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ovarian BAD-interacting protein\; may inhibit apoptosis [RGD, Feb 2006].. Additionally we are shipping MCL1 Kits (2) and many more products for this protein.
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Authors treated Mcl-1(+/-) heterozygous mice, which have a ~50% reduction in MCL-1 protein in their cells, with a broad range of chemotherapeutic drugs. Monitoring of treated mice revealed that a wide range of chemotherapeutic drugs had no significant effect on the general well-being of Mcl-1(+/-) mice with no overt damage to a broad range of tissues.
analysis of how a hydrophobic staple induces an unanticipated structural rearrangement in Mcl-1 upon binding
Mcl-1 is a disease-specific target of Cdk5 (show CDK5 Antibodies), which associates with Cdk5 (show CDK5 Antibodies) under basal conditions, but is not regulated by it.
These findings elucidate a crucial molecular pathway of B cell selection in the earliest phases of activation by identifying a novel link between B cell receptor affinity and BAFF-R (show TNFRSF13C Antibodies) signaling towards Mcl-1.
Even though the Mcl-1 protein in Mcl1-flox-del homozygous animals is normal, the males were still infertile.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2 (show BCL2 Antibodies), Mcl1, and BCL2A1 (show BCL2A1 Antibodies), rather than by a single anti-apoptotic protein.
This dynamic change in B cell survival mechanisms is unique to Epstein-Barr virus-infected cells and relies on regulation of MCL-1 mitochondrial localization and BFL-1 (show BCL2A1 Antibodies) transcription by the viral EBNA3A (show EBNA-3A Antibodies) protein.
Overexpression of Mcl-1 via the hemopoietic cell specific vavP-Mcl-1 transgene markedly exacerbates and accelerates the lpr (show FAS Antibodies) phenotype. The progressive splenomegaly and lymphadenopathy displayed by lpr (show FAS Antibodies) mice was far more severe in Mcl (show CLEC4D Antibodies)-1tg/lpr (show FAS Antibodies) littermates
Endothelial cell -specific deletion of Mcl1 resulted in a dose-dependent increase in endothelial cell apoptosis in the angiogenic vasculature and a corresponding decline in vessel density.
Our findings indicate that MCL-1 expression is an important biomarker of TEC (show NR4A3 Antibodies) survival
ovarian BAD-interacting protein\; may inhibit apoptosis
bcl-2-related protein EAT/mcl1
, induced myeloid leukemia cell differentiation protein Mcl-1 homolog