NLR Family, Pyrin Domain Containing 1B Proteins (NLRP1B)

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation.

list all proteins Gene Name GeneID UniProt
NLRP1B 637515 A1Z198
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
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NLRP1B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

More Proteins for NLR Family, Pyrin Domain Containing 1B (NLRP1B) Interaction Partners

Mouse (Murine) NLR Family, Pyrin Domain Containing 1B (NLRP1B) interaction partners

  1. Lethal factor directly cleaves NLRP1B, inducing the N-end rule-mediated degradation of the NLRP1B N terminus and freeing the NLRP1B C terminus to activate caspase-1.

  2. NLRP1B senses cellular infection by distinct invasive pathogens.

  3. ASC-driven caspase-1 autoprocessing and speck formation are dispensable for the activation of caspase-1 and the NLRP1b inflammasome.

  4. Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.

  5. Data suggest that caspase-1 autoproteolysis in NLR family pyrin domain containing 1b (NLRP1b) and NLR family pyrin domain containing 3 (NLRP3) inflammasome function may have implications for pathogen recognition and response.

  6. NLRP1 functions primarily as a sensor of protease activity and thus could conceivably detect a broader spectrum of pathogens than just B. anthracis.

  7. macrophages from some inbred mouse strains simultaneously express different splice variants of Nlrp1b

  8. Mouse Nlrp1b proteins are also cleaved by lethal factor.

  9. Proteolysis of Nlrp1b was shown to be required for the assembly of a functional inflammasome

  10. data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1b(S), caspase-1, and IL-1beta in countering anthrax infection.

  11. an extremely polymorphic gene in this locus, Nalp1b, is the primary mediator of mouse macrophage susceptibility to LeTx (lethal toxin)

  12. The authors demonstrate that transfection of human fibroblasts with plasmids encoding murine Nlrp1b and procaspase-1 was sufficient to confer susceptibility to lethal toxin-mediated death on the cells.

  13. animals expressing a lethal toxin (LT)-sensitive allele of Nlrp1b showed an early inflammatory response to LT and increased resistance to infection by B. anthracis

NLR Family, Pyrin Domain Containing 1B (NLRP1B) Protein Profile

Protein Summary

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Might be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532). {ECO:0000250|UniProtKB:Q2LKW6, ECO:0000269|PubMed:16429160, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:21170303, ECO:0000269|PubMed:24492532}.

Gene names and symbols associated with NLRP1B

  • NLR family, pyrin domain containing 1B (Nlrp1b)
  • Nalp1b protein

Protein level used designations for NLRP1B

NACHT-, LRR-, and PYD-containing protein 1 paralog b , NLR family, pyrin domain containing 1B , NLR family, pyrin domain containing 1B, CAST/EiJ specific, allele 3 , NLR family, pyrin domain containing 1B, PWK/PhJ specific, allele 1 , OTTMUSCASG00059402 , OTTMUSPWKG00059388

GENE ID SPECIES
637515 Mus musculus
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