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Stress-activated kinase involved in tolerance to glucose starvation. Additionally we are shipping NUAK Family, SNF1-Like Kinase, 2 Antibodies (74) and and many more products for this protein.
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Data (including data from studies in knockout and transgenic mice) suggest that NUAK2/SNARK is involved in both adipose inflammation and energy metabolism in adipocytes; additionally, genome-wide association studies suggest that 2 SNPs in NUAK2/SNARK (rs4682880, rs4682676) are associated with obesity in women.
miR143 inhibited the proliferation, migration and invasion of the glioblastoma cells by degrading NUAK2 in glioblastoma.
Sucrose non-fermenting AMPK (show PRKAA1 Proteins) related kinase/Pentraxin 3 (show PTX3 Proteins) combined role in immunometabolic signaling and DNA damage response is proposed to accelerate cardiovascular complications in systemic lupus erythematosus patients
NUAK2 silencing and inactivation of the PI3K pathway efficiently controlled CDK2 expression, whereas CDK2 inactivation specifically abrogated the growth of NUAK2-amplified and PTEN-deficient melanoma cells.
The AMPK (show PRKAA1 Proteins)-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-beta (show TGFB1 Proteins) signaling.
Activation of AMP-activated protein kinase (show PRKAA2 Proteins) protects the integrity of the blood-brain barrier by suppressing the induction of NADPH oxidase (show NOX1 Proteins)-derived superoxide anions.
Considers possible roles of NUAK2 in tumorigenesis in general and suggest that NUAK2 has pivotal roles in acral melanomagenesis.
MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP (myosin phosphatase Rho-interacting protein) and the inducible kinase NUAK2
This study further supports the importance of NUAK2 in cancer development and tumor progression, while AMPK (show PRKAA1 Proteins) has antioncogenic properties.
Data show that SNARK is activated by muscle contraction and is a unique mediator of contraction-stimulated glucose transport in skeletal muscle.
Data (including data from studies in knockout and transgenic mice) suggest that Nuak2/Snark is involved in both adipose inflammation and energy metabolism in white/brown adipocytes; Nuak2/Snark appears to regulate thermogenesis in brown adipocytes.
These findings reveal a critical role for SNARK in myocyte survival and the maintenance of muscle mass with age.
NUAK1 (show NUAK1 Proteins) and NUAK2 complementarily function in the apical constriction and apico-basal elongation that associate with the dorsolateral hinge point formation in cephalic neural plate during the 5- to 10-somite stages.
Obesity was a risk factor for colorectal tumorigenesis in Snark(+/-) mice model.
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity).
NUAK family SNF1-like kinase 2
, SNF1/AMP activated protein kinase
, SNF1/AMP kinase-related kinase
, omphalocele kinase 2
, SNF1/AMP-activated protein kinase