 Primary Antibody for IHC (fro), IF - ABIN549019 : Harrison, Thaler, Pfaff, Gu, Kehrl: Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. in Nature genetics 1999 (PubMed)
    Show all 2 Pubmed References

More Antibodies against MNX1 Interaction Partners

Human Motor Neuron and Pancreas Homeobox 1 (MNX1) interaction partners

  1. MNX1 may directly regulate TrkB expression, which may increase their metastatic potential via suppression of anoikis and enhanced adhesion to the ECM.

  2. Pathogenic variants in MNX1 were detected in 28% of all CS cases and 25% of sporadic cases. The clinical phenotype was variable in patients with and without pathogenic variants; no significant genotype-phenotype correlation was observed.

  3. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting.

  4. MNX1 as a novel targetable oncogene increased in African-American (AA) prostate cancer that is associated with aggressive disease.

  5. Findings demonstrated for the first time that lncRNA MNX1-AS1 functions as an oncogene in ovarian cancer.

  6. The results illustrated miR-200a and miR-141 could inhibit the expression of Hlxb9 by binding to its mRNA 3'UTR. Furthermore, the expression of miR-200a and miR-141 was almost reciprocal to that of Hlxb9. Overexpression of miR-200a and miR-141 downregulated the expression of pancreatic progenitor cell markers Hlxb9

  7. The nuclear positioning of the HLXB9 gene was monitored at different stages.

  8. study reports the results of MNX1 mutational screening in a series of 28 cases suspected having Currarino Syndrome and characterization of 10 novel mutations

  9. NKX2-2 and MNX1 are etiological genes for neonatal diabetes.

  10. Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas)

  11. study describes a Norwegian family with typical Currarino syndrome in which a heterozygous deletion removes the entire MNX1 gene but no other known genes; also report MNX1 mutations in 3other Norwegian families and confirm that the GCC12 repeat (c.373_375[12]) is a normal allelic variant

  12. HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells.

  13. a new HLXB9 gene mutation identified in a Chinese family with members suffering from Currarino syndrome

  14. two novel mutations in the MNX1 gene in cases with Currarino syndrome

  15. 2 previously described mutations, 1 de novo nonsense mutation (p.Gln212X) & 1 maternally inherited frameshift mutation (p.Pro18ProfsX38)were found among 14 Currarino syndrome patients with presacral tumors.

  16. Hypermethylation of HLXB9 results in loss of expression and is associated with acute lymphoblastic leukemia.

  17. HLXB9 is overexpressed in patients with infantile acute myeloid leukemia.

  18. Incomeplete Curarino syndrome with more advantageous prognosis with autosomal domiant pattern homebox gene HLXBV9 mutation.

  19. study reports on the MNX1 mutations in a family segregating Currarino syndrome (CS) & 3 sporadic CS patients & on clinical characteristics of the affected individuals

  20. mutation in the HLXB9 transcription factor causes an autosomal dominant form of sacral agenesis

Mouse (Murine) Motor Neuron and Pancreas Homeobox 1 (MNX1) interaction partners

  1. excitatory Hb9::Cre-derived interneurons constitute a distinct population of neurons that participates in the rhythm generating kernel for spinal locomotion.

  2. Inactivating Mnx1 in embryonic beta-cells (Mnx1(Deltabeta)) caused beta-to-delta-like cell transdifferentiation, which was delayed until postnatal stages; findings identify Mnx1 as an important factor in beta-cell differentiation and proliferation.

  3. provide mechanistic insights into the role of phospho-HLXB9 as a pro-oncogenic factor by interacting with a survival factor and by promoting the oncogenic c-Met pathway

  4. NKX2-2 and MNX1 are etiological genes for neonatal diabetes.

  5. Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas)

  6. Hlxb9 expression is increased in mouse islet tumor.

  7. we developed recombinant lentiviral vectors carrying motor neuron specific regulatory sequences derived from the promoter of homeobox gene Hb9

  8. Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of Ptf1a and is regulated by a distant enhancer element.

  9. This study suggested that Hb9 interneurons are part of the sensorimotor circuitry that regulates the pattern of locomotor rhythms in the isolated cord.

  10. the molecular pathways regulating Hb9 expression are evolutionarily conserved, and that MN-specific gene expression may be directed and achieved using a small 125-bp 5' enhancer

  11. Hb9+ interneurons exhibit strong postinhibitory rebound and demonstrate pronounced membrane potential oscillations in response to chemical stimuli that induce locomotor activity.

  12. Hb9 interneurons are both endogenous bursters and rhythmically active within a heterogeneous electrotonically coupled network

  13. Hlxb9 and Tcfap2b were identified as genes whose expression was elevated in the ZPA compared to the rest of the developing limb bud.

Zebrafish Motor Neuron and Pancreas Homeobox 1 (MNX1) interaction partners

  1. loss of Pax6b or Hb9 independently results in the loss of insulin expression, the data reveal a novel cross-talk between the two essential regulators of early beta-cell differentiation.

  2. These data confirm our previous findings that Mnx1 is important for beta cell fates both in dorsal and ventral bud-derived beta cells.

  3. This study demonistrated that Zebrafish Mnx proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics.

  4. Data suggest that Mnx1 functions to promote beta and suppress alpha cell fates in the developing pancreas.

  5. Essential for differentiation of the insulin-producing beta-cells but not morphogenesis of pancreas.

MNX1 Antigen Profile

Protein Summary

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MNX1

  • motor neuron and pancreas homeobox 1 (MNX1) antibody
  • motor neuron homeobox transcription factor (mnx1) antibody
  • motor neuron and pancreas homeobox 1 (Mnx1) antibody
  • motor neuron and pancreas homeobox 1 (mnx1) antibody
  • HB9 antibody
  • hlxb9 antibody
  • HOXHB9 antibody
  • MNR2 antibody
  • SCRA1 antibody
  • zgc:112174 antibody

Protein level used designations for MNX1

motor neuron and pancreas homeobox 1 , extra-extra-like , motor neuron homeobox transcription factor , homeobox HB9 , homeobox protein HB9 , motor neuron and pancreas homeobox protein 1 , homeobox gene HB9 , uncharacterized protein LOC682076 , homeo box HB9 , Hb9

GENE ID SPECIES
789765 Bos taurus
100303525 Saccoglossus kowalevskii
3110 Homo sapiens
15285 Mus musculus
482821 Canis lupus familiaris
682076 Rattus norvegicus
395768 Gallus gallus
405399 Danio rerio
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