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The NKX family of homeodomain proteins controls numerous developmental processes.
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The expression level of NKX6.3 is involved in regulation of gastric cancer progression and expression of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) and Rho-GTPase (show RACGAP1 ELISA Kits) pathway-related genes in clinical samples.
Suggest that NKX6.3 might function as a master regulator of gastric differentiation by affecting SOX2 (show SOX2 ELISA Kits) and CDX2 (show CDX2 ELISA Kits) expression and the NKX6.3 inactivation may result in intestinal metaplasia in gastric epithelial cells.
Data suggest that NK6 homeobox 3 (NKX6.3) may control the fate of gastric mucosal cells and function as a gastric tumor suppressor.
Thus, cross-antagonism between Nkx6 and Ptf1a (show PTF1A ELISA Kits) in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development.
Nkx6.3 shows a remarkably selective expression in a subpopulation of differentiating V2 neurons at caudal (show CAD ELISA Kits) hindbrain levels.
Nkx6.3 transcripts localize in the epithelium of the most distal stomach region, the antrum and pylorus; expression in the adult intestine is lower and confined to the proximal duodenum.
Nkx6.3 function is dispensable for CNS development and lead to the proposal that absence of overt defects is due to functional compensation from a related homeodomain transcription factor.
Nkx6.1 (show NKX6-1 ELISA Kits) and Nkx6.2 share overlapping expression domains in the ventral neural tube at neurula stages and later in the ventral part of developing hindbrain and spinal cord. Nkx6.3 is detected in the non-neural ectoderm.
The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006
NK6 homeobox 3
, NK6 transcription factor related, locus 3
, homeobox protein Nkx-6.3
, transcription factor Nkx6.3
, NK6 transcription factor related locus 3