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NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. Additionally we are shipping NCF2 Antibodies (49) and many more products for this protein.
Showing 9 out of 12 products:
analysis of NCF2, BCKDHB (show BCKDHB Proteins) and BCKDHA (show BCKDHA Proteins) in pig
We analyzed the clinical and laboratory findings of CGD (show CYBB Proteins) with mutations in the NCF2 gene from amongst our cohort of CGD (show CYBB Proteins) patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.
All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.
Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (show NCF4 Proteins) and p67phox at the phagosomal membrane.
TLR4 (show TLR4 Proteins)- and TLR2-induced IRAK (show IRAK1 Proteins)-ERK (show EPHB2 Proteins) pathway cross-talks with p67phox-Nox-2 (show CYBB Proteins) for reactive oxygen species generation, thus regulating IL-1beta (show IL1B Proteins) transcription and processing in monocytic cells.
Skeletal muscle protein expression of the NADPH oxidase (show NOX1 Proteins) subunits p22(phox (show CYBA Proteins)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (show CYBA Proteins)) and p67(phox) expression was attenuated by exercise training in obese subjects.
A novel homozygous mutation in NCF2.
results reveal an essential role for the Cys (show DNAJC5 Proteins)-Gly-Cys (show DNAJC5 Proteins) triad in Nox2 (show CYBB Proteins) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (show DNAJC5 Proteins)-Gly-Cys (show DNAJC5 Proteins). The 2 regions interact with distinct partner sites in p67(phox).
This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (show NCF4 Proteins)/VAV1 (show VAV1 Proteins)/RAC1 NADPH oxidase (show NOX1 Proteins) complex.
Data indicate that arachidonic acid induces the direct interaction of Rac (show AKT1 Proteins)-GTP (show AK3 Proteins)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (show NOX1 Proteins) Nox2 (show CYBB Proteins).
Four novel mutations in the NCF1 (show NCF1 Proteins), NCF2, and CYBB (show CYBB Proteins) genees have been identified in chronic granulomatous disease patients in Morocco.
Just as patients with chronic granulomatous disease who lack NADPH oxidase (show NOX1 Proteins) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.
p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (show PLA2G2A Proteins) activity, an interaction that could function to terminate the PLA2 (show PLA2G2A Proteins)-mediated NOX2 (show CYBB Proteins) activation signal.
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (show FDXR Proteins) oxidasesubunit (67kDa (show RPSA Proteins)) and the resultant metabolic oxidative stress.
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (show CYBB Proteins)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (show SLC2A4 Proteins)-/-) mice.
This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.
This study demonstrates the involvement of ROS (show ROS1 Proteins) from NADPH oxidase (show NOX1 Proteins) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (show PKCd Proteins)- and ERK (show EPHB2 Proteins)-dependent pathways.
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
, neutrophil cytosolic factor 2
, neutrophil cytosol factor 2
, predicted neutrophil cytosolic factor 2
, NADPH oxidase cytosolic protein p67phox
, NADPH oxidase cytosolic protein
, 67 kDa neutrophil oxidase factor
, NADPH oxidase activator 2
, chronic granulomatous disease, autosomal 2
, neutrophil NADPH oxidase factor 2
, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
, NADPH oxidase subunit (67 kD)
, NADPH oxidase subunit (67kDa)