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NLR Family, Pyrin Domain Containing 1B Proteins

(NLR Family, Pyrin Domain Containing 1B (NLRP1B))

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Might be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532). {ECO:0000250|UniProtKB:Q2LKW6, ECO:0000269|PubMed:16429160, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:21170303, ECO:0000269|PubMed:24492532}.

recommended

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1177) protein (Strep Tag) (ABIN3130666)

Crystallography grade NLRP1B Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB

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recommended

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1196) protein (Strep Tag) (ABIN3134880)

Crystallography grade NLRP1B Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB

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recommended

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1172) protein (Strep Tag) (ABIN3134940)

Crystallography grade NLRP1B Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB

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NLR Family, Pyrin Domain Containing 1B Proteins by Grade

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NLR Family, Pyrin Domain Containing 1B Proteins by Origin

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Popular NLR Family, Pyrin Domain Containing 1B Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1177) protein (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3130666

Quantity 1 mg

Datasheet Datasheet

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1196) protein (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134880

Quantity 1 mg

Datasheet Datasheet

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1172) protein (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134940

Quantity 1 mg

Datasheet Datasheet

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-906) protein (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134939

Quantity 1 mg

Datasheet Datasheet

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1233) protein (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3134941

Quantity 1 mg

Datasheet Datasheet

Aliases for NLR Family, Pyrin Domain Containing 1B Proteins

NLR family, pyrin domain containing 1B (Nlrp1b) Proteins
Nalp1b Proteins

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Popular NLR Family, Pyrin Domain Containing 1B Proteins

Aliases for NLR Family, Pyrin Domain Containing 1B Proteins

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