Nicotinamide N-Methyltransferase Proteins (NNMT)

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. Additionally we are shipping NNMT Antibodies (118) and NNMT Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NNMT 4837 P40261
NNMT 18113 O55239
Rat NNMT NNMT 300691  
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Top NNMT Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag 100 μg 13 to 16 Days
$492.31
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
$698.00
Details
Escherichia coli (E. coli) Human His tag 100 μg 2 to 3 Days
$495.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Mouse His tag 100 μg 13 to 16 Days
$953.85
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Mouse His tag 100 μg 15 to 18 Days
$672.00
Details
Escherichia coli (E. coli) Human His tag   1 mg 2 to 3 Days
$3,655.38
Details

NNMT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

More Proteins for Nicotinamide N-Methyltransferase (NNMT) Interaction Partners

Human Nicotinamide N-Methyltransferase (NNMT) interaction partners

  1. Polymorphisms in rs694539-NNMT gene (mutant AA-genotype) could be a genetic risk factor for developing NAFLD and NASH (indicating susceptibility for progression and complications).

  2. This sudu used a combination of site-directed mutagenesis, kinetics, and circular dichoism experiments to demonstrate that citrullination of R132 leads to a structural perturbation that ultimately promotes NNMT inactivation.

  3. Results obtained showed significantly (P<0.0001) higher NNMT expression in melanoma compared with that detected in nevi. In addition, a significant (P<0.05) inverse relationship was found between enzyme levels and Breslow thickness, Clark level, the presence/number of mitoses, and ulceration.

  4. TGF-beta1 is significantly overexpressed in tumor tissue samples of clear cell Renal cell carcinoma patients. TGF-beta1 up-regulation could be responsible for the high levels of NNMT observed in clear cell Renal cell carcinoma tissues.

  5. Our data indicate that NNMT is a promising biomarker that could be used to support the early and noninvasive diagnosis of Bladder cancer

  6. Here we explored the association between NNMT gene polymorphisms and obesity. The subjects were recruited from male Chinese Han college student... the variation of the tagSNP, rs10891644, is significantly associated with obesity and the GT carriers are the susceptible population

  7. our results suggest that the ZEB1/NNMT signaling axis induces phenotypic and metabolic plasticity, as well as mesenchymal gene expression in ovarian cancer cells upon chronic glucose deprivation

  8. We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK).

  9. High expression level of NNMT is associated with pancreatic cancer.

  10. This finding, for the first time, suggests the involvement of the NNMT gene rs694539 variant in the etiology of epilepsy.

  11. this study provides the first demonstration that NNMT plays a role in the resistance to 5-fluorouracil in colorectal cancer cells

  12. We suggest that lymph node metastatic adenoid cystic carcinoma (AdCC) cells acquire cancer stem cell features involving the up-regulation of NNMT and the loss of gap junction protein alpha-1, leading to epithelial-mesenchymal transition and consequent AdCC metastasis.

  13. Progression of pulmonary hypertension is associated with the activation of the NNMT-1-methylnicotinamide pathway.

  14. no SNP in NNMT is significantly associated with performance in 50-m run but rs2256292 is significantly associated with performance in 1000-m run in male Chinese college students

  15. These findings indicate that the repression of NNMT may underlie nickel-induced H3K9 dimethylation by altering the cellular SAM/SAH ratio.

  16. NNMT expression is significantly upregulated in human masticatory mucosa during wound healing

  17. The results show that a SNP (rs1941404) in NNMT is significantly associated with hyperlipidemia, and the influence of rs1941404 variation on the resting energy expenditure may be the possible mechanism for rs1941404 variation to induce hyperlipidemia.

  18. NNMT gene rs694539 variant is a genetic risk factor for migraine in women.

  19. There were no associations between MTHFR C677T, NNMT rs694539 AG/AA polymorphisms and conotruncal heart disease.

  20. Data show that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in embryonic stem cells (hESCs).

Mouse (Murine) Nicotinamide N-Methyltransferase (NNMT) interaction partners

  1. by co-opting the enzymes of the methionine cycle, Nnmt aids the recycling of homocysteine to S-adenosylmethionine for another round of methylation.

  2. Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide have been presented.

  3. NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes

  4. Brain NNMT expression was not altered in hyperhomocysteinemia.

  5. Adipose tissue is a source of nicotinamide N-methyltransferase and homocysteine.

  6. the progression of vascular inflammation and atherosclerosis was associated with the upregulation of hepatic nicotinamide N-methyltransferase activity and subsequent increase in endogenous MNA plasma levels

NNMT Protein Profile

Protein Summary

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.

Gene names and symbols associated with NNMT

  • nicotinamide N-methyltransferase S homeolog (nnmt.S)
  • nicotinamide N-methyltransferase (CNG02680)
  • nicotinamide N-methyltransferase (AFUA_1G17750)
  • nicotinamide N-methyltransferase (AOR_1_1132194)
  • nicotinamide N-methyltransferase (AOR_1_1124014)
  • nicotinamide N-methyltransferase (CC1G_02598)
  • nicotinamide n-methyltransferase (VDBG_08111)
  • nicotinamide N-methyltransferase (TERG_00572)
  • nicotinamide N-methyltransferase (Tsp_04293)
  • Nicotinamide N-methyltransferase (nnmt)
  • nicotinamide N-methyltransferase (NNMT)
  • nicotinamide N-methyltransferase (Nnmt)
  • Afu1g17750 protein
  • AO090026000620 protein
  • MGC64498 protein
  • nnmt protein

Protein level used designations for NNMT

nicotinamide N-methyltransferase , nicotinamide n-methyltransferase , Nicotinamide N-methyltransferase

GENE ID SPECIES
379432 Xenopus laevis
3258655 Cryptococcus neoformans var. neoformans JEC21
3510174 Aspergillus fumigatus Af293
5988105 Aspergillus oryzae RIB40
5994073 Aspergillus oryzae RIB40
6016766 Coprinopsis cinerea okayama7130
9529830 Verticillium alfalfae VaMs.102
10374048 Trichophyton rubrum CBS 118892
10905204 Trichinella spiralis
100286563 Salmo salar
4837 Homo sapiens
489396 Canis lupus familiaris
100144485 Sus scrofa
18113 Mus musculus
300691 Rattus norvegicus
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