Neurotensin Receptor 2 Proteins (NTSR2)

Human Neurotensin Receptor 2 (NTSR2) interaction partners

1. High NTSR2 expression is associated with B-cell chronic lymphocytic leukemia.

2. We showed that expression levels for NTS and NTSR1 varied, that NTSR2 expression was not detectable and that NTSR3 was consistently expressed in all CRC cell lines examined.

3. high expression of NTSR1 is found in clinical NETs and promoter methylation is an important mechanism controlling the differential expression of NTSR1 and silencing of NTSR2 in NET cells

4. NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was not expressed in B cell leukemia patient's B-cells, as compared with healthy B cells.

5. this study proposes a novel function of NTR2 in the regulation of NTR1 activity.

6. NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+)

7. Recycling ability depends on a single tyrosine residue

8. ghrelin receptor, neurotensin receptor 2 and GPR39 display an unusually high degree of constitutive activity, determined by an aromatic cluster on the inner face of the extracellular ends of TMs VI and VII

9. NTR1 and NTR2 mRNA were not detected in either pituitary adenomas or normal tissue.

Mouse (Murine) Neurotensin Receptor 2 (NTSR2) interaction partners

1. Study shows that neurotensin receptor 2 expression remains constant throughout lifespan, and is predominantly expressed within glia.

2. Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala identify and validate Ntsr2-expressing neurons as a putative 'Fear-Off' population.

3. endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors.

4. findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption

5. These data support the regulation of baseline prepulse inhibition, acoustic startle response and locomotor activity by endogenous neurotensin acting at the NT2 receptor.

6. Ntsr2 receptor subtype is necessary for normal dopaminergic function.

7. NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.

8. transcriptional regulation; maps to chromosome 12

9. Recycling ability depends on a single tyrosine residue

10. increase in jump latency induced by stimulation of NTS2 receptors is mediated by the release of an endogenous opioid receptor ligand

11. These results suggest that Ntsr2 in astrocytes and neurons may have unique function like a modulation of fear memory in the mouse brain.