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N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. Additionally we are shipping NNMT Antibodies (128) and NNMT Kits (19) and many more products for this protein.
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Our data indicate that NNMT is a promising biomarker that could be used to support the early and noninvasive diagnosis of Bladder cancer
Here we explored the association between NNMT gene polymorphisms and obesity. The subjects were recruited from male Chinese Han college student... the variation of the tagSNP, rs10891644, is significantly associated with obesity and the GT carriers are the susceptible population
our results suggest that the ZEB1/NNMT signaling axis induces phenotypic and metabolic plasticity, as well as mesenchymal gene expression in ovarian cancer cells upon chronic glucose deprivation
We demonstrate that NNMT outcompetes leucine carboxyl methyl transferase 1 (LCMT1) for methyl transfer from principal methyl donor SAM in biological systems. Inhibiting NNMT increased the availability of methyl groups for LCMT1 to methylate PP2A, resulting in the inhibition of oncogenic serine/threonine kinases (STK).
High expression level of NNMT is associated with pancreatic cancer.
This finding, for the first time, suggests the involvement of the NNMT gene rs694539 variant in the etiology of epilepsy.
this study provides the first demonstration that NNMT plays a role in the resistance to 5-fluorouracil in colorectal cancer cells
We suggest that lymph node metastatic adenoid cystic carcinoma (AdCC) cells acquire cancer stem cell features involving the up-regulation of NNMT and the loss of gap junction protein alpha-1 (show GJA1 Proteins), leading to epithelial-mesenchymal transition and consequent AdCC metastasis.
Progression of pulmonary hypertension is associated with the activation of the NNMT-1-methylnicotinamide pathway.
no SNP in NNMT is significantly associated with performance in 50-m run but rs2256292 is significantly associated with performance in 1000-m run in male Chinese college students
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide have been presented.
NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 (show SIRT1 Proteins) signalling, and is a unique and attractive target for treating obesity and type 2 diabetes
Brain NNMT expression was not altered in hyperhomocysteinemia.
Adipose tissue is a source of nicotinamide N-methyltransferase and homocysteine.
the progression of vascular inflammation and atherosclerosis was associated with the upregulation of hepatic nicotinamide N-methyltransferase activity and subsequent increase in endogenous MNA plasma levels
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.
, nicotinamide n-methyltransferase
, Nicotinamide N-methyltransferase