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Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors.
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Human Monoclonal NTSR1 Primary Antibody for - ABIN1384022
Ovigne, Vermot-Desroches, Lecron, Portier, Lupker, Pecceu, Wijdenes: An antagonistic monoclonal antibody (B-N6) specific for the human neurotensin receptor-1. in Neuropeptides 1999
Cow (Bovine) Polyclonal NTSR1 Primary Antibody for WB - ABIN2777123
Carraway, Hassan: Neurotensin receptor binding and neurotensin-induced growth signaling in prostate cancer PC3 cells are sensitive to metabolic stress. in Regulatory peptides 2007
Show all 2 Pubmed References
Human Polyclonal NTSR1 Primary Antibody for IHC (p) - ABIN271365
Gui, Liu, Yan, Gao: Neurotensin receptor 1 overexpression in inflammatory bowel diseases and colitis-associated neoplasia. in World journal of gastroenterology 2013
Data demonstrate that the NTR1 can modulate the methamphetamine-induced striatal neuronal apoptosis independent of body temperature regulation. Possible mechanisms of NTR1 modulating methamphetamine-induced apoptosis include the regulation of dopamine and glutamate (show GRIN1 Antibodies) neurotransmission in the striatum.
The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported.
sleep traits and a relationship between Ntsr1 and anxiety and despair behaviors in knockout mice
Data show that NTS1 (show NTS Antibodies)(-/-) mouse is an animal model of schizophrenia, particularly for the dysfunction of the prefrontal cortex.
Ntsr1 knockout mice showed a higher freezing rate than wild type mice at both first and second exposures under the condition where a relatively weak unconditioned stimulus (footshock)
Ntsr1 receptor subtype is necessary for normal dopaminergic function.
These findings support the role for Ntsr1 in the mediation of the metabolic effect of xenin (show COPA Antibodies) as well as neurotensin (show NTS Antibodies).
Neurotensin (show NTS Antibodies) type 1 receptor does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion.
constant activation of NT1 receptor generates an oncogenic regulation
NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 (show COX2 Antibodies) dependent pathway.
Our findings identify promoter methylation as an important process regulating the differential expression or silencing of NTSR1/2 in Colorectal cancer (CRC (show CALR Antibodies)) cells. Moreover, inhibition of NTSR1 repressed tumorigenic effects in CRC (show CALR Antibodies) cells, suggesting that NTSR1 may be used as a therapeutic target for CRC (show CALR Antibodies).
inducing exogenous neurotensin stimulation and enhancing NTR1 expression promoted tumor invasion rather than proliferation by accelerating epithelial-to-mesenchymal transition in hepatocellular carcinoma cells.
High NTR1 expression is associated with pancreatic ductal adenocarcinoma.
Data suggest that small molecule ligand binding to neurotensin receptor 1 (NTSR1) could facilitate the structure-based design of non-peptide ligands for the evaluation of the pharmacological potential of NTSR1 in neurological disorders and cancer.
The results reveal a positive feedback loop between NTS (show NTS Antibodies)/NTSR1 and Wnt (show WNT2 Antibodies)/beta-Catenin (show CTNNB1 Antibodies) signaling in glioblastoma cells that might be important for tumor development and provide potential therapeutic targets for glioblastoma.
NTSR1 overexpression is a poor prognostic factor in endometrial cancer, highlighting the contribution of NTS (show NTS Antibodies) in endometrial cancer progression
Heterodimerization of the kappa opioid receptor (show OPRK1 Antibodies) and neurotensin receptor 1 contributes to a novel beta-arrestin-2 (show ARRB2 Antibodies)-signaling pathway.
Silencing of miR-133alpha or overexpression of aftiphilin attenuated NTR1 trafficking to plasma membrane in human colonocytes.
Neurotensin (show NTS Antibodies) receptor-targeted oncolytic adenovirus co-expressing decorin (show DCN Antibodies) and Wnt (show WNT2 Antibodies) antagonist useful for systemic treatment of NTR-overexpressing pancreatic cancer.
high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 (show NTSR2 Antibodies) in NET cells
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion.
neurotensin receptor type 1
, neurotensin receptor 1 (high affinity)
, neurotensin receptor type 1-like
, high-affinity levocabastine-insensitive neurotensin receptor