anti-Motor Neuron and Pancreas Homeobox 1 (MNX1) Antibodies

Human Motor Neuron and Pancreas Homeobox 1 (MNX1) interaction partners

1. Pathogenic variants in MNX1 were detected in 28% of all CS cases and 25% of sporadic cases. The clinical phenotype was variable in patients with and without pathogenic variants; no significant genotype-phenotype correlation was observed.

2. Findings identify RGS12 (show RGS12 Antibodies) as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT (show AKT1 Antibodies) and MNX1, establishing a novel oncogenic axis in this disparate disease setting.

3. MNX1 as a novel targetable oncogene (show RAB1A Antibodies) increased in African-American (AA) prostate cancer that is associated with aggressive disease.

4. Findings demonstrated for the first time that lncRNA MNX1-AS1 (show PTGDR Antibodies) functions as an oncogene (show RAB1A Antibodies) in ovarian cancer.

5. The results illustrated miR (show MLXIP Antibodies)-200a and miR (show MLXIP Antibodies)-141 could inhibit the expression of Hlxb9 by binding to its mRNA 3'UTR (show UTS2R Antibodies). Furthermore, the expression of miR (show MLXIP Antibodies)-200a and miR (show MLXIP Antibodies)-141 was almost reciprocal to that of Hlxb9. Overexpression of miR (show MLXIP Antibodies)-200a and miR (show MLXIP Antibodies)-141 downregulated the expression of pancreatic progenitor cell markers Hlxb9

6. The nuclear positioning of the HLXB9 gene was monitored at different stages.

7. study reports the results of MNX1 mutational screening in a series of 28 cases suspected having Currarino Syndrome and characterization of 10 novel mutations

8. NKX2-2 (show Nkx2-2 Antibodies) and MNX1 are etiological genes for neonatal diabetes.

9. Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas)

10. study describes a Norwegian family with typical Currarino syndrome in which a heterozygous deletion removes the entire MNX1 gene but no other known genes; also report MNX1 mutations in 3other Norwegian families and confirm that the GCC12 repeat (c.373_375[12]) is a normal allelic variant

Mouse (Murine) Motor Neuron and Pancreas Homeobox 1 (MNX1) interaction partners

1. Inactivating Mnx1 in embryonic beta-cells (Mnx1(Deltabeta)) caused beta-to-delta-like (show DLK1 Antibodies) cell transdifferentiation, which was delayed until postnatal stages; findings identify Mnx1 as an important factor in beta-cell differentiation and proliferation.

2. provide mechanistic insights into the role of phospho-HLXB9 as a pro-oncogenic factor by interacting with a survival factor and by promoting the oncogenic c-Met pathway

3. NKX2-2 (show Nkx2-2 Antibodies) and MNX1 are etiological genes for neonatal diabetes.

4. Both pHLXB9 and active GSK-3beta are elevated in beta cells with menin knockdown, in MEN1-associated beta cell tumors (insulinomas)

5. Hlxb9 expression is increased in mouse islet tumor.

6. we developed recombinant lentiviral vectors carrying motor neuron specific regulatory sequences derived from the promoter of homeobox gene Hb9

7. Mnx1, a gene that is absolutely required in pancreas progenitors, is a major direct target of Ptf1a (show PTF1A Antibodies) and is regulated by a distant enhancer element.

8. This study suggested that Hb9 interneurons are part of the sensorimotor circuitry that regulates the pattern of locomotor rhythms in the isolated cord.

9. the molecular pathways regulating Hb9 expression are evolutionarily conserved, and that MN-specific gene expression may be directed and achieved using a small 125-bp 5 (show HSPD1 Antibodies)' enhancer

10. Hb9+ interneurons exhibit strong postinhibitory rebound and demonstrate pronounced membrane potential oscillations in response to chemical stimuli that induce locomotor activity.

Zebrafish Motor Neuron and Pancreas Homeobox 1 (MNX1) interaction partners

1. loss of Pax6b (show PAX6 Antibodies) or Hb9 independently results in the loss of insulin (show INS Antibodies) expression, the data reveal a novel cross-talk between the two essential regulators of early beta-cell differentiation.

2. These data confirm our previous findings that Mnx1 is important for beta cell fates both in dorsal and ventral bud-derived beta cells.

3. This study demonistrated that Zebrafish Mnx (show KRT86 Antibodies) proteins specify one motoneuron subtype and suppress acquisition of interneuron characteristics.

4. Data suggest that Mnx1 functions to promote beta and suppress alpha cell fates in the developing pancreas.

5. Essential for differentiation of the insulin (show INS Antibodies)-producing beta-cells but not morphogenesis of pancreas.