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NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. Additionally we are shipping NAT1 Proteins (12) and NAT1 Kits (2) and many more products for this protein.
Showing 10 out of 78 products:
Cow (Bovine) Monoclonal NAT1 Primary Antibody for IF, IP - ABIN968149
Henis-Korenblit, Strumpf, Goldstaub, Kimchi: A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. in Molecular and cellular biology 2000
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Cow (Bovine) Monoclonal NAT1 Primary Antibody for IF, IP - ABIN968148
Yamanaka, Poksay, Arnold, Innerarity: A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. in Genes & development 1997
Show all 3 Pubmed References
Human Polyclonal NAT1 Primary Antibody for ELISA - ABIN450064
Smelt, Upton, Adjaye, Payton, Boukouvala, Johnson, Mardon, Sim: Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos. in Human molecular genetics 2000
identified a novel endogenous role for human NAT1 (show EIF4G2 Antibodies) that might explain some of its effects in cancer cell growth and survival
N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.
The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (show MTHFR Antibodies) c.677C>T p.A222V(rs1801133), TP53 (show TP53 Antibodies) c.215C>G p.R72P (rs1042522), NQO1 (show NQO1 Antibodies) c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 Antibodies) alleles imputed as fast acetylator genotypes. [meta-analysis]
NAT1 (show EIF4G2 Antibodies) genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.
NAT1 (show EIF4G2 Antibodies) genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.
NAT1 (show EIF4G2 Antibodies) has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.
We report that miR (show MLXIP Antibodies)-1290 directly targets the NAT1 (show EIF4G2 Antibodies) 3'-UTR (show UTS2R Antibodies) and that NAT1 (show EIF4G2 Antibodies) protein expression is correlated with improved OS of breast cancer patients.
Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine
Candidate gene NAT1 (show EIF4G2 Antibodies) were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status.
Data suggest that NAT1 (show EIF4G2 Antibodies)/NAT2 (show SLC38A1 Antibodies) participate in biotransformation of many aromatic/heterocyclic amines; molecular models have been developed regarding acetylation mechanism, active site structure, and substrate/inhibitor-binding specificity. [REVIEW]
This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.
our results suggest that Nat1 (show EIF4G2 Antibodies) deficiency results in mitochondrial dysfunction, which may constitute a mechanistic link between this gene and insulin (show INS Antibodies) resistance .
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 (show NAT2 Antibodies) defined by substrate specificity and inhibitor binding.(
In adipocytes, Nat1 (show EIF4G2 Antibodies) silencing lowered insulin (show INS Antibodies)-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1 (show EIF4G2 Antibodies)(-) mice had high fasting blood glucose, insulin (show INS Antibodies), and triglycerides and low insulin (show INS Antibodies) sensitivity.
Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT (show BRD2 Antibodies) gene expression is species dependent
NAT1 (show EIF4G2 Antibodies) affects cell growth and morphology
Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.
Results suggest that peroxynitrite-dependent inactivation of NAT1 (show EIF4G2 Antibodies) and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.
N-acetyltransferase type 1
, arylamide acetylase 1
, arylamine N-acetyltransferase 1
, monomorphic arylamine N-acetyltransferase
, N(alpha)-acetyltransferase 15, NatA auxiliary subunit
, N-acetyl transferase 1, liver, blood
, N-acetyltransferase (arylamine N-acetyltransferase)
, N-acetyltransferase 1 (arylamine N-acetyltransferase)
, Arylamide acetylase 1
, Monomorphic arylamine N-acetyltransferase
, NAT1 9
, acetyltransferase AT-I
, arylamine acetyltransferase