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NCALD encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. Additionally we are shipping Neurocalcin delta Antibodies (31) and Neurocalcin delta Kits (5) and many more products for this protein.
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Neurocalcin delta is a protective spinal muscular atrophy modifier in five asymptomatic SMN1 (show SMN1 Proteins)-deleted individuals carrying only four SMN2 (show SMN1 Proteins) copies.
It is presumed that NCALD is related to diabetic nephropathy by promoting epithelial mesenchymal transform.
Studies show that a fold recognition based model of the catalytic domain of ROS-GC1 (show GUCY2D Proteins) was built, and neurocalcin delta docking simulations were carried out to define the three-dimensional features of the interacting domains of the two molecules.
The author characterizes the biochemical properties of recombinant bovine neurocalcin delta, whose protein sequence is identical to the human ortholog
Neurocalcin-containing DRG neurons include all proprioceptive, and a subset of mechanoreceptive and proprioceptive. Furthermore, NT-3 (show NTF3 Proteins) is involved in the maturation of motor end-plates.
Neurocalcin delta modulates the Ca2+-modulated membrane guanylate cyclase transduction system in the neurons of the retinal inner plexiform layer.
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels\; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein\; additional variants may exist but their biological validity has not been determined.
, Neurocalcin delta