Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) Proteins (NPR1)

Human Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

1. These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans.

2. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.

3. Data suggest that signaling via ANP/ANPR (atrial natriuretic factor/ANP receptor) in vascular endothelial cells activates PAK4 (p21-activated kinase 4) and CCM2 (cerebral cavernous malformation 2 protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP/ANPR signaling.

4. After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP in HEK-293 cells.

5. Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitivity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss.

6. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation

7. NPRA was detected in E11.5 cardiac progenitor cells.

8. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.

9. High NPR1 expression is associated with esophageal squamous cell carcinomas.

10. Molecular dynamics analysis indicated decreases in the values of Van der Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

11. ACNP stimulated both human natriuretic peptide receptors (NPRs), NPRA and NPRB, as potent as their native ligands in receptor transfected cells.

12. Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain.

13. human ventricular cardiomyocytes express low levels of GC-A and GC-A in cardiomyocytes from failing human hearts is refractory to ANP stimulation.

14. Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury.

15. Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity.

16. Go6976 reduces GTP binding to the catalytic site of GC-A and GC-B and that ATP increases the magnitude of the inhibition.

17. Midregional pro-A-type natriuretic peptide has a comparable accuracy to brain natriuretic peptide BNP for evaluation of cardiocirculatory exercise limitation.

18. NPRA promotes prostate cancer development in part by regulating macrophage migration inhibitory factor

19. review attempts to provide insights and to delineate the current concepts in the field of functional genomics and signaling of GC-A/NPRA in hypertension and cardiovascular disease states at the molecular level

20. we identified and characterized new phosphorylation sites in GC-A and GC-B and provide the first evidence of phosphorylation sites within human guanylyl cyclases.

Zebrafish Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

1. Study identified 2 versions of the npr1 gene (npr1a and npr1b); npr1a was mainly expressed in tectal ventricle, brian, heart and retina, whereas npr1b was broadly present in anterior pronephric duct. npr2 mainly expressed in branchial arches and neural tube during embryonic development; npr3 was expressed in pronephric ducts and corpuscle of stannius in zebrafish embryos at 72 hours after fertilization.

Mouse (Murine) Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

1. A decreased Npr1 copy number enhanced the expression of hypertrophic markers.

2. The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.

3. KLF10 and atrial natriuretic peptide/NPRA in exerting influences on chronic pulmonary disease pathogenesis

4. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (p65), and STAT1.

5. Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.

6. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.

7. Conclude that postnatal cardiac hyperplasia in mice with global GC-A inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation.

8. Data (including data from studies in knockout mice) suggest expression of ANP/BNP/GC-A (atrial natriuretic peptide, brain natriuretic peptide, and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.

9. Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells.

10. Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2.

11. these findings define a novel epigenetic regulatory mechanism that governs Npr1 gene transcription.

12. Npr1 represses the expression of cardiac proinflammatory mediators, hypertrophic markers, and NF-kappaB/AP-1-mediated mechanisms, which seem to be associated in an Npr1 gene-dose-dependent manner

13. ANP is capable of attenuating agonist-induced lung edema in the absence of NPR-A.

14. These results demonstrate that a high-salt diet aggravates cardiac ANG II, aldosterone and pro-inflammatory cytokine levels in Npr1 gene-disrupted 1-copy mice, whereas, in Npr1 gene-duplicated (3-copy and 4-copy) mice, high salt did not render such elevation, suggesting the potential roles of Npr1 against salt loading.

15. ANP-NPRA system exerts an inhibitory effect on MAPKs and down-stream effector molecules, AP-1, and CREB, critical for cell growth and proliferation.

16. Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury.

17. The consequences of the disruption of Npr1 gene on proinflammatory responses of nuclear factor kappa B, inhibitory kappa B kinase, and inhibitory kappa B alpha (NF-kappaB, IKK, IkappaBalpha) in the kidneys of mutant mice, was determined.

18. Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury.

19. Data suggest that a NPPA gradient originating in the oviduct induces sperm chemotaxis by binding to its receptor NPR1 and then activating PKG pathway, and plays a physiological role in fertilization.

20. Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity.

Arabidopsis thaliana Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

1. This work uncovers a strategy in which Pseudomonas syringae AvrPtoB targets Arabidopsis NPR1 and represses NPR1-dependent salicylic acid signaling, thereby subverting plant innate immunity.

2. The findings provide strong support for the direct regulatory roles of TGA3 and WRKY53 in the salicylic acid (SA) and NPR1-dependent activation of a Caulimoviral promoter (CmYLCV).

3. the characterization of a zinc-finger protein-coding gene AtOZF1 that positively influences NPR1-independent salicylic acid signaling, is reported.

4. study not only provides a convenient and efficient transient expression system, but also reveals that NPR1-dependent SA signaling is a major barrier to efficient transient expression

5. We identified a rice mutant in the Kitaake genetic background with a frameshift mutation in crk10; this mutant also displays a compromised immune response highlighting the important role of crk10. We also show that elevated levels of NH1 expression lead to enhanced CRK10 expression and that the rice TGA2.1 protein binds to the CRK10 promoter.

6. Green tissue-specific expression of Arabidopsis thaliana NPR1 is an effective strategy for controlling the sheath blight pathogen (Rhizoctonia solani) in rice. The present work in rice can be extended to other crop plants severely damaged by the pathogen.

7. The results revealed a tight correlation between sequential salicylic acid (SA) and sic acid (ABA) signaling and dynamic changes in NPR1 protein levels and NPR1-dependent transcription in plant immune responses.

8. Crosstalk between nitric oxide and glutathione is integral to the NPR1-dependent defense signaling pathway.

9. The authors show that sumoylation of NPR1 by SUMO3 activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA transcription activators.

10. Altogether, our results indicate that AR156 can induce SAR by the SA-signaling pathways in an NPR1-dependent manner and involves multiple PTI components.

11. NPR1-dependent salicylic acid signaling is not involved in the elevated carbon dioxide-induced heat shock tolerance.

12. NPR1-dependent salicylic acid (SA) signalling is central to the salt and oxidative stress tolerance in Arabidopsis.

13. MPK6-mediated WRKY6 and Trx h5 transcriptional activation co-regulated the expression of the NPR1 gene and the monomerization of NPR1 protein, allowing it to enter the nucleus, thereby promoting salicylic acid-induced leaf senescence.

14. AtNPR1, AtGA2, and AtPR-5, encoding specific components involved in salicylic acid regulation, synthesis, and signaling, are overexpressed in soybean roots, resistance to soybean cyst nematode is enhanced.

15. NPR1 was found to be a positive regulator of jasmonic acid-induced expression of MDHAR3 and TAT3.

16. Fusarium head blight (FHB) severity and mycotoxin accumulation were curtailed in wheat plants treated with SA and in AtNPR1 wheat, which is hyper-responsive to salicylic acid (SA).

17. Data show that the salicylic acid (SA) or infection-induced suppression requires an enhanced desease resistance1 (EDS1) and nonexpressor of pathogenesis-related genes1 (NPR1)-dependent SA pathway in conjunction with Plasmodesmata-located protein5 (PDLP5).

18. Expression of the gene encoding the noexpresser of PR genes 1 (NPR1), a key component of the salicylic acid-signaling pathway, was downregulated by GASA5 overexpression.

19. The npr1 mutation does not significantly affect oxidative stress-induction of the two genes involved in jasmonic acid synthesis.

20. Pseudozyma aphidis may inhibit B. cinerea infection via induced resistance in a manner independent of jasmonic acid, salicylic acid, and Nonexpressor of PR1 (NPR1).