N-Ethylmaleimide-Sensitive Factor Proteins (NSF)

Required for vesicle-mediated transport. Additionally we are shipping NSF Antibodies (116) and NSF Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NSF 4905 P46459
NSF 18195 P46460
NSF 60355 Q9QUL6
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Top NSF Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
Escherichia coli (E. coli) Rat His tag 100 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human NSF Protein. 100 μg 11 to 18 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Escherichia coli (E. coli) Rat Un-conjugated   50 μg 9 to 11 Days

NSF Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus) ,

More Proteins for N-Ethylmaleimide-Sensitive Factor (NSF) Interaction Partners

Human N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. A large copy number variant (CNV) that encompasses part of the NSF gene contributes to cocaine dependence.

  2. NSF deficiency in HeLa cells barely affected cell viability, anterograde trafficking of vesicular stomatitis virus glycoprotein G and transferrin endocytosis.

  3. a processive helicase-like mechanism for NSF in which approximately 1 residue is unwound for every hydrolyzed ATP molecule.

  4. Single and multiple-marker analyses revealed a strong association between cocaine dependence and the NSF gene.

  5. Knockdown of TRX1 increases the level of S-nitrosylated NSF, prolongs the inhibition of exocytosis, and suppresses leukocyte

  6. NSF independent fusion of Salmonella-containing late phagosomes with early endosomes.

  7. analysis of human NSF possible binding mode to GABARAP and GATE-16

  8. binding of NSF to GluR2-containing AMPARs in stabilizing these receptors in the synaptic membrane and impeding their regulated endocytosis.

  9. role of interaction with GluR2 in regulation of AMPA receptors by brain-derived neurotrophic factor

  10. Nitric oxide regulates exocytosis by S-nitrosylation of NSF.

  11. Expressing a biochemically defined NSF mutant that lacks ATPase activity results in a dramatic inhibition of stimulated mast cell exocytosis.

  12. NSF dissociates the VAMP-2.SNAP-25.syntaxin 13 complex, but has no effect on the Hrs-containing complex.

  13. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein

  14. dual regulation on hbeta2AR trafficking and signaling by NSF through direct binding to cargo receptor and its ATPase activity.

  15. Data show that NSF is an inclusion body component in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.

  16. Data show that phosphorylation of N-ethylmaleimide-sensitive factor on tyrosine residues prevents its SNARE complex dissociation activity and establish a role for PTP1B in the modulation of the membrane fusion machinery.

Mouse (Murine) N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. Munc13-1 and Munc18-1, but not CAPS-1/2, stabilize primed synaptic vesicles by preventing NSF-dependent de-priming.

  2. NSF may have a role in vascular instability in gram-positive lung infections

  3. that mutant LRRK2 may impair synaptic vesicle dynamics via aberrant phosphorylation of N-ethylmaleimide sensitive fusion

  4. identify conserved sequences in the 3'UTR of NSF as miR-33 responsive elements and show that Nsf is specifically recruited to the RNA-induced silencing complex following induction of miR-33

  5. Arr1 and NSF interaction are necessary for both maintenance and modulation of normal photoreceptor synaptic regulation and NSF-RP2 interaction may play an important role in membrane protein trafficking in the photoreceptor.

  6. These findings identify new roles for N-ethylmaleimide-sensitive factor and protein kinase C epsilon in regulating synaptic inhibition through downregulation of GABA(A) receptors

  7. interaction of AMPA receptors with N-ethylmaleimide-sensitive factor plays a critical role in incorporation of AMPA receptors into synapses and for their subsequent removal during cerebellar long term depression

  8. PICK1 and NSF dynamically regulate the synaptic delivery of GluR2-containing receptors during CARP and thus regulate the calcium permeability of AMPA receptors at excitatory synapses.

  9. H(2)O(2) regulates exocytosis by inhibiting N-ethylmaleimide sensitive factor (NSF), a protein that regulates membrane fusion events necessary for exocytosis.

  10. important role for NSF activity in regulating the cell surface stability of GABA(A) receptors.

  11. dual regulation on hbeta2AR trafficking and signaling by NSF through direct binding to cargo receptor and its ATPase activity.

  12. These results indicate that phosphorylation of GluR2 S880 and NSF and PICK1 binding to GluR2 dynamically regulate GluR2 recycling.

  13. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide sensitive factor

Cow (Bovine) N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. Report depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole.

Xenopus laevis N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. NSF- and SNARE-mediated membrane fusion events are essential steps during Nuclear envelope formation downstream of Nup107 recruitment, and upstream of membrane flattening and completion of nuclear pore complex assembly.

Zebrafish N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. Molecular analysis of ndrg4 mutants shows that expression of snap25 and nsf are sharply decreased, revealing a role of ndrg4 in controlling vesicle exocytosis. This uncovers a previously unknown function of ndrg4 in regulating vesicle docking and nodes of Ranvier organization, at least through its ability to finely tune the expression of the t-SNARE/NSF machinery.

  2. results establish a role for Nsf in the maintenance of synaptic contacts between hair cells and afferent neurons, mediated in part via the secretion of trophic signaling factors

  3. Nsf is essential in the formation of the nodes of Ranvier in the vertebrate nervous system.

  4. Activation of PKCgamma is necessary for the activity-dependent trafficking of AMPARs in embryonic zebrafish and is NMDA and SNARE-dependent and requires AMPARs to associate with both NSF and PICK1.

  5. This study analyses of nsf mutant zebrafish reveal an unexpected role for NSF in hypothalamic development, with mutant 5 days post-fertilization larvae exhibiting a stage-dependent loss of neuroendocrine transcripts.

Arabidopsis thaliana N-Ethylmaleimide-Sensitive Factor (NSF) interaction partners

  1. The mutant phenotype to the missense mutation D374N in the NSF gene, encoding the N-ethylmaleimide-sensitive factor, was linked a key component of membrane fusion.

NSF Protein Profile

Protein Summary

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity).

Gene names and symbols associated with NSF

  • N-ethylmaleimide sensitive factor, vesicle fusing ATPase (NSF)
  • N-ethylmaleimide sensitive fusion protein (Nsf)
  • N-ethylmaleimide sensitive factor, vesicle fusing ATPase (Nsf)
  • N-ethylmaleimide-sensitive factor (NSF)
  • N-ethylmaleimide sensitive factor (nsf)
  • N-ethylmaleimide-sensitive factor (BBOV_II007200)
  • N-ethylmaleimide-sensitive fusion protein, putative (TGME49_318510)
  • N-ethylmaleimide sensitive factor L homeolog (nsf.L)
  • vesicle-fusing ATPase (LOC100180685)
  • vesicle-fusing ATPase (LOC9310886)
  • N-ethylmaleimide-sensitive factor a (nsfa)
  • AAA-type ATPase family protein (NSF)
  • 18.m06598 protein
  • AI316878 protein
  • AU020090 protein
  • AU067812 protein
  • N-ethylmaleimide sensitive factor protein
  • NEM-sensitive fusion protein protein
  • nsf protein
  • si:bz18k17.1 protein
  • SKD2 protein
  • T1J1.4 protein
  • T1J1_4 protein
  • wu:fj33g11 protein

Protein level used designations for NSF

N-ethylmaleimide-sensitive factor-like protein , N-ethylmaleimide-sensitive fusion protein , NEM-sensitive fusion protein , vesicle-fusing ATPase , vesicular-fusion protein NSF , N-ethylmaleimide sensitive factor , suppressor of K(+) transport growth defect 2 , N-ethylmaleimide sensitive fusion protein , N-ethylmaleimide-sensitive factor , vesicle-fusing ATPase-like , Vesicle-fusing ATPase , Vesicular-fusion protein NSF

4905 Homo sapiens
18195 Mus musculus
60355 Rattus norvegicus
373397 Strongylocentrotus purpuratus
419972 Gallus gallus
454819 Pan troglodytes
490921 Canis lupus familiaris
504457 Bos taurus
780249 Xenopus (Silurana) tropicalis
5478472 Babesia bovis T2Bo
7901210 Toxoplasma gondii ME49
100024726 Monodelphis domestica
100049722 Xenopus laevis
100063690 Equus caballus
100174078 Pongo abelii
100180685 Ciona intestinalis
100472215 Ailuropoda melanoleuca
779070 Xenopus laevis
9310886 Arabidopsis lyrata subsp. lyrata
368483 Danio rerio
100624659 Sus scrofa
825830 Arabidopsis thaliana
101120344 Ovis aries
100734887 Cavia porcellus
100770898 Cricetulus griseus
715297 Macaca mulatta
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