Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) Proteins (NPR1)

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). Additionally we are shipping NPR1 Antibodies (100) and NPR1 Kits (25) and many more products for this protein.

Gene Name	GeneID	UniProt
NPR1	4881	P16066
NPR1	24603	P18910
NPR1	18160	P18293

How to order from antibodies-online

+1 877 302 8632
+1 888 205 9894 (toll-free)
Order online
orders@antibodies-online.com

Top NPR1 Proteins at antibodies-online.com

Showing 8 out of 12 products:

Catalog No.	Origin	Source	Conjugate	Quantity	Supplier	Delivery	Price	Details
ABIN3088820	Insect Cells	Human	His tag	1 mg	Log in to see	60 Days	$9,797.11	Details
ABIN3133181	Insect Cells	Mouse	His tag	1 mg	Log in to see	60 Days	$9,797.11	Details
ABIN5710023	Escherichia coli (E. coli)	Human	His-SUMO Tag	100 μg	Log in to see	11 Days	$411.40	Details
ABIN5713708	Yeast	Human	His tag	100 μg	Log in to see	8 to 11 Days	$484.00	Details
ABIN2727504	HEK-293 Cells	Human	Myc-DYKDDDDK Tag	20 μg	Log in to see	Available	$814.00	Details
ABIN1312893	Wheat germ	Human	GST tag	10 μg	Log in to see	11 to 12 Days	$414.29	Details
ABIN1474120	Yeast	Rat	His tag	1 mg	Log in to see	60 to 71 Days	$3,234.00	Details
ABIN2961249	Baculovirus infected Insect Cells	Human	GST tag	50 μg	Log in to see	10 to 12 Days	$624.55	Details

NPR1 Proteins by Origin and Source

Origin	Expressed in	Conjugate
Human	, , , , ,	, , , ,
Rat (Rattus)
Mouse (Murine)		,

More product categories related to NPR1 Protein

More Proteins for Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) Interaction Partners

Human Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans.
The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.
Data suggest that signaling via ANP (show NPPA Proteins)/ANPR (atrial natriuretic factor/ANP (show NPPA Proteins) receptor (show PPP5C Proteins)) in vascular endothelial cells activates PAK4 (p21-activated kinase 4 (show PAK4 Proteins)) and CCM2 (cerebral cavernous malformation 2 (show CCM2 Proteins) protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP (show NPPA Proteins)/ANPR signaling.
After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP (show NT5C2 Proteins) in HEK (show EPHA3 Proteins)-293 cells.
Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitiv (show INS Proteins)ity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss.
In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation
NPRA was detected in E11.5 cardiac progenitor cells.
Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator.
High NPR1 expression is associated with esophageal squamous cell carcinomas.
Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Proteins) der (show GDF3 Proteins) Waals, electrostatic energy and potential energy of NPRB (show NPR2 Proteins)/Vasonatrin peptide compared to NPRA/Vasonatrin peptide.

Mouse (Murine) Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

A decreased Npr1 copy number enhanced the expression of hypertrophic markers.
The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer.
KLF10 and atrial natriuretic peptide (show NPPA Proteins)/NPRA in exerting influences on chronic pulmonary disease pathogenesis
Treatment of the haplotype Npr1(+/-) mice with histone deacetylase (show HDAC1 Proteins) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Proteins)/2, NF-kappaB (show NFKB1 Proteins) (p65 (show NFkBP65 Proteins)), and STAT1 (show STAT1 Proteins).
Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis.
Conclude that postnatal cardiac hyperplasia in mice with global GC-A (show GUCA1A Proteins) inactivation is provoked by systemic alterations rather than direct regulation of cardiac myocyte proliferation.
Data (including data from studies in knockout mice) suggest expression of ANP (show NPPA Proteins)/BNP/GC-A (show GUCA1A Proteins) (atrial natriuretic peptide (show NPPA Proteins), brain natriuretic peptide (show BNP Proteins), and guanylyl cyclase-A) is important in embryonic neovascularization and organogenesis.
Suggest that the FQQI motif is essential for the internalization and subcellular trafficking of NPRA during the hormone signaling process in intact mesangial cells.
Data suggest activation of skeletal muscle (SM) Npra is important for maintenance of long-term insulin (show INS Proteins) sensitivity; up-regulation of Npra signal transduction in SM (that was reduced by obesity) prevents glucose intolerance and diabetes type 2.

Arabidopsis thaliana Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A) (NPR1) interaction partners

This work uncovers a strategy in which Pseudomonas syringae AvrPtoB targets Arabidopsis NPR1 and represses NPR1-dependent salicylic acid signaling, thereby subverting plant innate immunity.
The findings provide strong support for the direct regulatory roles of TGA3 and WRKY53 in the salicylic acid (SA) and NPR1-dependent activation of a Caulimoviral promoter (CmYLCV).
the characterization of a zinc-finger protein-coding gene AtOZF1 that positively influences NPR1-independent salicylic acid signaling, is reported.
study not only provides a convenient and efficient transient expression system, but also reveals that NPR1-dependent SA signaling is a major barrier to efficient transient expression
We identified a rice mutant in the Kitaake genetic background with a frameshift mutation in crk10; this mutant also displays a compromised immune response highlighting the important role of crk10. We also show that elevated levels of NH1 expression lead to enhanced CRK10 expression and that the rice TGA2.1 protein binds to the CRK10 promoter.
Green tissue-specific expression of Arabidopsis thaliana NPR1 is an effective strategy for controlling the sheath blight pathogen (Rhizoctonia solani) in rice. The present work in rice can be extended to other crop plants severely damaged by the pathogen.
The results revealed a tight correlation between sequential salicylic acid (SA) and sic acid (ABA) signaling and dynamic changes in NPR1 protein levels and NPR1-dependent transcription in plant immune responses.
Crosstalk between nitric oxide and glutathione is integral to the NPR1-dependent defense signaling pathway.
The authors show that sumoylation of NPR1 by SUMO3 (show SUMO3 Proteins) activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA (show TBX1 Proteins) transcription activators.
Altogether, our results indicate that AR156 can induce SAR by the SA-signaling pathways in an NPR1-dependent manner and involves multiple PTI components.

NPR1 Protein Profile

Protein Summary

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994

Gene names and symbols associated with NPR1

natriuretic peptide receptor 1 (NPR1)
natriuretic peptide receptor 1 (Npr1)
natriuretic peptide receptor 1a (npr1a)
regulatory protein (NPR1) (NPR1)

AI893888 protein
ANPa protein
Anpra protein
ARABIDOPSIS NONEXPRESSER OF PR GENES 1 protein
ATNPR1 protein
F15H21.6 protein
F15H21_6 protein
GC-A protein
Gca protein
GUC2A protein
GUCY2A protein
NIM1 protein
NON-INDUCIBLE IMMUNITY 1 protein
NONEXPRESSER OF PR GENES 1 protein
NPR-A protein
Npra protein
Pndr protein
REGULATORY PROTEIN NPR1 protein
SAI1 protein
SALICYLIC ACID INSENSITIVE 1 protein
sGC protein
si:dkey-27c15.1 protein

Protein level used designations for NPR1

ANP-A , ANPR-A , GC-A , NPR-A , atrial natriuretic peptide receptor 1 , atrial natriuretic peptide receptor type A , atrionatriuretic peptide receptor A , guanylate cyclase A , natriuretic peptide A type receptor , natriuretic peptide receptor A , atrial natriuretic peptide A-type receptor , atrial natriuretic peptide receptor A , natriuretic peptide receptor 1 , aatriuretic peptide receptor A , guanylyl cyclase beta 1, soluable , natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) , Nppa receptor , guanylyl cyclase-A

GENE ID	SPECIES
4881	Homo sapiens
24603	Rattus norvegicus
560653	Danio rerio
100343663	Oryctolagus cuniculus
18160	Mus musculus
842733	Arabidopsis thaliana

Selected quality suppliers for NPR1 Proteins (NPR1)

Did you look for something else?

Phone:	+1 877 302 8632
Fax:	+1 888 205 9894 (Toll-free)
E-Mail:	orders@antibodies-online.com