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NKX2-6 encodes a homeobox-containing protein that belongs to the NK-2 homeobox family.
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Results suggest that XNkx2-10, like XNkx2-3 and XNkx2-5, is necessary for normal Xenopus heart development.
This study firstly links NKX2.6 loss-of-function mutation with increased susceptibility to isolated VSD.
Data associated genetically defective NK2 homeobox 6 (NKX2-6) with enhanced susceptibility to atrial fibrillation (AF).
Heterozygous mutations in Nkx2.6, p.V176M and p.K177X, were identified in 2 unrelated patients, one with tetralogy of Fallot and one with double outlet of right ventricle and ventricular septal defect. Increased vulnerability to TOF or DORV is discussed.
NKX2-6 plays a role in human cardiogenesis.
weakly activates transcription of a Cx40 (show GJA5 Proteins) promoter, may have role in heart development
NKX2.5 (show NKX2-5 Proteins)/NKX2.6 mutations are not a common cause of isolated type 1 truncus arteriosus in a small cohort of multiethnic cases.
This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. This protein is a vertebrate homolog of Drosophila homeobox-containing protein called 'tinman', which has been shown to be essential for development of the heart-like dorsal vessel. In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. Mutations in this gene are associated with persistent truncus arteriosus.
NK2 transcription factor related, locus 6
, homeodomain protein XNkx2-10
, homeobox protein Nkx-2.6
, homeobox protein Nkx-2.8
, NK2 transcription factor related, locus 6 (Drosophila)
, homeobox protein NK2 homolog F
, homeobox protein NKX2.6
, tinman paralog
, Drosophila NK2 transcription factor related, locus 6
, homeobox protein NK-2 homolog F