N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) Proteins (NAT2)

NAT2 encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Additionally we are shipping NAT2 Antibodies (68) and NAT2 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAT2 10 P11245
NAT2 17961 P50295
NAT2 116632 P50298
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Top NAT2 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details
Yeast Golden Syrian Hamster His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details
Yeast Rhesus Monkey His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details

NAT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) Interaction Partners

Human N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. NAT2 (show SLC38A1 Proteins) polymorphism is not associated with passive smoking associated breast cancer risk.

  2. NAT2 (show SLC38A1 Proteins) role in the metabolic detoxification of heterocyclic aromatic amines

  3. hydralazine efficacy and safety could be improved by NAT2 (show SLC38A1 Proteins) genotype-dependent dosing strategies

  4. Studied the association between N-acetyl transferase 2 (NAT2)genetic polymorphisms, environmental factors and risk factors in colon or rectal cancer.

  5. There were significant differences in NAT2 (show SLC38A1 Proteins)(rs1799929, rs1799930) genotype or allele frequencies between the infertile and fertile groups and synergy effects of GSTP1 (show GSTP1 Proteins) and NAT2 (show SLC38A1 Proteins) polymorphisms might lead to significant increase of infertility risk.

  6. The increased risk of prostate cancer was observed among individuals with the NAT2 (show SLC38A1 Proteins) slow acetylator phenotype

  7. Genotyping of TB patients from south India for NAT2 gene polymorphism revealed that 58 per cent of the study population comprised slow acetylators. Two-hour INH concentrations differed significantly among the three genotypes.

  8. Slow NAT2 (show SLC38A1 Proteins) acetylators demonstrated a significant association with risk of anti-tuberculosis drug-induced liver injury in Thai patients.

  9. The present study demonstrated no association between NAT2 (show SLC38A1 Proteins) genotype and drug-induced hepatotoxicity in the north Indian patients with tuberculosis.

  10. CYP3A4 (show CYP3A4 Proteins) expression and N-acetyl transferase 2 acetylator phenotype can better identify the patients with higher risk of adverse reactions and can facilitate the improvement of personalized clonazepam therapy and withdrawal regimen.

Mouse (Murine) N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.

  2. It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa.

  3. Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation.

  4. Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 (show EIF4G2 Proteins) gene expression with certain developmental malformations and cancers.

  5. Nat2 knockout mouse line demonstrates that different Nat2 isoforms have distinct functions with no compensatory expression, in Nat2 knockout animals, of the other isoforms.

  6. Variation in capacity for acetylation of 4ABP and PABA resulting from endogenous murine NAT2 alleles is insufficient to affect 4ABP genotoxicity in liver.

  7. Results suggest that peroxynitrite-dependent inactivation of NAT1 (show EIF4G2 Proteins) and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.

  8. These ocular phenotypes and their association with Nat2 genotype indicate that the Nat2 locus may be responsible for the previously described microphthalmic Cat4 (show SLC7A4 Proteins) phenotype.

  9. study reports the detailed expression of the Nat2 gene and encoded protein in mouse embryos

  10. Mouse N-acetyltransferase-2 was produced as a recombinant protein and found to have a substrate specificity profile similar to human N-acetyltransferase type 1 (show NAT1 Proteins).

Rhesus Monkey N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) (NAT2) interaction partners

  1. The study is the first to thoroughly characterize the properties of a polymorphic NAT isoenzyme in a non-human primate model.

NAT2 Protein Profile

Protein Summary

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).

Gene names and symbols associated with NAT2

  • N-acetyltransferase 2 (NAT2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2)
  • N-acetyltransferase 2 (arylamine N-acetyltransferase) (Nat2)
  • N-acetyltransferase 2 (Nat2)
  • AAC2 protein
  • AT-2 protein
  • AT-B/AT-II protein
  • AT-II protein
  • AT2 protein
  • AV377607 protein
  • NAT protein
  • NAT-2 protein
  • Nat2a protein
  • PNAT protein

Protein level used designations for NAT2

N-acetyltransferase type 2 , arylamide acetylase 2 , arylamine N-acetyltransferase 2 , PNAT , lambda R-1 , polymorphic arylamine N-acetyltransferase , N-acetyl transferase 2 , NAT-2 , AT-2 , N-Acetyltransferase-2 (arylamine N-acetyltransferase) , N-acetyltransferase 2 (arylamine N-acetyltransferase) , Arylamide acetylase 2 , NAT2 15 , Polymorphic arylamine N-acetyltransferase , acetyltransferase , arylamine N-acetyltransferase-2

GENE ID SPECIES
10 Homo sapiens
100008974 Oryctolagus cuniculus
17961 Mus musculus
116632 Rattus norvegicus
704357 Macaca mulatta
101840555 Mesocricetus auratus
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