N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) Proteins (NAT2)

NAT2 encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Additionally we are shipping NAT2 Antibodies (63) and NAT2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAT2 116632 P50298
NAT2 10 P11245
NAT2 17961 P50295
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Top NAT2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
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Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
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Yeast Golden Syrian Hamster His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
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Yeast Rhesus Monkey His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details

NAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
,
Mouse (Murine)

More Proteins for N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) Interaction Partners

Human N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. The present study demonstrated no association between NAT2 genotype and drug-induced hepatotoxicity in the north Indian patients with tuberculosis.

  2. CYP3A4 (show CYP3A4 Proteins) expression and N-acetyl transferase 2 acetylator phenotype can better identify the patients with higher risk of adverse reactions and can facilitate the improvement of personalized clonazepam therapy and withdrawal regimen.

  3. NAT2 genotypes are associated with N-acetylation phenotype variation.

  4. NAT2 acetylator genotype has an important role in 4, 4'-methylene bis (show BAG3 Proteins) (2-chloroaniline) metabolism and suggest that risk assessments related to 4, 4'-methylene bis (show BAG3 Proteins) (2-chloroaniline) exposures consider accounting for NAT2 acetylator phenotype in the analysis

  5. Review/Meta-analysis: NAT2 slow acetylation genotype is associated with an increased bladder cancer risk in Chinese individuals.

  6. six selected NAT2 exonic single nucleotide polymorphisms were genotyped in an independent case-control sample of a Northern Chinese Han population to verify the possible association between NAT2 and schizophrenia. Three (rs1801280T/341C, rs1799930/G590A, and rs1208/A803G) of the six single nucleotide polymorphisms showed significant allele frequency differences between the case and the control groups.

  7. Our findings suggested that NAT2 gene polymorphism rs1799931 was associated with decreased risk of acute myeloid leukemia (show BCL11A Proteins) and was likely to be a protective factor against acute myeloid leukemia (show BCL11A Proteins) development.

  8. Study reestablished the association between NAT2 SA and isoniazid-induced liver injury in a Singaporean population and demonstrated its clinical validity in prediction of isoniazid-induced liver injury.

  9. In non-syndromic cleft lip with or without cleft palate, we found a significant association between the EGF61 (rs4444903) and NSCL (show NHLH1 Proteins)/P (P = .01) genes. Conversely, NAT2 (rs1799929) was not significantly different between the cases and the control group

  10. 182 Hungarian bladder cancer cases and 78 cancer-free controls were investigated. It was not possible to establish a particular impact of NAT2*6A and *7B genotypes (15 cases, 8%, 5 controls, 7%). GSTT1 (show GSTT1 Proteins) exerted no marked influence on bladder cancer (negative 21% cases vs. 22% controls). The portion of GSTM1 (show GSTM1 Proteins) negative bladder cancer patients was increased (63% cases vs. 54% controls).

Mouse (Murine) N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 (show SLC38A2 Proteins) in the trophectoderm and placental lineages.

  2. This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.

  3. Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells

  4. We found that MeCP2 acts as a microglia-specific transcriptional repressor of

  5. It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa.

  6. GlnT would promote both proliferation and neuronal differentiation through a mechanism relevant to the upregulation of particular proneural genes in undifferentiated P19 cells.

  7. Inner hair cells express glutamine transporter SLC38A1.

  8. Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation.

  9. In this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine transporters Snat3 (Slc38a3) and Snat1 (Slc38a1) was investigated in the mouse brain microvasculature.

  10. Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 (show EIF4G2 Proteins) gene expression with certain developmental malformations and cancers.

Rhesus Monkey N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. The study is the first to thoroughly characterize the properties of a polymorphic NAT isoenzyme in a non-human primate model.

NAT2 Protein Profile

Protein Summary

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).

Gene names and symbols associated with NAT2

  • N-acetyltransferase 2 (Nat2)
  • N-acetyltransferase 2 (NAT2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (Nat2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2)
  • solute carrier family 38, member 1 (Slc38a1)
  • AA408026 protein
  • AA409865 protein
  • AAC2 protein
  • AL022800 protein
  • AT-2 protein
  • AT-B/AT-II protein
  • AT-II protein
  • AT2 protein
  • AU015942 protein
  • AV377607 protein
  • NAT protein
  • NAT-2 protein
  • NAT2 protein
  • Nat2a protein
  • PNAT protein

Protein level used designations for NAT2

AT-2 , N-Acetyltransferase-2 (arylamine N-acetyltransferase) , N-acetyltransferase 2 (arylamine N-acetyltransferase) , N-acetyltransferase type 2 , NAT-2 , arylamide acetylase 2 , arylamine N-acetyltransferase 2 , N-acetyl transferase 2 , PNAT , lambda R-1 , polymorphic arylamine N-acetyltransferase , Arylamide acetylase 2 , NAT2 15 , Polymorphic arylamine N-acetyltransferase , acetyltransferase , arylamine N-acetyltransferase-2 , MNat2 , N-system amino acid transporter 2 , amino acid transporter A1 , sodium-coupled neutral amino acid transporter 1 , system A amino acid transporter 1 , system N amino acid transporter 1

GENE ID SPECIES
116632 Rattus norvegicus
10 Homo sapiens
17961 Mus musculus
100008974 Oryctolagus cuniculus
101840555 Mesocricetus auratus
704357 Macaca mulatta
105727 Mus musculus
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