NAT1 antibody (AA 909-1025)

Catalog No. ABIN7168283

Product Details anti-NAT1 Antibody

Target: NAT1 (N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1))

Binding Specificity: AA 909-1025

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human RNA cytidine acetyltransferase protein (909-1025AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NAT1

Target: NAT1 (N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1))

Alternative Name: NAT1 (NAT1 Products)

Synonyms: AAC1 antibody, MNAT antibody, NAT-1 antibody, NATI antibody, Nat-1 antibody, Nat antibody, NAT1 antibody, AT-I antibody, N-acetyltransferase 1 antibody, N-acetyl transferase 1 antibody, N-acetyltransferase 1 (arylamine N-acetyltransferase) antibody, arylamine N-acetyltransferase 1-like antibody, NAT1 antibody, Nat1 antibody, LOC101095575 antibody

Background:

Background: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).

Aliases: ALP antibody, DKFZp434C116 antibody, FLJ10774 antibody, FLJ12179 antibody, FLJ23850 antibody, hALP antibody, KIAA1709 antibody, N acetyltransferase 10 antibody, N acetyltransferase 10 GCN5 related antibody, N acetyltransferase like antibody, N acetyltransferase like protein antibody, N-acetyltransferase 10 antibody, NAT10 antibody, NAT10_HUMAN antibody, NET43 antibody

UniProt: Q9H0A0