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May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential). Additionally we are shipping NOP2/Sun Domain Family, Member 3 Antibodies (36) and many more products for this protein.
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Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity.
The authors show that the RNA methyltransferase NSUN3 localises to mitochondria and interacts with mt-tRNA(M)(et) to methylate cytosine 34 (C34) at the wobble position.
The NSUN3-knockout cells showed strong reduction in mitochondrial protein (show COX6B2 Proteins) synthesis and reduced oxygen consumption, leading to deficient mitochondrial activity. It reconstituted formation of 5-methylcytidine (m(5)C) at position 34 (m(5)C34) on mt-tRNA(Met) with recombinant NSUN3 in the presence of AdoMet (show MAT1A Proteins), demonstrating that NSUN3-mediated m(5)C34 formation initiates f(5)C34 biogenesis.
May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential).
NOL1/NOP2/Sun domain family 3
, putative methyltransferase NSUN3
, NOL1/NOP2/Sun domain family member 3
, NOL1/NOP2/Sun domain family, member 3
, NOL1/NOP2/Sun domain family member 3-like