Natriuretic Peptide A Proteins (NPPA)

Rainbow Trout (Oncorhynchus mykiss) Natriuretic Peptide A (NPPA) interaction partners

1. Expression of atrial natriuretic peptide, C-type natriuretic peptide-1, and the guanylyl cyclase-linked (GC) natriuretic peptide receptor-A (show NPR1 Proteins) and -B-type receptors was determined by PCR from the mRNA of head kidney leucocytes

Pig (Porcine) Natriuretic Peptide A (NPPA) interaction partners

1. Atrial natriuretic peptide and vasopressin (show AVP Proteins)-presence in the ciliary body of eye in the pig (sus domesticus).

2. ANP and BNP gene expression differs considerably between cardiac chambers in the first 72 hours of life in healthy piglets, resembling the transition from fetal to neonate circulation. The cardiac gene expression does not explain plasma concentrations.

3. Up-regulation of ANP and a reduction in a ratio of sarcoplasmic reticulum calcium ATPase 2a and phospholamban (show PLN Proteins) in failing myocardium are observed in a porcine model of tachycardia.

4. Arial natriuretic factor (ANF (show HESX1 Proteins)) and N-terminal proANF may be better suited than brain natriuretic peptide (show BNP Proteins) as markers of cardiac preload during the development and treatment of acute heart failure.

5. Stimulation of prepubertal granulosa cells with FSH (show BRD2 Proteins) resulted in a moderate expression of ANP. When FSH (show BRD2 Proteins) treatment was followed by LH, the pronounced expression of ANP was observed in all cells.

Horse (Equine) Natriuretic Peptide A (NPPA) interaction partners

1. ANP in plasma is increased in horses with heart disease associated with altered left-sided chamber dimensions and/or function.

2. Cardiac ANP was increased in horses with mitral regurgitation (MR) and cardiac troponin levels were low in healthy and MR affected horses.

Human Natriuretic Peptide A (NPPA) interaction partners

1. Upon cardiac stress, Nppa and Nppb (show BNP Proteins) are strongly upregulated in the ventricular myocardium. (Review)

2. Suggest that pro-ANP/corin (show CORIN Proteins)/NPR-C (show NPR3 Proteins) signaling is dominant in the vascular system in preeclampsia.

3. Data indicate the blood pressure-lowering effect of atrial natriuretic peptide (ANP) in the general population.

4. An increase in year-by-year BP variability over the past 6 years is associated with elevated plasma levels of ANP and BNP in the Japanese general population.

5. In summary, there were no significant differences in ANP and BNP levels after percutaneous epicardial left atrial appendage suture ligation using LARIAT device 3 months after procedure.

6. NPPA SNPs were not associated with insulin (show INS Proteins) resistance in older adults.

7. TIMP-4 (show TIMP4 Proteins), NT-proANP, NT-proBNP were strongest associated with PAF (show PAF Proteins) and AHRE (show AHR Proteins). The discriminatory performance of CHADS2-VASc for PAF (show PAF Proteins) was increased by addition of selected biomarkers.

8. ANP inhibits TGF-beta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins) in 16HBE-14o and A549 cells through cGMP/PKG (show PRKG1 Proteins) signaling, by which it targets TGF-beta1 (show TGFB1 Proteins)/Smad3 (show SMAD3 Proteins) via attenuating phosphorylation of Smad3 (show SMAD3 Proteins). These findings suggest the potential of ANP in the treatment on pulmonary diseases with airway remodeling.

9. the ANP T1766C gene polymorphism may be associated with the risk of essential hypertension, and the 1766C allele may be a protective factor against the disease

10. Corin (show CORIN Proteins) and atrial natriuretic peptide A were most abundant in the proximal convoluted tubules and the medullary connecting ducts.

Cow (Bovine) Natriuretic Peptide A (NPPA) interaction partners

1. ANP acts as an anti-permeability factor by inhibiting the signaling functions of vascular permeability factor (show VEGFA Proteins) and by preserving the endothelial cell tight junctions functional morphology

Rabbit Natriuretic Peptide A (NPPA) interaction partners

1. These studies support the therapeutic potential of dual inhibition of NEP (show MME Proteins) and ACE (show ACE Proteins) in the prevention of increased arterial ECP (show ECP Proteins) and atherogenesis which may be linked to the ANP/cGMP system.

2. Diabetes may modify the vascular actions of ANP in isolated rabbit carotid arteries and the mechanisms involved in these actions; ANP induces relaxation of precontracted carotid arteries, which is lower in diabetic than in control rabbits.

3. The study suggests that Beta1-adrenergic receptor activation decreases atrial natriuretic peptide release via cAMP- and Ca(2 (show CA2 Proteins)+)-dependent mechanisms.

Mouse (Murine) Natriuretic Peptide A (NPPA) interaction partners

1. The present study provides a novel insight into the potential underlying mechanisms of telmisartan-induced inhibition of cardiomyocyte hypertrophy, which involves inhibition of NFAT activation, nuclear translocation and the ANP/BNP cascade.

2. we investigated pregnancies of ANP wild type, heterozygous, and knockout mice. Maternal blood pressure did not differ between genotypes, and fetal weight was unaffected. Placental weight was greater in ANP(-/-) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of preeclampsia with fetal growth restriction.

3. Data (including data from studies in knockout mice) suggest expression of ANP/BNP/GC-A (show GUCA1A Proteins) (atrial natriuretic peptide, brain natriuretic peptide (show BNP Proteins), and guanylyl cyclase-A (show NPR1 Proteins)) is important in embryonic neovascularization and organogenesis.

4. Goalpha plays a role in ANF sorting during intracellular vectorial transport and with the presence of a mechanism that preserves the molar relationship between cellular ANF and BNP.

5. ANP prevents cancer metastasis by inhibiting the adhesion of tumor cells to inflamed endothelial cells

6. Expression of NPPA splice variants is differentially regulated in the developing mouse heart.

7. NPPA acts on the NPR1 receptor, is expressed in mouse dorsal root and trigeminal ganglia, and the spinal cord.

8. Natriuretic peptides buffer renin (show REN Proteins)-dependent hypertension.

9. Data indicate that the identified stress-responsive enhancer of Nppa and Nppb (show BNP Proteins), the most common markers of heart failure, is a 650-bp fragment within 50 kb of the Nppa and Nppb (show BNP Proteins) loci.

10. Absence of maternal atrial natriuretic peptide leads to gestational hypertension and adaptive changes fetal cardiac growth and blood pressure regulation.