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NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping N-Myc Downstream Regulated 1 Antibodies (171) and N-Myc Downstream Regulated 1 Proteins (16) and many more products for this protein.
Showing 4 out of 9 products:
Our experiments revealed that long-term (24 h), but not short-term hypoxia led to the induction of NDRG1 expression in human glioma cell lines. NDRG1 expression was found to correlate with the protein expression of HIF-1alpha (show HIF1A ELISA Kits), SP1 (show PSG1 ELISA Kits), CEBPalpha, YB-1 (show YBX1 ELISA Kits) and Smad7 (show SMAD7 ELISA Kits)
Data show that LSD1 affects motility and invasiveness of neuroblastoma cells by modulating the transcription of the metastasis suppressor NDRG1. Mechanistically, results found that LSD1 co-localizes with MYCN at the promoter region of the NDRG1 gene and inhibits its expression.
Compared with the normal term pregnancies, the expression of both NDRG1 mRNA and protein were significantly high in placentas from preeclampsia, and the expression of NDRG1 in early-onset preeclampsia was higher than that in late-onset preeclampsia.
we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer cells
strong NDRG1 expression in ciliated epithelial cells in nasal tissues sampled from patients with chronic rhinosinusitis. NDRG1 gene knockdown decreased the transepithelial electrical resistance and increased the dextran permeability. NDRG1 knockdown disrupted tight junctions of airway epithelial cells. NDRG1 knockdown significantly decreased only claudin-9 (show CLDN9 ELISA Kits) expression, but did not decrease other claudin family molecules.
Study elucidates a mechanism of NDRG1-regulated Wnt (show WNT2 ELISA Kits) pathway activation and EMT (show ITK ELISA Kits) via affecting TLE2 (show TLE2 ELISA Kits) and beta-catenin (show CTNNB1 ELISA Kits) expression in esophageal cancer cells.
NDRG1 prevented the degradation of c-Myc (show MYC ELISA Kits) through Skp2-mediated ubiquitination in tumor cells. NDRG1 directly interacted with Skp2, and decreased phosphorylation of Skp2 through inactivation of CDK2 (show CDK2 ELISA Kits).
Data suggest that NDRG1 attenuates oncogenic signaling by inhibiting formation of EGFR (show EGFR ELISA Kits)/HER2 (show ERBB2 ELISA Kits) and HER2 (show ERBB2 ELISA Kits)/HER3 (show ERBB3 ELISA Kits) heterodimers and by down-regulating EGFR (show EGFR ELISA Kits) via a mechanism involving its degradation. (NDRG1 = N-myc downstream regulated gene 1 protein; EGFR (show EGFR ELISA Kits) = epidermal growth factor receptor (show EGFR ELISA Kits); HER = human epidermal growth factor receptor (show EGFR ELISA Kits)) [REVIEW]
NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors
NDRG1 overexpression leads to reduced tumor growth and angiogenesis in experimental glioma via upregulation of TNFSF15. In NDRG1 overexpressing glioma antiangiogenic treatment does not yield a therapeutic response.
NDR1 kinase, activated by the Rap1 (show TERF2IP ELISA Kits) signaling cascade through RAPL and Mst1 (show MST1 ELISA Kits)/Mst2, associated with and recruited kindlin-3 (show FERMT3 ELISA Kits) to the immunological synapses, which was required for high-affinity LFA-1 (show ITGAL ELISA Kits)/ICAM-1 (show ICAM1 ELISA Kits) binding.
Snell, GHKRO, and PAPPA (show PAPPA ELISA Kits)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (show MGMT ELISA Kits)) and N-myc downstream-regulated gene 1 (NDRG1).
NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.
Using double knockout of NDR1 and 2 shows that NDRs acted downstream of MST1 (show MST1 ELISA Kits) to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.
Ndrg1 is phosphorylated and degraded by CD28 (show CD28 ELISA Kits) signalling in a proteasome-dependent manner.
Ndr1/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR kinases are critically required during the early phase of organogenesis
Rassf5 and Ndr1 or Ndr2 kinases regulate neuronal polarity through Par3 (show F2RL2 ELISA Kits) phosphorylation.
NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner
early growth response 1 (show EGR1 ELISA Kits), a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2 (show PKD2 ELISA Kits).
NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.
SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.
The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.
Sequence analysis and mass spectrometry suggest that NDR1 is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI (show GPI ELISA Kits)) anchor.
demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae
Mutations in NDR1 abolished the enhanced resistance of dnd mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
N-myc downstream-regulated gene 1 protein
, differentiation-related gene 1 protein
, nickel-specific induction protein Cap43
, protein NDRG1
, protein regulated by oxygen-1
, reducing agents and tunicamycin-responsive protein
, N-myc downstream regulated 1
, protein Ndr1
, N-myc downstream regulated gene 1
, protein NDRG1-B
, protein NDRG1-like