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displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. Additionally we are shipping NEDD8 Antibodies (129) and NEDD8 Proteins (29) and many more products for this protein.
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NEDD8-mediated neddylation promotes stress granule assembly.
NEDD8 seems to inhibit the Src (show SRC ELISA Kits)-mediated phosphorylation of caveolin-1 (show CAV1 ELISA Kits) by modifying the structure of caveolin-1 (show CAV1 ELISA Kits) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.
The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (show TP53 ELISA Kits) status.
Here we report that high expression of neddylation components, NEDD8 and NAE1, are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence
Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.
Furthermore, the authors characterized SENP8/DEN1 (show SENP8 ELISA Kits) as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8 (show SENP8 ELISA Kits)-deficient cells.
MKK7 (show MAP2K7 ELISA Kits) undergoes neddylation in human breast cancer cells
complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (show IL31RA ELISA Kits) regulator Cand1 (show CAND1 ELISA Kits).
In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.
CUL5 (show CUL5 ELISA Kits) neddylation may allosterically tune polyubiquitin (show UBB ELISA Kits) chain length and topology.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (show CUL5 ELISA Kits) is required for its interaction with TRAF6 (show TRAF6 ELISA Kits).
Our findings provide mechanistic evidence of the effects of IAP (show ALPI ELISA Kits) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.
a role of Nedd8 in regulating caspase-1 (show CASP1 ELISA Kits) activation following inflammasome activation
Nedd8 and its associated E2 carrier protein (Ubc12) and E3-SCF (show KITLG ELISA Kits) ligase play a key role in regulating the expression and activity of ENaC (show SCNN1A ELISA Kits) in alveolar pneumocytes.
a new regulatory mechanism of RCAN1 (show RCAN1 ELISA Kits) function
c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.
The NEDD8 pathway appears to play an important role in CD4 (show CD4 ELISA Kits)+ T-cell-mediated inflammatory responses
Nedd8 and AhR (show AHR ELISA Kits) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis
the Cul1 (show CUL1 ELISA Kits)-based SCF (show KITLG ELISA Kits) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (show CCNE1 ELISA Kits) in vivo
Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (show SENP8 ELISA Kits) is crucial for animal viability.
displays differential expression after induction by nerve growth factor
, ubiquitin-like protein Nedd8
, neural precursor cell expressed developmentally down-regulated protein 8
, neural precursor cell expressed, developmentally down-regulated gene 8
, neural precursor cell-expressed developmentally downregulated
, neural precursor cell expressed, developmentally down-regulated 8
, NEDD8 protein
, neural precursor cell expressed, developmentally down-regulated 8 S homeolog