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NLR Family, Pyrin Domain Containing 1B Proteins

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation.

5 results:

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1177) protein (His tag) Protein

NLRP1B Origin: Mouse Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3130666
$14,592.92
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 70 Business Days

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-906) protein (His tag) Protein

NLRP1B Origin: Mouse Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3134939
$14,592.92
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 70 Business Days

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1172) protein (His tag) Protein

NLRP1B Origin: Mouse Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3134940
$14,592.92
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 70 Business Days

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1233) protein (His tag) Protein

NLRP1B Origin: Mouse Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3134941
$14,592.92
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 70 Business Days

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1196) protein (His tag) Protein

NLRP1B Origin: Mouse Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3134880
$14,592.92
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 70 Business Days
  • Type Protein
    • Protein
  • Target NLR Family, Pyrin Domain Containing 1B (NLRP1B)
    • NLR Family, Pyrin Domain Containing 1B (NLRP1B)
    • Hemagglutinin (HA)
    • Ribosome Binding Factor A (RBFA)
    • Tumor Necrosis Factor alpha (TNF)
    • S-Adenosyl-Methionine Synthase (METK)
    • Interleukin 6 (IL6)
    • Interferon gamma (IFNG)
    • Hemoglobin beta (HBB)
    • Triosephosphate Isomerase 1 (TPI1)
    • Thymidylate Kinase (Tmk)
    • Interleukin 4 (IL4)
    • Interleukin 1, beta (IL1B)
    • Interleukin 2 (IL2)
    • Uracil-DNA Glycosylase (UNG)
    • Growth Hormone 1 (GH1)
    • Fibroblast Growth Factor 2 (Basic) (FGF2)
    • Lipoyl synthase lipA
    • Interleukin 10 (IL10)
    • KIT Ligand (KITLG)
    • Malate Dehydrogenase (MDH)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Epidermal Growth Factor (EGF)
    • Leptin (LEP)
    • Interleukin 8 (IL8)
    • Interleukin 3 (IL-3)
    • Myoglobin (MB)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1)
    • Hemoglobin, alpha 1 (HBA1)
    • phosphatidylserine Decarboxylase (PISD)
    • Interleukin 1 alpha (IL1A)
    • Prolactin (PRL)
    • Interleukin 13 (IL13)
    • CD40 Ligand (CD40LG)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • Chemokine (C-X-C Motif) Ligand 12 (CXCL12)
    • Albumin (ALB)
    • Aspartate Carbamoyltransferase (PYRB)
    • Phosphoglucosamine Mutase (GLMM)
    • Interleukin 15 (IL15)
    • Porphobilinogen Deaminase (HEMC)
    • beta-2-Microglobulin (B2M)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • Chemokine (C-C Motif) Ligand 2 (CCL2)
    • Gp120
    • Adiponectin (ADIPOQ)
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
    • Fibroblast Growth Factor 1 (Acidic) (FGF1)
    • Interleukin 33 (IL33)
    • Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1)
  • Application
    • ELISA
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • Crystallization (Crys)
  • Reactivity
    • Mouse
  • Images available
  • Host
    • Insect Cells
  • Binding Specificity
    • AA 1-1172
    • AA 1-1177
    • AA 1-1196
    • AA 1-1233
    • AA 1-906
  • Conjugate
    • Un-conjugated
    • His tag
  • Protein Type
    • Recombinant
  • Format
    • Liquid

NLR Family, Pyrin Domain Containing 1B (NLRP1B) Protein Profile

Protein Summary

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Might be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532). {ECO:0000250|UniProtKB:Q2LKW6, ECO:0000269|PubMed:16429160, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:21170303, ECO:0000269|PubMed:24492532}.

Gene names and symbols associated with NLRP1B

  • NLR family, pyrin domain containing 1B (Nlrp1b) antibody
  • Nalp1b antibody

Protein level used designations for NLRP1B

NACHT-, LRR-, and PYD-containing protein 1 paralog b , NLR family, pyrin domain containing 1B , NLR family, pyrin domain containing 1B, CAST/EiJ specific, allele 3 , NLR family, pyrin domain containing 1B, PWK/PhJ specific, allele 1 , OTTMUSCASG00059402 , OTTMUSPWKG00059388

GENE ID SPECIES
637515 Mus musculus

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